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Radix isatidis and folium isatidis granules with good curative effect and preparation method of radix isatidis and folium isatidis granules
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A technology of granules and banqing, which is applied in the field of banqing granules and its preparation, can solve the problems of large loss of active ingredients, influence on drug efficacy, complicated process, etc., and achieve the effects of fast dissolution, high antibacterial activity and good curative effect
Inactive Publication Date: 2018-04-13
江西纵横生物科技有限公司
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Problems solved by technology
However, the loss of active ingredients in the medicinal materials by decoction is relatively large, which will affect the efficacy to a certain extent.
Other methods, such as percolation method, reflux method, compound enzyme method, etc., have disadvantages such as high cost and complicated process.
Method used
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Embodiment 1
[0013] Embodiment 1: A preparation method of Isatidis granules with good curative effect, comprising the following steps: mixing 900 parts by weight of Folium Folium Isatidis and 600 parts by weight of Radix Radix Radix, then adding water 10 times its total weight, adding after boiling Sodium tripolyphosphate, chitosan, betaine, then decoct twice at 100°C, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add sucrose and dextrin, mix well, make granules, and dry , made into 1500g, you can.
[0014] The molecular weight of the chitosan is 50,000-180,000, and the dosage is 2.5% of the weight of Folium folium;
[0015] The consumption of described sodium tripolyphosphate is 0.2% of Folium Folium weight;
[0016] The consumption of described betaine is 0.3% of Folium Folium weight;
Embodiment 2
[0017] Embodiment 2: the difference with embodiment 1 is:
[0018] The molecular weight of the chitosan is 50,000-180,000, and the dosage is 2% of the weight of Folium folium;
[0019] The consumption of described sodium tripolyphosphate is 0.5% of Folium Folium weight;
[0020] The consumption of described betaine is 0.5% of Folium Folium weight;
[0021] All the other are with embodiment 1.
Embodiment 3
[0022] Embodiment 3: the difference with embodiment 1 is:
[0023] The molecular weight of the chitosan is 50,000-180,000, and the dosage is 3% of the weight of Folium folium;
[0024] The consumption of described sodium tripolyphosphate is 0.1% of Folium Folium weight;
[0025] The consumption of described betaine is 0.1% of Folium Folium weight;
[0026] All the other are with embodiment 1.
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Abstract
The invention provides a banqing granule with good curative effect and a preparation method thereof. The antibacterial ability of the banqing granule to pathogenic strains such as Streptococcus suis and Escherichia coli is greatly improved. The present invention has added betaine, chitosan of small molecular weight, sodium tripolyphosphate in the process of decocting and extracting, and compared with the conventional technique recorded on the Chinese Pharmacopoeia, the Banqing granules obtained after these treatments are less harmful to livestock and poultry. The antibacterial activity of pathogens was significantly improved. In addition, we found that adjusting the order of adding betaine, chitosan and sodium tripolyphosphate, that is, adding sodium tripolyphosphate first, then adding chitosan, and finally adding betaine, can speed up the solubility of Banqing granules. It can be completely dissolved after stirring for 1 minute; at the same time, the antibacterial effect of Banqing granules on porcine bronchiseptica Bordetella and Escherichia coli can be further improved.
Description
technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to Banqing granules with good curative effect and a preparation method thereof. Background technique [0002] Banqing granule is a pure traditional Chinese medicine preparation with Radix isatidis and Folium japonicus as the main ingredients. It has the functions of clearing away heat, detoxifying and cooling blood. Banqing granules are suitable for swine influenza, circovirusdisease, blue ear disease, chicken atypical Newcastle disease, infectious bursal disease, infectious laryngotracheitis, influenza, etc., especially suitable for hot summer, high temperature and high humidity Animal febrile disease caused by etc. [0003] At present, the production process of Isatidis granules is generally to mix Radix Radix Isatidis and Folium Folium Folium and then decoct, and the thick paste obtained by concentrating the filtrate is mixed with au...
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