Extraction method of total salvianolic acids

Abstract

The invention discloses an extraction method of total salvianolic acids. The method comprises the following steps of (1) treating a radix salviae miltiorrhizae material; (2) carrying out alcohol extraction on radix salviae miltiorrhizae; (3) carrying out aqueous extraction on a radix salviae miltiorrhizae alcohol extract: taking out medicine dregs obtained through alcohol extraction for decocting,and repeatedly decocting; (4) drying a radix salviae miltiorrhizae aqueous extract; (5) purifying the radix salviae miltiorrhizae aqueous extract: weighing 40g of radix salviae miltiorrhizae aqueousextract, adding 300mL of water, carrying out sonic oscillation treatment to prepare into an aqueous solution, selecting a macroporous adsorbent resin material, and shaking out at constant temperaturethrough water bath for 24H; (6) drying the total salvianolic acids, and obtaining a purified total salvianolic acids effective extract. Through the combination of alcohol extraction and aqueous extraction, liposoluble tanshinone and water-soluble phenolic acids of the radix salviae miltiorrhizae are extracted, so that the extracting purity of the total salvianolic acids is improved, the waste of materials is reduced, and the occurrence of the phenomenon that acid water causes the volatilization of salvianolic acid substances during an aqueous extraction process is avoided since the extractionis carried out through pure water.

Description

technical field [0001] The invention relates to the technical field of extracting total phenolic acids of salvia miltiorrhiza, in particular to a method for extracting total phenolic acids of salvia miltiorrhiza. Background technique [0002] Salvia miltiorrhiza is a traditional Chinese medicine commonly used in clinical treatment of cardiovascular and cerebrovascular diseases, and has a significant curative effect, and has a long history of clinical application. [0003] In recent years, the water-soluble components of Salvia miltiorrhiza have been systematically studied, and salvianolic acids A, B, C, D, E, F, G, H, I, J, rosmarinic acid, shikonin, isodan Phenolic acid compounds such as phenolic acid and glucoside of rosmarinic acid. Pharmacological experiments show that the water-soluble components of Danshen are the important active ingredients of Danshen, and they play an important role in the effects of Danshen. According to recent research results, free radicals are...

AI Technical Summary

Problems solved by technology

[0007] (1) Extracting the total phenolic acids of salvia miltiorrhiza by a single alcohol extraction method, resulting in a lot of waste of raw materials, unable to extract water-soluble phenolic acid components;

[0008] (2) The process of acid water extraction is not easy to control, and it is easy to cause the thermal instability of the total phenolic acids of salvia miltiorrhiza in the extraction process, resulting in a lot of phenolic acid loss

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