152 results about "Time gating" patented technology

A medical imaging system is provided which includes a signal generator configured to obtain a trigger signal corresponding to a timing of interest, imaging equipment configured to obtain a plurality of images of a feature of interest, and a processor programmed to correlate the plurality of images with the trigger signal. Also provided is a method of correlating a plurality of medical images by obtaining a trigger signal of a timing of interest, obtaining a plurality of images of a feature of interest, and correlating the plurality of images with the trigger signal.

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

A medical imaging system is provided which includes a signal generator configured to obtain a trigger signal corresponding to a timing of interest, imaging equipment configured to obtain a plurality of images of a feature of interest, and a processor programmed to correlate the plurality of images with the trigger signal. Also provided is a method of correlating a plurality of medical images by obtaining a trigger signal of a timing of interest, obtaining a plurality of images of a feature of interest, and correlating the plurality of images with the trigger signal.

An active CMOS biosensor chip for fluorescent-based detection is provided that enables time-gated, time-resolved fluorescence spectroscopy. In one embodiment, analytes are loaded with fluorophores that are bound to probe molecules immobilized on the surface of the chip. Photodiodes and other circuitry in the chip are used to measure the fluorescent intensity of the fluorophore at different times. These measurements are then averaged to generate a representation of the transient fluorescent decay response unique to the fluorophores. In addition to its low-cost, compact form, the biosensor chip provides capabilities beyond those of macroscopic instrumentation by enabling time-gated operation for background rejection, easing requirements on optical filters, and by characterizing fluorescence lifetime, allowing for a more detailed characterization of fluorophore labels and their environment. The biosensor chip can be used for a variety of applications including biological, medical, in-the-field applications, and fluorescent lifetime imaging applications.

A Raman spectrometer that employs a time-gated single photon avalanche diode array as a sensor is described. The spectrometer can also perform fluorescence spectroscopy and laser induced breakdown spectroscopy (LIBS). A laser is used to provide an excitation signal to excite a specimen of interest. A spectrometer is used to separate the various intensities over a range of wavelengths, which are then caused to impinge on the array to be recorded. The time-gated single photon avalanche diode array is triggered in synchrony with the excitation signal so as to allow time resolution of the response of the sample of interest to the excitation. The array can be time-gated to resolve signals that have shorter durations as a function of time while excluding signals that have a longer time duration. Raman and LIBS signals can be observed even from specimens that fluoresce strongly.

Apparatus and method for amplifying laser signals using segments of fibers of differing core diameters and / or differing cladding diameters to suppress amplified spontaneous emission and non-linear effects such as four-wave mixing (FWM), self-phase modulation, and stimulated Brillouin and / or Raman scattering (SBS / SRS). In some embodiments, different core sizes have different sideband spacings (spacing between the desired signal and wavelength-shifted lobes). Changing core sizes and providing phase mismatches prevent buildup of non-linear effects. Some embodiments further include a bandpass filter to remove signal other than the desired signal wavelength and / or a time gate to remove signal at times other than during the desired signal pulse. Some embodiments include photonic-crystal structures to define the core for the signal and / or the inner cladding for the pump. Some embodiments include an inner glass cladding to confine the signal in the core and an outer glass cladding to confine pump light in the inner cladding.

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

An apparatus and method for enabling precise, 3-dimensional, photoactivation localization microscopy (PALM) using selective, two-photon activation of fluorophores in a single z-slice of a sample in cooperation with time-gated imaging for reducing the background radiation from other image planes to levels suitable for single-molecule detection and spatial location, are described.

Microwave imaging via space-time beamforming is carried out by transmitting microwave signals from multiple antenna locations into an individual to be examined and receiving the backscattered microwave signals at multiple antenna locations to provide received signals from the antennas. The received signals are processed in a computer to remove the skin interface reflection component of the signal at each antenna to provide corrected signal data. The corrected signal data is provided to a beamformer process that time shifts the received signals to align the returns from a scatterer at a candidate location, and then passes the time aligned signals through a bank of filters, the outputs of which are summed, time-gated and the power therein calculated to produce the beamformer output signal at a candidate location. The beamformer is then scanned to a plurality of different locations in the individual by changing the time shifts, filter weights and time-gating of the beamformer process. The output power may be displayed as a function of scan location, with regions of large output power corresponding to significant microwave scatterers such as malignant lesions.

