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Self-adhesive dura mater patch and preparation method thereof

A production method and self-adhesive technology, applied in the field of neurosurgery, can solve the problems of insufficient adhesive strength, insufficient elasticity and toughness, and lack of self-adhesive artificial dura mater, so as to improve water tightness, reduce requirements, and avoid damage to brain tissue. the effect of the possibility of

Pending Publication Date: 2018-07-13
鹏拓生物科技杭州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Artificial dura mater has certain elasticity, toughness and strength, but the existing artificial dura mater only pursues non-tissue stickiness in the process of design and production.
Existing medical adhesives often have insufficient bonding strength, or insufficient elasticity and toughness
[0008] At present, there is a lack of a simple and convenient self-adhesive artificial dura mater, so as to shorten the time and simplify the procedure when repairing the dura mater, and at the same time, it can be conveniently bonded to repair the dura mater defect at the site where suturing is inconvenient

Method used

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  • Self-adhesive dura mater patch and preparation method thereof
  • Self-adhesive dura mater patch and preparation method thereof
  • Self-adhesive dura mater patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] see Figure 1-4 As shown, a self-adhesive dura mater patch includes a base and an adhesive layer coated on the surface of the base, the base is an artificial dura mater 1, and the self-adhesive dura mater patch is pasted directly through the adhesive layer. The adhesive layer is a pressure-sensitive adhesive 2, and the pressure-sensitive adhesive 2 can be selected from non-toxic and harmless acrylic pressure-sensitive adhesives, polyurethane pressure-sensitive adhesives, silicone pressure-sensitive adhesives, thermoplastic elastomer pressure-sensitive adhesives, and rubber-type pressure-sensitive adhesives. or other pressure sensitive adhesives. Since the adhesive force formed between the pressure-sensitive adhesive 2 human tissue and the artificial dura mater 1 is mainly van der Waals force, after the adhesive surface is formed, the structure of the adhesive surface is not destroyed and has little effect on human tissue.

[0037] The components of this application are...

Embodiment 2

[0044] The artificial dura mater 1 is made of absorbable collagen sponge, the pressure-sensitive adhesive 2 is made of methyl vinyl silicone gel pressure-sensitive adhesive, and the release paper 3 is made of polytetrafluoroethylene film. Mix the two-component methylvinyl silicone pressure-sensitive adhesive AB two components 1:1, vacuum defoam, brush the glue on the 5mm thick collagen sponge, the thickness of the glue layer is 0.02-0.03mm, bake at 120° for 10 Cool for 1 minute, apply on a 0.1mm thick polytetrafluoroethylene film after cooling, and use after disinfection.

[0045] Silicone rubber has great biological inertia and strong compatibility in human tissue. It is not easy to degrade in long-term contact with human tissue and secretions, and can withstand large temperature differences.

[0046] The 180° surface peeling force of the measured sample is 60±1g / 25mm, which meets the surgical requirements.

[0047] The self-adhesive dural patch prepared by the above method ...

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Abstract

The invention discloses a self-adhesive dura mater patch. The patch comprises a substrate and an adhesive layer coating the surface of the substrate, and the substrate is an artificial dura mater. Theinvention further discloses a preparation method of the dura mater patch. The preparation method of the dura mater patch comprises the steps that 1, the surface of the artificial dura mater is coatedwith an adhesive to form the adhesive layer; 2, after drying, isolation paper adheres to the adhesive layer; 3, the product is disinfected and stored for use. The self-adhesive dura mater patch has the advantages that the artificial dura mater and the pressure-sensitive adhesive are combined to produce the self-adhesive dura mater patch; the dura mater repair process in an operation is simplified, requirements for skills of doctors are reduced, and the water tightness of dura mater repaire is improved; the dura mater patch can be applied to the part where surgical suture is difficult and alsocan be applied to dua mater defect parts, and the problem that the hardness of binding parts is too large during adhension of alpha-cyanoacrylate is solved. The dura mater patch can also be used foradhesion of a skull and the dura mater to replace traditional dura mater suture, the possibility that a suture needle potentially damages brain tissue in the suspension process is avoided, and the operation time is shortened.

Description

technical field [0001] The invention relates to the technical field of neurosurgery, in particular to a self-adhesive dura mater patch and a manufacturing method thereof. Background technique [0002] Neurosurgery generally requires suturing for anatomical reduction of the incised dura (spinal) membrane. In the absence of dura (spinal) membrane defects, surgical sutures are generally used for suturing. If there is a dural (spinal) membrane defect, autologous tendons need to be used Membranes or artificial materials for repair. [0003] The suture repair of the dura mater requires watertight suture (that is, after the dura mater is sutured, water is injected under a certain pressure, and no water leakage is required at the suture). , Time-consuming and labor-intensive, skilled doctors generally need more than 20 minutes to complete the dura mater suture in the easy-to-suture parts, and some operations even need 30-40 minutes to complete the dura mater suture. If there is an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00C09J7/26C09J7/38C09J183/07
CPCA61F2/0063C09J2483/00C09J2489/006C09J2427/005A61F2220/005C09J2301/122C09J2301/302
Inventor 孟国路孟肇轩赵燕
Owner 鹏拓生物科技杭州有限公司
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