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Traditional Chinese medicine composition with oat and trehalose and preparation method thereof

A composition, trehalose technology, applied in the directions of drug combination, pharmaceutical formulation, antitumor drug, etc., can solve problems such as no application report, achieve tumor multidrug resistance reversal, good tumor multidrug resistance, and preparation technology Easy to use effect

Inactive Publication Date: 2018-06-22
GUANGZHOU GUOYU MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the composition of Epingcao, Juniper japonica, longan leaf, oat and trehalose and its application in reversing tumor multidrug resistance

Method used

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  • Traditional Chinese medicine composition with oat and trehalose and preparation method thereof
  • Traditional Chinese medicine composition with oat and trehalose and preparation method thereof
  • Traditional Chinese medicine composition with oat and trehalose and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 A traditional Chinese medicine oat trehalose composition

[0022] (1) The preparation method is as follows:

[0023] 1) Weigh Eping grass (100g), Juniper (100g), longan leaves (50g) and oats (200g) and mix them thoroughly. After refluxing pretreatment with 70% ethanol solution, add 2 times the amount of distilled water and 0.01 Double the amount of α-amylase with good thermal stability. After heating and decocting at 90°C for 2 hours, add an appropriate amount of sodium hydroxide solution to adjust the pH of the solution to about 8, extract again at 50°C for 5 hours, and finally use 50% The ethanol solution precipitates insoluble matter, dissolves the insoluble matter in distilled water, and adds 100 g of trehalose to form a water-soluble composition solution as the water phase;

[0024] 2) Dissolve an appropriate amount of polylactic acid-glycolic acid copolymer in hot ethanol, heat and stir evenly at 55°C, as the oil phase;

[0025] 3) Take an appropriate amount of...

Embodiment 2

[0066] Example 2 A kind of traditional Chinese medicine oat trehalose composition

[0067] (1) The preparation method is as follows:

[0068] 1) Weigh Eping grass (200g), mountain juniper (150g), longan leaf (150g) and oats (30g) and mix them thoroughly. After refluxing pretreatment with 80% ethanol solution, add 2 times the amount of distilled water and 0.01 Double the amount of α-amylase with good thermal stability. After heating and decocting at 90°C for 2 hours, add an appropriate amount of sodium hydroxide solution, adjust the pH of the solution to about 10, and extract again at 50°C for 5 hours, and finally use 50% The ethanol solution precipitates insoluble matter, dissolves the insoluble matter in distilled water, and adds trehalose (150g) to form a water-soluble composition solution as the water phase;

[0069] 2) Dissolve an appropriate amount of polylactic acid-glycolic acid copolymer in hot ethanol, heat and stir evenly at 50°C, as the oil phase;

[0070] 3) Take an appro...

Embodiment 3

[0074] Example 3 A traditional Chinese medicine oat trehalose composition

[0075] (1) The preparation method is as follows:

[0076] 1) Weigh Eping grass (150g), mountain juniper (250g), longan leaves (200g) and oats (400g) and mix them thoroughly. After refluxing pretreatment with 75% ethanol solution, add 2 times the amount of distilled water and 0.01 Double the amount of α-amylase with good thermal stability. After heating and decocting at 90°C for 2 hours, add an appropriate amount of sodium hydroxide solution, adjust the pH of the solution to about 9, extract again at 50°C for 5 hours, and finally use 50% The ethanol solution precipitates insoluble matter, dissolves the insoluble matter in distilled water, and adds trehalose (150g) to form a water-soluble composition solution as the water phase;

[0077] 2) Dissolve an appropriate amount of polylactic acid-glycolic acid copolymer in hot ethanol, heat and stir evenly at 60°C, as the oil phase;

[0078] 3) Take an appropriate amo...

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Abstract

The invention relates to a traditional Chinese medicine composition and a preparation method thereof. The invention adopts the technical scheme that the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of tanakaea omeiensis, 10-30 parts of juniperus formosana, 5-20 parts of longan leaf, 20-40 parts of oat and 10-20 parts of trehalose. The traditional Chinese medicine composition is prepared by the steps: killing endogenous enzymes of five raw materials by an organic solvent, removing fat-soluble components, removing polar substances, degrading starch by using alpha-amylase, precipitating non-starch polysaccharides by using alcohol and the like. The traditional Chinese medicine composition has the effect of reversing multi-drug resistance of the tumor.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for reversing tumor multidrug resistance and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] In recent years, the incidence and mortality of tumors have been increasing year by year. Studies have shown that more than 85% of the deaths of tumor patients are affected by tumor multidrug resistance to varying degrees. Tumor drug resistance can be divided into primary drug resistance and acquired drug resistance. According to the characteristics of tumor cell resistance, the acquired drug resistance can be divided into two categories: original drug resistance and multidrug resistance. Multidrug resistance is the main reason for the failure of tumor chemotherapy, and it is also a major problem that plagues tumor treatment. Therefore, overcoming the multi-dr...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P35/00A61K31/7016
CPCA61K31/7016A61K36/14A61K36/185A61K36/77A61K36/899A61K2236/19A61K2236/333A61K2300/00
Inventor 黄英红李倩文余绍蕾唐昊杨智超
Owner GUANGZHOU GUOYU MEDICAL TECH
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