Dibenzofuran derivative as well as preparation method and application thereof

Abstract

The invention discloses a compound of formula i as shown in the specification, or a stereisomer, a pharmaceutically acceptable salt, a solvate, a prodrug or a metabolite of the compound. In the formula, R1, R2, R3 and R4 are respectively independently hydroxyl, sulfydryl, carboxyl, amino, C1-C4 alkyl or C1-C4 alkoxy. The invention provides a completely novel compound of the formula i as shown in the specification. The compound has a relatively good anti-rheumatoid arthritis function, and a novel option is provided for clinical screening and / or preparation of anti-rheumatoid arthritis medicines.

Description

technical field

[0001] The invention relates to a dibenzofuran derivative, a preparation method and application thereof. Background technique

[0002] Bauhinia championi (Benth.) Benth is a woody vine of the genus Bauhinia championi (Benth.) Benth. etc., distributed in Zhejiang, Jiangxi, Fujian, Guangdong, Guangxi, Hunan, Hubei, Guizhou and other provinces and regions, its nature is flat, bitter, non-toxic, has the effect of expelling wind and dampness, promoting qi and blood circulation, and is clinically used to treat rheumatic joints It is mainly used to treat epigastric pain, rheumatic joint pain, acute and chronic lumbago and leg pain among the people.

[0003] Although the Asparagus vine plant has a good curative effect, it has not been fully researched and developed. Further clarification of the components of Asparagus chinensis will lay a certain theoretical foundation for the further use of Asparagus genus plant resources in the future to develop drugs with clear ...

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