A system for using a watermark embedded in an audio signal to remotely control a device. Various devices such as toys, computers, and appliances, equipped with an appropriate detector, detect the hidden signals, which can trigger an action, or change a state of the device. The watermarks can be used with a “time gate” device, where detection of the watermark opens a time interval within which a user is allowed to perform an action, such as pressing a button, typing in an answer, turning a key in a lock, etc.

Apparatus and system for transmitting and receiving optical code division multiple access data over an optical network. The apparatus comprises a spectral phase decoder for decoding the encoded optical signal to produce a decoded signal, a time gate for temporally extracting a user signal from the decoded signal, and a demodulator that is operable to extract user data from the user signal. The system preferably comprises a source for generating a sequence of optical pulses, each optical pulse comprising a plurality of spectral lines uniformly spaced in frequency so as to define a frequency bin, a data modulator associated with a subscriber and operable to modulate the sequence of pulses using subscriber data to produce a modulated data signals and a Hadamard encoder associated with the data modulator and operable to spectrally encode the modulated data signal to produce an encoded data signal.

SAL designation uses absolute time coding of the pulse-stream to disambiguate the designator in a manner that reduces the number of pulses in a pulse-stream and reduces the total pulse energy on the target. This requires timing synchronization between the designator and receiver. For improved rejection of unintended returns, more precise time gating (narrower absolute time window) is required. This can be achieved by removing the path length and or firing time uncertainty errors. Absolute time coding reduces the number of pulses and total energy on target in two ways. First, the designator may only have to transmit the pulse-code once. The “spot” appears for the brief time associated with a pulse-stream and disappears; continuous lasing of the target is not required. Second, the designator can be disambiguated using a combination of pulse-code (relative spacing of pulses) and pulse-position (absolute timing of pulses) modulation. This allows the pulse-stream to be shortened considerably, perhaps to a single pulse.

A memory cell unit and a recurrent neural network including memory cell units are provided. The memory cell unit includes a first time gate configured to control a cell state value of the memory cell unit, based on a phase signal of an oscillatory frequency, and a second time gate configured to control an output value of the memory cell unit, based on the phase signal.

An apparatus (10) for detecting a particle (12) labelled with a fluorescent marker is disclosed. The apparatus (10) has a flow cell (16) being adapted to contain a fluid (14) in which the particle (12) is suspended. A light source (28) is operatively coupled to the flow cell (16) and arranged for emitting a stimulating light (28) which is effective in optically exciting the fluorescent marker (12) for emitting a fluorescent light (30). The apparatus (10) also includes a spatial filter (50) across an optical path between the particle (12) and a time gated detector (32) operatively coupled to the flow cell (16) for detecting the fluorescent light (30).

Ultrasonic scan data is displayed within a display (10) and is arranged in a plurality of two and three-dimensional colored displays (20, 30, 40, 50). A C-scan display (40) is a composite plot of a region of interest using color to designate echo amplitude. The composite plot (40) is time-gated to limit the range of depths of data presented and thereby limit the plot to a tin section such as a surface. Surface breaking discontinuities (100) are visible as highly colored echoes within this C-scan display (40). Within C-scan display (40), once a discontinuity such as a reflector is detected, additional gates (150-165) may be set which permit other specialized displays such as D-scan (50) and B-scan (20) windows to portray the discontinuities. The D-scan plots index direction (54) against time (52), and readily displays circumferential reflectors (130-145) therein, while also enabling rapid estimation of the depth (142) of these reflectors. A B-scan plot (20) which enables fine profiling of reflectors may be a single pane taken at a single axial location determined by an index cursor (168), or may alternatively be a composite plot. Various modifications to the basic system are disclosed that further enhance the utility of the display (10).

An object of the present invention is to provide an OCDM transceiver with which the reduction amount of the intensity of the correlation waveform signal is smaller than that of a conventional device of the same type in the decoding step that comprises a time gate processing step. Hence, in the OCDM transceiver of the present invention that comprises an encoding portion and a decoding portion, the decoding portion is constituted comprising a decoder, clock extractor, and time gate. The decoder decodes an encoded optical pulse signal and separates the encoded optical pulse signal into a clock signal extraction signal and an optical pulse signal playback signal. The clock extractor extracts a clock signal from the clock signal extraction signal. Further, the time gate removes only the auto-correlation waveform component from the optical pulse signal playback signal. The auto-correlation waveform component is converted to an electrical signal by means of an optical receiver and generated as a reception signal.

