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A kind of intratumoral injection for treating rhabdomyosarcoma

A technique for rhabdomyosarcoma and injection, applied in the field of intratumoral injection

Active Publication Date: 2018-09-04
张欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As of now, there is no report on the antitumor activity of 2,5-dimethoxy-4-iodophenylpropan-2-amine hydrochloride in the literature

Method used

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  • A kind of intratumoral injection for treating rhabdomyosarcoma
  • A kind of intratumoral injection for treating rhabdomyosarcoma
  • A kind of intratumoral injection for treating rhabdomyosarcoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Intratumoral injection for the treatment of rhabdomyosarcoma and its preparation

[0026]

[0027] Preparation:

[0028] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the dosage of mannitol is 3 times of the weight of Danshensu, the consumption of sodium acetate is 0.06 times of the weight of Danshensu, and the dosage of 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 9.6mg / ml.

Embodiment 2

[0029] Example 2 Intratumoral injection for treating rhabdomyosarcoma and its preparation

[0030]

[0031] Preparation:

[0032] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the dosage of mannitol is 3 times of the weight of Danshensu, the consumption of sodium acetate is 0.06 times of the weight of Danshensu, and the dosage of 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 9.8mg / ml.

Embodiment 3

[0033] Example 3 Intratumoral injection for treating rhabdomyosarcoma and its preparation

[0034]

[0035] Preparation:

[0036] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the consumption of mannitol is 4 times of the weight of Danshensu, the consumption of sodium acetate is 0.05 times of the weight of Danshensu, 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 10.0mg / ml.

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Abstract

The invention relates to the field of medicines, and particularly relates to intratumoral injection for treating rhabdomyosarcoma. The intratumoral injection is prepared from the following componentsin parts by weight: 11-21 parts of tanshinol, 2-5 parts of 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride, and a pharmaceutically acceptable medicinal auxiliary material which is preferably prepared from mannitol, sodium acetate and injection water, wherein the tanshinol has a certain effect for resisting rhabdomyosarcoma; and no anti-tumor effect for a rhabdomyosarcoma cell lineand animal model is found in 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride, but cell and animal experiments indicate that 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride has a remarkable synergistic effect for the rhabdomyosarcoma resistance of tanshinol. The intratumoral injection has excellent safety in intratumoral injection.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an intratumoral injection for treating rhabdomyosarcoma. Background technique [0002] Rhabdomyosarcoma is a malignant tumor originating from striated muscle cells or mesenchymal cells that differentiate into rhabdomyosarcoma. The disease often occurs in children, accounting for about 50% of soft tissue sarcoma in children under the age of 15, accounting for 4% to 8% of all malignant tumors in children (Li Dongliang, Liu Chunxia, ​​Zou Hong, Li Feng. Molecular biology research progress of rhabdomyosarcoma. Clinical Journal of Experimental Pathology. 2011,27(2):181-185.). The incidence rate of adults is low, and the incidence rate of men is higher. It is a kind of soft tissue sarcoma with a higher degree of malignancy, and regional lymph node metastasis and hematologic metastasis are prone to occur. [0003] At present, there are relatively few studies on rhabdomyosarcoma, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/192A61K31/137A61P35/00
CPCA61K9/0019A61K9/08A61K31/137A61K31/192A61K47/12A61K47/26A61K2300/00
Inventor 张欣姚静王飞
Owner 张欣
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