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Preparation method and application of combined traditional Chinese medicine extract with anti-inflammatory and pain-relieving effect

An anti-inflammatory and analgesic, extract technology, applied in the field of medicine, can solve the problems of anti-inflammatory and analgesic, anti-inflammatory and analgesic, no two-phase system, etc., and achieve the effect of easy to master technology, low production cost and simple process

Inactive Publication Date: 2018-02-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the two-phase system as the extraction solvent for the preparation of traditional Chinese medicine combination extracts, and no two-phase system composed of n-propanol-potassium sodium tartrate-water is used as the extraction solvent to extract the raw medicinal materials in parts by weight. , 3 parts of honeysuckle, 3 parts of smilax, 2 parts of forsythia, 2 parts of leaking reed, 2 parts of angelica, 2 parts of Gentiana, 2 parts of Burnet, 2 parts of Fangfeng, 2 parts of turmeric, and 1 part of licorice to obtain the Chinese medicine combination extract The preparation method, there is no application of the traditional Chinese medicine combination extract with anti-inflammatory and analgesic effects obtained by this preparation method in the preparation of anti-inflammatory and analgesic and treatment of hemorrhoids products

Method used

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  • Preparation method and application of combined traditional Chinese medicine extract with anti-inflammatory and pain-relieving effect
  • Preparation method and application of combined traditional Chinese medicine extract with anti-inflammatory and pain-relieving effect
  • Preparation method and application of combined traditional Chinese medicine extract with anti-inflammatory and pain-relieving effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Take 300g of cooked rhubarb, 300g of honeysuckle, 300g of smilax, 200g of forsythia, 200g of leaking reed, 200g of angelica, 200g of Gentiana, 200g of Burnet, 200g of Fangfeng, 200g of turmeric, 100g of licorice, crush them through a 50-mesh sieve, and add the raw material powder The two-phase system extraction solvent 24Kg that n-propanol-potassium sodium tartrate-water forms, the massfraction of n-propanol in the two-phase system extraction solvent is 25.75%, the massfraction of potassium sodium tartrate is 11.00%, and the massfraction of water is 63.25%, microwave-assisted extraction for 30 minutes, the extraction temperature is 80°C, the microwave power is 400W, stand for phase separation, the phase separation temperature is 30°C, the phase separation time is 4 hours, the upper phase is separated, and an equal weight of normal Propanol, left standing at 4°C for 48 hours, filtered, and the filtrate was concentrated under reduced pressure and dried to obtain 182.4 g of...

Embodiment 2

[0122] Take 300g of cooked rhubarb, 300g of honeysuckle, 300g of smilax, 200g of forsythia, 200g of leaking reed, 200g of angelica, 200g of Gentiana, 200g of Burnet, 200g of Fangfeng, 200g of turmeric, 100g of licorice, crush them through a 50-mesh sieve, and add the raw material powder The two-phase system extraction solvent 24Kg that n-propanol-potassium sodium tartrate-water forms, the massfraction of n-propanol in the two-phase system extraction solvent is 35.26%, the massfraction of potassium sodium tartrate is 7.97%, and the massfraction of water is 56.77%, microwave-assisted extraction for 30 minutes, the extraction temperature is 80°C, the microwave power is 600W, stand for phase separation, the phase separation temperature is 30°C, the phase separation time is 2 hours, the upper phase is separated, and an equal weight of normal Propanol, left standing at 4°C for 48 hours, filtered, and the filtrate was concentrated under reduced pressure and dried to obtain 204.0 g of ...

Embodiment 3

[0124] Take 300g of cooked rhubarb, 300g of honeysuckle, 300g of smilax, 200g of forsythia, 200g of leaking reed, 200g of angelica, 200g of Gentiana, 200g of Burnet, 200g of Fangfeng, 200g of turmeric, 100g of licorice, crush them through a 50-mesh sieve, and add the raw material powder The two-phase system extraction solvent 24Kg that n-propanol-potassium sodium tartrate-water forms, the massfraction of n-propanol in the two-phase system extraction solvent is 44.88%, the massfraction of potassium sodium tartrate is 4.88%, the massfraction of water is 50.24%, microwave-assisted extraction for 30 minutes, the extraction temperature is 80°C, the microwave power is 800W, stand for phase separation, the phase separation temperature is 30°C, the phase separation time is 4 hours, the upper phase is separated, and an equal weight of normal Propanol, left standing at 4°C for 48 hours, filtered, and the filtrate was concentrated under reduced pressure and dried to obtain 225.6 g of the ...

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Abstract

The invention provides a preparation method and application of combined traditional Chinese medicine extract with an anti-inflammatory and pain-relieving effect. The combined traditional Chinese medicine extract is prepared from, by weight, 3 parts of cooked rhubarb, 3 parts of lonicera japonica, 3 parts of glabrous greenbrier rhizome, 2 parts of forsythia suspensa, 2 parts of uniflower swisscentaury root, 2 parts of angelica sinensis, 2 parts of gentiana macrophylla, 2 parts of garden burnet root, 2 parts of Chinese parsnip root, 2 parts of curcuma aromatica and 1 part of glycyrrhiza uralensis. The preparation method comprises the steps that the medicinal materials are ground, an aqueous two phase system composed of n-propyl-seignette salt-water is used as extracting solvent for microwaveassisted extraction, phase splitting is conducted, the upper phase is desalted, and the solvent is recycled to obtain the extract; the preparation method has the advantages that extraction and leaching are integrated, amplification is easy, continuous operation is achieved, technologies are easy to integrate and the method is green and environmentally friendly. The invention further discloses application of the combined traditional Chinese medicine extract obtained by the preparation method in preparation of anti-inflammatory and pain-relieving products and hemorrhoid treatment products.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a preparation method of a traditional Chinese medicine composition extract with anti-inflammatory and analgesic effects, and also relates to the application of the anti-inflammatory and analgesic effect of the traditional Chinese medicine composition extract obtained by the preparation method in the preparation of anti-inflammatory, analgesic and hemorrhoid treatment products . Background technique [0002] The aqueous two-phase system is a two-phase system that is impermeable to each other after two phase-forming substances are fully dissolved in water, under the influence of intermolecular repulsion and steric hindrance, and balanced for a period of time. The current common aqueous two-phase system consists of polymer-polymer-water, polymer-salt-water, ionic liquid-salt-water, small molecule hydrophilic organic solvent-salt-water. The traditional Chinese medicine composition is extracted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P29/00A61P9/14
CPCA61K36/232A61K36/238A61K36/28A61K36/355A61K36/484A61K36/51A61K36/634A61K36/708A61K36/739A61K36/896A61K36/90A61K36/9066A61K2236/333A61K2236/53A61K2300/00
Inventor 王威师海波刘坤韩立春刘小红高华孙世伟刘洋
Owner QINGDAO UNIV
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