The invention is directed to a remote 3-D imaging system which uses a novel illumination source to establish the relationship of the image features to the system, which is displayed by virtue of calculations. In addition to static surfaces, moving surfaces may be studied and corrections due to turbidity and platform position are also easily compensated for. The instant system may also contain a plurality of sensing systems based on light, including traditional reflective or elastic scattering and novel fluorescent or non-elastic scattering still and video imaging systems, including time-gated systems.

Systems and method for imaging through scattering media. One example of an imaging system includes an illuminator configured to produce a structured illumination pattern and to direct the structured illumination pattern into an imaging field through a scattering medium, a camera configured to receive reflections of the structured illumination pattern from an object in the imaging field and to provide corresponding image data, a master oscillator coupled to the illuminator and to the camera and configured to modulate the structured illumination pattern and to clock the camera so as to time gate the reflections of the structured illumination pattern and provide signal timing data, and a processor coupled to the camera and received to receive and process the image data and the signal timing data to produce an image of the object.

The invention provides a time grating angular displacement sensor which belongs to displacement precise measuring devices. The sensor comprises a frame which is used for winding a coil and composed of an outer circle matrix and an inner circle matrix; and slots are formed on the inner peripheral wall of the outer circle matrix and the outer peripheral wall of the inner circle matrix at equal intervals. The sensor is characterized in that the excitation coil is wound on the matrix, and the induction coil is wound on the other matrix; the induction coil and the excitation coil carry out the relative motion; the excitation coil is connected with an excitation power supply, an excitation signal and an electric signal which is output by the induction coil are respectively connected to an amplification circuit and subjected to the phase comparison by a digital phase comparator after the shaping by a shaping circuit; and the phase difference of the two signals is represented by the number of interpolated clock pulses, further converted to the angular displacement value and directly or indirectly displayed as the angular displacement data after the treatment by a microprocessor and a memory. The sensor has the advantages of simple structure, low cost, high resolution, strong anti-interference ability and easy productization.

An ultrasonic imaging system acquires echo signals from an object being imaged such as a moving coronary artery and the cross-correlation between echo signals is employed as an objective measure of relative object location. The method is used in a prescan procedure to determine an optimal gating window to acquire image data during a cardiac gated scan, and it is used during the scan as a real time gating signal.

A method and a measurement system determine a transmission response of a device under test (DUT). The method includes measuring a reflection response from a first port of the DUT while a known reflective termination is on a second port of the DUT, and time gating the measured reflection response to produce a gated reflection response that is the transmission response of the DUT. The measurement system includes a vector network analyzer, a controller, a memory and a computer program. The computer program includes instructions that implement measuring the reflection response from the first port of the DUT, and further implement time gating the measured reflection response. The time gating isolates reflection data associated with the known reflective termination from the measured reflection response.

Configuration of an ultrasonic inspection system is facilitated using an ultrasound response predicted by a simulation tool. In one embodiment, estimated material properties of an object to be inspected are input to the simulation tool. Also input to the simulation tool is at least one estimated property of an ultrasonic transducer of the ultrasonic inspection. The simulation tool predicts the response of the object to ultrasound from the ultrasonic transducer. This response is dependent upon the estimated material properties of the object to be inspected and the at least one estimated property of the ultrasonic transducer. The ultrasonic inspection system is then configured dependent upon a feature of the predicted response. The system may be configured, for example, by setting the position of a time gate, selecting an appropriate ultrasonic transducer, selecting the position of the transducer to achieve good focus, or selecting parameters for signal processing.

Apparatus and method for amplifying laser signals using segments of fibers of differing core diameters and / or differing cladding diameters to suppress amplified spontaneous emission and non-linear effects such as four-wave mixing (FWM), self-phase modulation, and stimulated Brillouin and / or Raman scattering (SBS / SRS). In some embodiments, different core sizes have different sideband spacings (spacing between the desired signal and wavelength-shifted lobes). Changing core sizes and providing phase mismatches prevent buildup of non-linear effects. Some embodiments further include a bandpass filter to remove signal other than the desired signal wavelength and / or a time gate to remove signal at times other than during the desired signal pulse. Some embodiments include photonic-crystal structures to define the core for the signal and / or the inner cladding for the pump. Some embodiments include an inner glass cladding to confine the signal in the core and an outer glass cladding to confine pump light in the inner cladding.

