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Flow control method and device, analysis instrument, and computer-readable storage medium

A flow control and flow value technology, applied in the field of medical devices, can solve the problems of increasing the dead volume of the mobile phase and reducing the accuracy of sample analysis

Active Publication Date: 2019-11-29
MACCURA MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, increasing the number of plungers or increasing the damper will increase the dead volume of the mobile phase, that is, the void volume in the column that is not occupied by the stationary phase, resulting in a decrease in the analysis accuracy of the sample

Method used

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  • Flow control method and device, analysis instrument, and computer-readable storage medium
  • Flow control method and device, analysis instrument, and computer-readable storage medium
  • Flow control method and device, analysis instrument, and computer-readable storage medium

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specific Embodiment approach

[0133] The specific implementation method is: obtaining the maximum pressure value in the pressure range where the pressure value loaded in the chromatographic column is located in the current analysis cycle of the chromatographic column. If the pressure value loaded in the chromatographic column reaches the maximum pressure value, it is judged whether the chromatographic column is in the equilibrium period, and the analysis results of the chromatographic column during the equilibrium period are not affected by the flow jump of the high-pressure constant-flow pump.

[0134] In one example, if the chromatographic column is in the equilibrium period, then according to one or more characteristic spectra and the fifth flow curve, the rotational speed of the motor in the high-pressure constant-flow pump is controlled so that the output flow value of the high-pressure constant-flow pump reaches the next pressure range Desired control flow value.

[0135] In another example, if the c...

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Abstract

The embodiment of the invention discloses a flow control method and a device, an analytical instrument and a computer readable storage medium. The flow control method includes: acquiring one or more characteristic spectra in one stroke cycle of a high pressure constant flow pump, with each characteristic spectrum corresponding to a wave peak or wave trough in a first flow curve; according to an initial flow value and a second flow curve of the high pressure constant flow pump, acquiring a third flow curve of the high pressure constant flow pump, wherein the second flow curve is used for indicating the relationship between the output flow of the high pressure constant flow pump and the loading pressure in a chromatographic column, and the third flow curve is used for indicating the relationship between the compensation flow required by the high pressure constant flow pump and the loading pressure in the chromatographic column; and according to one or more characteristic spectra, the second flow curve and the third flow curve, and controlling the rotation speed of a motor in the high pressure constant flow pump to make the output flow value of the high pressure constant flow pump toapproach the initial flow value. The technical scheme adopted by the embodiment of the invention can make the output flow of the high pressure constant flow pump tend to be constant.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a flow control method and device, an analysis instrument and a computer-readable storage medium. Background technique [0002] Compositional analysis is the main purpose of medical analytical instruments, such as hemoglobin analyzers. The output end of the high-pressure constant-flow pump is connected to the chromatographic column. The working principle of the high-pressure constant-flow pump is: to use the reciprocating motion of the plunger in the high-pressure constant-flow pump to make the high-pressure constant-flow pump alternately absorb and discharge liquid in each stroke cycle , to input the mobile phase from the reagent bottle to the column. Whether the output flow rate of the high-pressure constant-flow pump is constant or not during the entire test process directly affects the accuracy of the test results of the analytical instrument. At present, there are two indicat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/28G01N30/32
CPCG01N30/28G01N30/32G01N2030/285
Inventor 杨建华陆辉
Owner MACCURA MEDICAL INSTR CO LTD