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Method for six active components in drug sample

A technology of active ingredients and samples, which is applied in the field of medicine, can solve the problems of public reports on the content of active ingredients of cold medicines, etc., and achieve the effects of wide range of detection applications, efficient detection, and wide range of detection applications

Active Publication Date: 2018-03-09
HUMANWELL PURACAP PHARM WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no public report on the method of simultaneously determining the content of multiple drug active components in cold medicines

Method used

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  • Method for six active components in drug sample
  • Method for six active components in drug sample
  • Method for six active components in drug sample

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] In this embodiment, according to the configuration method and test conditions that are basically the same as the general method, 20 microliters of the reference solution is taken and injected into the high performance liquid chromatograph for testing. The difference is that the mobile phase ratio used in this embodiment performs gradient elution according to the following conditions:

[0047]

[0048]

[0049] The chromatogram detected in this example is as figure 1 Shown. by figure 1 The relevant information of each chromatographic peak is available, as follows:

[0050] Active ingredient name

[0051] among them, Figure 1~4 Where P stands for phenylephrine hydrochloride, A stands for paracetamol, Doxy stands for doxylamine succinate, Cl stands for chlorpheniramine maleate, Gua stands for glycerol guaiacol ether, and Dextro stands for hydrobromic acid Dextromethorphan.

Embodiment 2

[0053] In this embodiment, according to the test conditions that are basically the same as those in embodiment 1, 20 microliters of sample solution is taken and injected into the high performance liquid chromatograph for detection. The difference is that the drug sample used in this embodiment is specifically the Daytime Severe Cold and Flu soft capsule, which includes the acetaminophen component and the guaiacol glycerol ether component.

[0054] The chromatogram of the sample solution of this embodiment is as figure 2 Shown.

[0055] by figure 2 It can be seen that the relevant information of the chromatographic peaks corresponding to the two components is shown in the following table:

[0056] Active ingredient name

Embodiment 3

[0058] In this embodiment, according to the test conditions that are basically the same as those in embodiment 1, 20 microliters of the sample solution is taken and injected into the high performance liquid chromatograph for detection. The difference is that the sample used in this embodiment is specifically the Nighttime Coldand Flu soft capsule, which includes a component of doxylamine succinate and a component of dextromethorphan hydrobromide.

[0059] The chromatogram of the sample solution of this embodiment is as image 3 Shown.

[0060] by image 3 It can be seen that the relevant information of the chromatographic peaks corresponding to the two components is shown in the following table:

[0061] Active ingredient name

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Abstract

The invention provides a method for six active components in a drug sample. In the method, the six active components comprise paracetamol, phenylephrine hydrochloride, doxylamine succinate, dextromethorphan hydrobromide, guaifenesin and chlorpheniramine maleate; the method uses high performance liquid chromatography (HPLC) to detect the drug sample, wherein the mobile phase of HPLC comprises a mobile phase A which is an aqueous solution containing trifluoroacetic acid of which the concentration is 0.1v / v% and a mobile phase B which is a mixed solution of acetonitrile and methanol in a volume ratio of 60: 40. The detection method provided by the invention can simply and quickly detect the six active components in the drug sample simultaneously, and the six active components can be separatedeffectively, and the detection method is simply operated, and quickly analyzed, suitable for detection of most cold medicines and wide in detection application range.

Description

Technical field [0001] The present invention relates to the field of medicine. Specifically, the present invention relates to a method for detecting six active ingredients in a drug sample. Background technique [0002] Cold, as one of the most common respiratory diseases, there are many kinds of treatment drugs. Among them, western medicine is favored by people because of its transparency and quick effect. Cold medicines are mostly compound preparations. The composition of western medicines mainly includes the following types of drugs: antipyretic analgesics, adrenergic receptor agonists, antihistamines, antitussive and expectorants, and so on. [0003] At present, there is no public report on the method for simultaneously determining the content of multiple active ingredients in cold medicine. Therefore, the establishment of a scientific and effective analysis method that can simultaneously determine the content of the main components in cold medicines has important application ...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 徐欣秦巨波代蕾黄芸陈艳华晓维余爽
Owner HUMANWELL PURACAP PHARM WUHAN CO LTD
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