Pharmaceutical composition containing sequoyitol as well as preparation method and application thereof

A composition and a technique of seclitaxel, which are applied in the field of pharmaceutical compositions containing seclitaxel and the preparation thereof, can solve the problems of no disclosure of the application of seclitaxel compositions, no hepatoprotective drugs, and no hepatoprotective drugs. , to achieve the effect of low price, safe medication and clear ingredients

Inactive Publication Date: 2018-03-06
朗致集团江西医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the hepatoprotective drug with single component of pinitol and paclitaxel as the active ingredient has not been reported in China, and there is no report of the hepatoprotective drug with the composition formed by mixing pinitol and paclitaxel as the active ingredient; The application of the composition formed by total flavonol glycosides, ginkgolides, pinitol, and paclitaxel for liver protection has been disclosed, and there is no liver protection product in the form of its composition as the raw material drug on the market. drug

Method used

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  • Pharmaceutical composition containing sequoyitol as well as preparation method and application thereof
  • Pharmaceutical composition containing sequoyitol as well as preparation method and application thereof
  • Pharmaceutical composition containing sequoyitol as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The pharmaceutical composition containing paclitaxel in this embodiment includes the following components: paclitaxel 3mg, pinitol 20mg;

[0046] The above-mentioned selected parts by weight of paclitaxel, pinitol, water, and auxiliary materials are mixed to form a sterile solution with a pH value of 7.0, wherein the content of the paclitaxel in the sterile solution is 0.3 mg / mL, The content of the pinitol in the sterile solution is 2mg / mL.

Embodiment 2

[0048]The pharmaceutical composition containing paclitaxel in this embodiment includes the following components: paclitaxel 4mg, pinitol 15mg, ginkgolide A 2mg, ginkgolide B 1mg, ginkgolide C 0.4mg, narcissin 0.9mg, Protol-3-O-[6-O-(α-L-rhamnosyl)]-β-D-glucoside 0.3mg;

[0049] The above-mentioned seclitaxel, pinitol, ginkgolide A, ginkgolide B, ginkgolide C, narciscin and kaempferol-3-O-[6-O-(α-L- Rhamnosyl)]-β-D-glucoside is mixed with water and auxiliary materials to make a sterile solution with a pH value of 5.0, wherein the content of the paclitaxel in the sterile solution is 0.4mg / mL, The content of the pinitol in the sterile solution is 1.5mg / mL.

Embodiment 3

[0051] The pharmaceutical composition containing paclitaxel in this embodiment includes the following components: paclitaxel 4.5 mg, pinitol 20 mg, ginkgolide A 1.8 mg, ginkgolide B 0.9 mg, ginkgolide C 0.4 mg, narciscin 0.1 mg, kaempferol-3-O-[6-O-(α-L-rhamnosyl)]-β-D-glucoside 0.9mg;

[0052] The above-mentioned seclitaxel, pinitol, ginkgolide A, ginkgolide B, ginkgolide C, narciscin and kaempferol-3-O-[6-O-(α-L- Rhamnosyl)]-β-D-glucoside is mixed with water and auxiliary materials to make a sterile solution with a pH value of 5.0, wherein the content of the paclitaxel in the sterile solution is 0.45mg / mL, The content of the pinitol in the sterile solution is 2mg / mL.

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PUM

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Abstract

The invention provides a pharmaceutical composition containing sequoyitol as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following components according to the specific weight part: pinitol and the sequoyitol; all crude drugs have mutual matching and common effects under the specific ratio, so that the composition provided by the invention has a remarkable liver-protecting effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition containing paclitaxel, a preparation method and application thereof. Background technique [0002] The liver is the largest digestive gland in the human body. It not only secretes bile to participate in digestion, but also has important functions such as nutrient metabolism, glycogen storage, detoxification, and phagocytosis defense. Bad eating habits are an important cause of liver damage. Bad eating habits can cause metabolic and physiological disorders in the body, cause physical and psychological balance, and then lead to liver dysfunction and liver damage. [0003] my country is one of the countries with a high incidence of liver disease. At present, the western medicines used to treat liver diseases mainly include antiviral drugs, immunomodulatory drugs, and liver-protecting and enzyme-lowering drugs. The above-mentioned drugs all hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/075A61K31/365A61P1/16
CPCA61K31/075A61K31/365A61K31/7048A61K36/16A61K2300/00
Inventor 王锋杨满辉
Owner 朗致集团江西医药有限公司
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