Component proportions and screening method of chemical components of sodium aescinate

Abstract

The invention relates to component proportions and a screening method of chemical components of sodium aescinate and relates to the field of pharmacy. The screening method comprises the following steps: obtaining sodium aescinate samples with different component proportions; performing detection to obtain a chemical fingerprint chromatogram of the samples, the dosage of the samples to test bodiesas well as corresponding irritation test data and pharmacodynamic test data; performing grey correlation analysis to obtain a first analytic result of an irritation sequence and a pharmacodynamic sequence of all components of the sodium aescinate; constructing a neural network by taking the dosage as an input layer and taking the irritation test data and the pharmacodynamic test data which are subjected to normalized weighting treatment as an output layer; predicting all components of the sodium aescinate by using the trained neural network, and then, performing comparison with the first analytic result; and performing screening and verification. The component proportions and the screening method provided by the invention have the advantages that the screening is fast and effective, the screening time is effectively shortened, the screening cost is lowered, sodium aescinate chemical components with low irritation and good pharmacodynamic effects are obtained, and medicinal effects andclinical compliance are improved.

Description

technical field [0001] The present invention relates to the field of pharmacy, and particularly relates to a escin sodium chemical component composition ratio and a screening method thereof. Background technique [0002] The complex chemical composition is a common feature of traditional Chinese medicine, ethnic medicine, natural medicine, etc., and the identification and quality control of effective substances / adverse reaction source substances are common difficulties; the traditional methods of separating components and evaluating the activity / toxicity of single components one by one work load large, low efficiency, and ignore the overall characteristics and interactions between components, which is no longer suitable for the development needs of system medicine, precision medicine and medical big data; the present invention takes sodium aescinate as an example to provide a component separation Combination, a new strategy for the identification of effective substances / irri...

AI Technical Summary

Problems solved by technology

However, the irritation problem (vascular irritation) is a common problem that plagues the clinical application of sodium aescinate for injection

It is reported that more than 80% of the patients who use this product have varying degrees of phlebitis, and more severe cases terminate the treatment due to unbearable pain, which seriously restricts the popularization and application of the product

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