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

The invention discloses a spectrum analysis system which comprises a Czerny-Turner light path structure, a photomultiplier tube array, an optical fiber array, a multi-channel time gating counter, a high-voltage power supply and a temperature controlling module. The photomultiplier tube array includes N photomultiplier tubes, wherein N is a positive integer. The optical fiber array comprises N sets of optical fibers, and the first end of each set of optical fibers form a column in the direction parallel to an entrance slit and installed on the focusing plane of the Czerny-Turner light path structure, wherein the first end of each set of optical fibers collects monochromatic light of different wave lengths, and the second ends of the N sets of optical fibers are correspondingly connected with the N photomultiplier tubes in a one-to-one mode so that light signals of different wave lengths can be conducted to different photomultiplier tubes. The temperature controlling module is connected with the photomultiplier tube array and used for keeping the photomultiplier tube array in a constant low-temperature environment in the process of spectral measurement. The spectrum analysis system has the advantages of having high sensitivity and high time resolution and being capable of being used for collecting weak fast-changing non-redundant spectrum signals.

A pulsed coherent fiber array laser system that includes a beam generating sub-system that provides a signal pulse beam having pulses of the desired duration that is split into several fiber channels. Optical leakage between the pulses in each split beam is measured and locked to a reference beam by a phase sensing circuit and phase adjusters so that the phase of each fiber pulsed beam is aligned with the phase of the reference beam. A pulse clipper or filter is employed to remove the pulses in the fiber beams so that they do not saturate the phase sensing circuit. The beam generating sub-system can employ any suitable combination of devices to generate the signal beam and the reference beam, including continuous wave master oscillators, amplitude modulators, frequency shifters, injection seed oscillators, Q-switched lasers, reference oscillators, frequency lockers, wavelength division multiplexers, time gated switches, etc.

A security kiosk for controlling access to an area, includes a housing, a visitor identification reader, a data storage device, a controller, and a visitor interface device. The visitor identification reader is configured to read a visitor identifier and produce a visitor identification signal indicative of a visitor's identity. The data storage device is configured to store approved visitor data including approved visitors and corresponding date and time gate entry periods, and update the approved visitor data from a remote security database at periodic intervals. The controller is configured to generate an access signal as a function of comparing the visitor's identity with the approved visitor data, and transmit the access signal to a barrier actuation system. The visitor interface device is configured to produce and transmit a visitor signal inputted on a user interface.

A model-based approach to estimating wall positions for a building is developed and tested using simulated data. It borrows two techniques from geophysical inversion problems, layer stripping and stacking, and combines them with a model-based estimation algorithm that minimizes the mean-square error between the predicted signal and the data. The technique is designed to process multiple looks from an ultra wideband radar array. The processed signal is time-gated and each section processed to detect the presence of a wall and estimate its position, thickness, and material parameters. The floor plan of a building is determined by moving the array around the outside of the building. In this paper we describe how the stacking and layer stripping algorithms are combined and show the results from a simple numerical example of three parallel walls.

The invention discloses a super-resolution microscopic method of time-gated wide-field stimulated emission. The method comprises the steps as follows: 1), exciting light is projected to a to-be-tested sample by a microscope objective, and the to-be-tested sample is subjected to wide-field excitation to generate fluorescence; 2), depletion light is similarly projected to the to-be-tested sample after modulated by a beam modulation module, so that illumination light spots in a dark-spot array are formed, and stimulated emission depletion is performed in a wide-field excitation area; 3), fluorescence emitted by the to-be-tested sample after subjected to the stimulated emission depletion is collected by the microscope objective and focused and projected to a photoelectric sensor, so that a fluorescence image of the to-be-tested sample is obtained; 4), the to-be-tested sample is moved horizontally, step 1) to step3) are repeated, and horizontal two-dimensional scanning is performed on the to-be-tested sample to obtain fluorescence images corresponding to scanning positions; and 5), all fluorescence images are moved horizontally and superimposed to recover a two-dimensional super-resolution image finally. The invention further discloses a super-resolution microscopic device of the time-gated wide-field stimulated emission.

Portable, field-deployable laser synthesizer devices designed for multi-dimensional spectrometry and time-resolved and / or hyperspectral imaging include a coherent light source which simultaneously produces a very broad, energetic, discrete spectrum spanning through or within the ultraviolet, visible, and near infrared wavelengths. The light output is spectrally resolved and each wavelength is delayed with respect to each other. A probe enables light delivery to a target. For multidimensional spectroscopy applications, the probe can collect the resulting emission and deliver this radiation to a time gated spectrometer for temporal and spectral analysis.