Method for regulating fluorescence lifetime of near-infrared core-shell structure nanocrystal

A core-shell structure, fluorescence lifetime technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problem of the inability to adjust the fluorescence lifetime of nanocrystals

Inactive Publication Date: 2018-07-13
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the technical problem that the fluorescence lifetime of nanocrystals doped with rare earth cannot be adjusted, and provides a method for adjusting the fluorescence lifetime of nanocrystals with a near-infrared core-shell structure.

Method used

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  • Method for regulating fluorescence lifetime of near-infrared core-shell structure nanocrystal
  • Method for regulating fluorescence lifetime of near-infrared core-shell structure nanocrystal
  • Method for regulating fluorescence lifetime of near-infrared core-shell structure nanocrystal

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specific Embodiment approach 1

[0021] Specific implementation mode one: the adjustment method of the near-infrared core-shell structure nanocrystal fluorescence lifetime of this embodiment is: the near-infrared core-shell structure rare earth doped nanocrystal is a cubic phase NaYF 4 :Yb,Nd,E@CaF 2 , Hexagonal NaYF 4 :Yb,

[0022] Nd,E@NaYF 4 , Hexagonal NaYF 4 :Yb,Nd,E@NaLuF 4 or hexagonal phase NaYF 4 :Yb,Nd,E@NaGdF 4 , where the fixed doping ions are Yb and Nd, the variable doping ions are E and E is Yb, Er, Ho, Tm or Nd; by changing the concentration of E ions to change the near-infrared core-shell structure of rare earth doped nanocrystals Fluorescence lifetime.

specific Embodiment approach 2

[0023] Specific embodiment two: this embodiment is different from specific embodiment one: variable doping ion E is Yb, improves E ion doping concentration, under the laser excitation of 800nm, near-infrared core-shell structure rare earth doping nanocrystal The fluorescence lifetime at 980nm emission is also enhanced. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0024] Specific embodiment three: the difference between this embodiment and specific embodiment one is: variable doping ion E is Nd ion, improves E ion doping concentration, under the laser excitation of 800nm, near-infrared core-shell structure rare earth doping nano The fluorescence lifetime of the crystal at 980nm emission is shortened. Others are the same as in the first embodiment.

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Abstract

The invention discloses a method for regulating the fluorescence lifetime of a near-infrared core-shell structure nanocrystal, and relates to a method for regulating the fluorescence lifetime of the near-infrared nanocrystal. The method solves the technical problem that the fluorescence lifetime of an existing rare earth doped nanocrystal cannot be regulated. The method comprises the following steps: enabling the near-infrared core-shell structure rare earth doped nanocrystal to be of a cubic phase NaYF4:Yb,Nd,E@CaF2, a hexagonal phase NaYF4:Yb,Nd,E@NaYF4, a hexagonal phase NaYF4:Yb,Nd,E@NaLuF4 or a hexagonal phase NaYF4:Yb,Nd,E@NaGdF4, wherein fixedly doped ions are Yb and Nd, a variably doped ion is E, and E is Yb, Er, Ho, Tm or Nd; and the fluorescence lifetime of the nanocrystal is regulated by changing the concentration of the E ion. The time gating imaging technology can be applied onto compound imaging by regulating the nanocrystals with different fluorescence lifetimes synthesized in a near-infrared region.

Description

technical field [0001] The invention relates to a method for adjusting the fluorescence lifetime of nanocrystals with a near-infrared core-shell structure. Background technique [0002] In recent years, with the development of bioimaging technology, biomedicine is constantly seeking new luminescent materials as optical probes to obtain high-resolution, high-contrast and high-penetration in vivo imaging. In the field of biomedicine, rare earth doped nanocrystals have great application prospects in biological imaging. Rare earth luminescent materials can absorb light in the near-infrared region and convert it to visible, ultraviolet, and near-infrared bands, which can be realized in biological imaging. Tissue optical window (near infrared region 1: 650-950, near infrared region 2: 1000-1350nm) imaging. In the near-infrared region, the absorption and scattering of light by biological tissues are greatly reduced, thereby improving the contrast of imaging and helping to visualiz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85C09K11/02
CPCC09K11/02C09K11/7773
Inventor 陈冠英谭美玲
Owner HARBIN INST OF TECH
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