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A kind of pharmaceutical composition for treating malaria

A composition and drug technology, applied in the field of pharmacy, can solve problems such as no cure for malaria, and achieve the effects of increasing blood supply to the brain, reducing cerebral blood vessel blockage, and improving symptoms of nerve damage

Active Publication Date: 2021-01-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once malaria parasites develop resistance to current ACTs on a large scale, malaria will face the dilemma of no cure, and the development of new compound antimalarial drugs will face major challenges

Method used

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  • A kind of pharmaceutical composition for treating malaria
  • A kind of pharmaceutical composition for treating malaria
  • A kind of pharmaceutical composition for treating malaria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Embodiment 1, pharmaceutical composition of the present invention

[0133] Artesunate 40mg, ligustrazine hydrochloride 20mg

[0134] (1) Take 40mg artesunate, add 1ml 0.9% sodium chloride injection, dissolve completely, then add 3ml 0.9% sodium chloride injection to dilute,

[0135] (2) Take 20mg ligustrazine hydrochloride, add 4ml of 0.9% sodium chloride injection and shake until completely dissolved,

[0136] (3) Mix the solutions obtained in the above two steps evenly.

Embodiment 2

[0137] Embodiment 2, pharmaceutical composition of the present invention

[0138] Artesunate 20mg, ligustrazine hydrochloride 20mg

[0139] (1) Take 20mg artesunate, add 1ml 0.9% sodium chloride injection, dissolve completely, then add 1ml 0.9% sodium chloride injection to dilute,

[0140] (2) Take 20mg ligustrazine hydrochloride, add 4ml of 0.9% sodium chloride injection and shake until completely dissolved,

[0141] (3) Mix the solutions obtained in the above two steps evenly.

Embodiment 3

[0142] Embodiment 3, pharmaceutical composition of the present invention

[0143] Artesunate 20mg, ligustrazine hydrochloride 40mg

[0144] (1) Take 20mg artesunate, add 1ml 0.9% sodium chloride injection, dissolve completely, then add 1ml 0.9% sodium chloride injection to dilute,

[0145] (2) Take 40mg ligustrazine hydrochloride, add 8ml of 0.9% sodium chloride injection and shake until completely dissolved,

[0146] (3) Mix the solutions obtained in the above two steps evenly.

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Abstract

The invention belongs to the field of pharmacy and relates to a traditional Chinese medicine composition, in particular to a pharmaceutical composition for treating malaria. The medicine of the invention has the characteristics of good curative effect, quick effect, stable quality, and can improve the symptoms of nerve damage. The pharmaceutical composition of the present invention contains artesunate, ligustrazine or a medicinal salt thereof, and their weight ratio is 1-10:10-1.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a traditional Chinese medicine composition, in particular to a medicinal composition for treating malaria. Background technique [0002] Malaria is a major infectious disease that seriously threatens human health and life safety. It spreads and prevails in 108 countries and regions around the world. About half of the world's population is threatened by malaria. It is one of the three major public health problems in the world. According to WHO's 2016 World Malaria Report, about 3.2 billion people (accounting for nearly half of the world's total population) are at risk of malaria. In 2015, there were 214 million new cases of malaria, and about 438,000 people died of malaria. At the same time, the drug resistance of Plasmodium also poses a serious challenge to malaria drug treatment. In order to improve clinical efficacy and delay the emergence of drug resistance, WHO has promoted artemisinin-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61K9/08A61P33/06A61P25/00A61P9/10A61K31/357
CPCA61K47/02A61K9/0043A61K9/08A61K31/357A61K31/4965A61K2300/00A61K9/127A61P33/06Y02A50/30
Inventor 朱晓新李玉洁沈硕陈利娜蔡维艳翁小刚谷丽维杨庆李凯姜晓慧郭媛
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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