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MiRNA marker relevant with colorectal cancer prognosis and application of miRNA marker

A colorectal cancer and marker technology, applied in the fields of biotechnology and medicine, can solve the problems of high complications, difficult to become a patient with colorectal cancer liver metastases, insufficient typical indications, etc., to achieve pain relief, easier access, and convenience. effect used

Inactive Publication Date: 2018-04-06
广西壮族自治区肿瘤防治研究所
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Problems solved by technology

[0006] Traditional screening methods such as laparoscopy, fine-needle aspiration cytology and imaging methods such as enhanced computed tomography (CT), magnetic resonance imaging (MRI) are invasive, high in complications or insufficient in typical indications, Therefore, it is difficult to become an effective method for early screening of patients with colorectal cancer liver metastases

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  • MiRNA marker relevant with colorectal cancer prognosis and application of miRNA marker
  • MiRNA marker relevant with colorectal cancer prognosis and application of miRNA marker
  • MiRNA marker relevant with colorectal cancer prognosis and application of miRNA marker

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Embodiment Construction

[0028] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0029] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0030] Part I: Bioinformatics analysis and screening of miRNAs associated with colorectal cancer metastasis

[0031] Materials and Methods

[0032] 1. Technical methods and data analysis process (see figure 1 )

[0033] 2. Acquisition of miRNA and gene expression data

[0034] The search keywords of this study in the GEO database are "Colorectal cancer", "Colon cancer", "rectal cancer", "Colonic carcinoma", "Metastasis", "Hepatic metastasis", "livermetastasis", "MicroRNAs". In addition, Google Scholar and Baidu Academic wer...

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Abstract

The invention discloses a miRNA marker relevant with colorectal cancer prognosis and application of the miRNA marker. The miRNA marker is miR-96 or miR-155 in plasma and is miR-99b in tissues. MiRNA which is relevant with colorectal cancer prognosis and screen by the invention can be taken a noninvasive marker for the colorectal cancer prognosis, and an important theoretical basis is provided forthe clinical application of miRNA.

Description

technical field [0001] The invention relates to the fields of biotechnology and medical technology. More specifically, the present invention relates to a miRNA marker related to the prognosis of colorectal cancer and its application. Background technique [0002] Colorectal cancer (CRC) is one of the most common gastrointestinal cancers and the third leading cause of cancer-related death worldwide. The occurrence of colorectal cancer liver metastasis is a multifactorial and multistep process. Approximately 20–25% of CRC patients are initially diagnosed with liver metastases, and up to 40–50% of patients develop liver metastases after primary tumor resection. Most patients with colorectal liver metastases are not suitable for radical surgical resection, and the five-year survival rate is ≤10%. [0003] The occurrence of liver metastasis in colorectal cancer patients is not only related to abnormal or loss of expression of proto-oncogenes and tumor suppressor genes, but als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 张力图利基林宁淑芳刘海洲陈伊韦文娥蔡政民苏程琳
Owner 广西壮族自治区肿瘤防治研究所
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