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Antibacterial compositions and methods

A bacterial infection and pharmacy technology, applied in the direction of antibacterial drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve the problems of expensive and new antibacterial agent resistance

Pending Publication Date: 2018-03-27
WOCKHARDT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the development of new antimicrobials can be expensive and may not always be a permanent solution, as bacteria tend to become resistant to new antimicrobials after a short time

Method used

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  • Antibacterial compositions and methods

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Embodiment Construction

[0081]The following examples illustrate the presently best known embodiments of the invention. However, it should be understood that the following content is merely an example or illustration of the application of the principles of the present invention. Numerous modifications and substitutions in compositions, methods and systems may be made by those skilled in the art without departing from the spirit and scope of the invention. The appended claims are intended to cover such modifications and permutations. Thus, while the invention has been described in detail above, the following examples provide additional details regarding what are presently considered to be the most practical and preferred embodiments of the invention.

[0082] The efficacy of the method of the invention was studied using a neutropenic mouse model of lung infection at doses equivalent to the clinical dose of 2 grams of cefepime and 2 grams of tazobactam q8h (every 8 hours) and infused over 30-90 minutes...

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Abstract

A method for treating bacterial infection using: (a) cefepime or a pharmaceutically acceptable salt thereof, (b) arginine or a pharmaceutically acceptable salt thereof, and (c) tazobactam or a pharmaceutically acceptable salt thereof is disclosed.

Description

[0001] Related Patent Applications [0002] This application claims priority from Indian Patent Application No. 201621011248 filed on March 31, 2016, the disclosure of which is incorporated herein by reference in its entirety as if rewritten in its entirety herein. field of invention [0003] The present invention relates to antimicrobial compositions and methods for treating, controlling or preventing bacterial infections. Background technique [0004] Infections caused by bacteria remain an area of ​​serious concern worldwide. One of the key challenges in treating, controlling or preventing bacterial infections is the ability of bacteria to develop resistance to one or more antimicrobial agents over time. Representative examples of such bacteria resistant to typical antimicrobial agents include penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococci, and methicillin-resistant Staphylococcus aureus ( Staphylococcus aureus). The problem of emergin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/497A61K31/43A61P31/04
CPCA61K31/43A61K31/497A61K31/198A61K31/431A61K31/546A61P31/04A61P43/00A61K9/0019A61K47/183A61K2300/00
Inventor M·V·帕特尔S·布哈格瓦特S·S·塔卡尔卡R·沙旺K·乌玛卡
Owner WOCKHARDT LTD