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A kind of composite antibacterial aerosol and its preparation method and application

A technology for compounding antibacterial and aerosol agents, applied in the field of antibacterial agents, can solve the problems of complex antibacterial agent ingredients, cumbersome preparation process, single antibacterial effect, etc., and achieves the effect of simple formula, simple process, and improved microcirculation

Active Publication Date: 2020-11-10
青岛市中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a compound antibacterial aerosol and its preparation method and application, which solves the problems of complex antibacterial composition, single antibacterial effect and poor antibacterial effect in the prior art, as well as cumbersome preparation procedures, high cost and low efficiency. question

Method used

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  • A kind of composite antibacterial aerosol and its preparation method and application
  • A kind of composite antibacterial aerosol and its preparation method and application
  • A kind of composite antibacterial aerosol and its preparation method and application

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preparation example Construction

[0030] A preparation method of a composite antibacterial aerosol, comprising the following steps: a) Weigh chitosan diquaternary ammonium salt, nano-sized titanium dioxide, sea salt and sodium hyaluronate, and mix them to obtain a mixture; b) obtained in step a) To the mixture, add purified water and stir to make it fully dissolved to obtain a composite antibacterial aerosol.

[0031] An application of a composite antibacterial aerosol. The aerosol is used for nasal cavity, oral cavity and postoperative cleaning. The aerosol is used for cleaning the nasal cavity or oral cavity with congestion. The weight percentage of sea salt When the aerosol is more than 0.9% and not more than 2.2%, when the aerosol is used for daily care of the nasal cavity or oral cavity and cleaning and care of postoperative wounds, the weight percentage of sea salt is 0.9%.

Embodiment 1

[0033] A preparation method of chitosan diquaternary ammonium salt, including the following steps: weighing chitosan (degree of deacetylation 97%, average molecular weight 2.5×10 5 ) 163g, placed in an autoclave, add 453g 2,3-epoxypropyltrimethylammonium chloride, 100g polyethylene glycol 400 and 1 liter of purified water, heat to 120℃, stir for 12h, after the reaction is complete , Cooling it to 25℃, extracting three times with ether (1L×3), adding 0.5L acetone to the water phase, slowly cooling to 0℃ under stirring, stirring for 2h, during the process, the product gradually precipitates and filtering with suction; Stir and wash and dry under vacuum to obtain chitosan diquaternary ammonium salt.

[0034] The yield of the obtained chitosan diquaternary ammonium salt is 395g, the yield is 85%, and the structural formula is:

[0035]

Embodiment 2

[0037] A preparation method of composite antibacterial aerosol includes the following steps:

[0038] 1) Weigh 3.0 g of the chitosan diquaternary ammonium salt prepared in Example 1, and successively weigh 0.3 g of nano-sized titanium dioxide, 0.50 g of sodium hyaluronate and 2.2 g of sea salt, and mix to obtain a mixture;

[0039] 2) In the above mixture, add purified water to a total weight of 100 g, stir to fully dissolve each component, and obtain 100 g of composite antibacterial aerosol.

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Abstract

The invention discloses a composite antibacterial aerosol as well as a preparation method and application thereof and belongs to the technical field of antibacterial agents. The composite antibacterial aerosol disclosed by the invention contains the following raw materials in percentage by weight: 0.5-3.0% of chitosan biquaternary ammonium salt, 0.05-0.3% of nano titanium dioxide, 0.9-2.2% of a sea salt and the balance of purified water. The invention further discloses a preparation method of the aerosol. The preparation method comprises the following steps: uniformly mixing the chitosan biquaternary ammonium salt, the nano titanium dioxide and the sea salt, adding the purified watrer, and enabling the materials to be fully dissolved, thereby obtaining the aerosol. The aerosol can be applied to cleaning of the nasal cavity and oral cavity and postoperative cleaning. The aerosol disclosed by the invention is simple in formula, low in cost, excellent in biocompatibility, simple in preparation method, obvious in antibacterial and bacteriostatic effects, safe and non-irritating, and achieves the effects of relieving inflammations of the nasal cavity and oral cavity, keeping the nasal mucosa and oral cavity wet, eliminating postoperative peripheral inflammation, preventing and controlling wound infection, promoting regeneration and repair of the mucous membranes and tissues and promoting wound healing.

Description

Technical field [0001] The invention belongs to the technical field of antibacterial agents, in particular to a composite antibacterial aerosol and its preparation method and application. Background technique [0002] Chitosan, a natural polymer, has excellent properties such as biocompatibility, non-toxicity, antibacterial activity and microbial degradability. However, chitosan has good solubility in acidic solutions and is difficult to dissolve in water. This property limits Its scope of application. At present, the research on the modification of chitosan is mainly in C 2 -NH 2 The quaternary ammonium salt structure is introduced into the group. The quaternary ammonium salt of chitosan obtained after chemical modification has good biocompatibility, not only has good water solubility, antibacterial properties, film-forming properties, and cation adsorption properties. , Hygroscopicity, moisture retention, flocculation and antistatic properties. It also has excellent properties...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/24A61K9/12A61K47/36A61P31/02A61P1/02A61P11/02A61P17/02C08B37/08A61K31/722A61K33/14A61K31/728
CPCA61K9/0014A61K9/0043A61K9/006A61K9/12A61K31/722A61K31/728A61K33/14A61K33/24A61K47/36C08B37/003A61K2300/00
Inventor 宋磊解春霞
Owner 青岛市中医医院
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