A method and system for evaluating the reliability of toxicological data

A technology of reliability and toxicology, applied in the field of evaluation methods and systems for the reliability of toxicological data, can solve the problems of lack of quantitative and practical evaluation tools, and achieve the effect of good external authenticity

Active Publication Date: 2022-04-19
JIANGSU PROVINCIAL CENT FOR DISEASE PREVENTION & CONTROL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of quantitative and practical evaluation tools for the reliability evaluation of toxicological data

Method used

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  • A method and system for evaluating the reliability of toxicological data
  • A method and system for evaluating the reliability of toxicological data
  • A method and system for evaluating the reliability of toxicological data

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] For animal test data, a rapid evaluation channel has been established. After the evaluation indicators of the rapid evaluation channel are met and confirmed by further verification, it can be directly evaluated as a high reliability level, otherwise specific index evaluation is required.

[0037] For the data that has not passed the rapid evaluation channel, the reliability evaluation is carried out from five parts: test substance, experimental animal, experimental design, experimental operation and method, experimental result and conclusion. It includes 22 specific evaluation indicators. Comparing with the scoring elements and suggested scores listed in the evaluation indicators, score items one by one according to whether the scoring elements are satisfied, multiply by the weight corresponding to each evaluation indicator, and calculate the percentage (actual score / total score ), the reliability of the data is divided into three levels of high, medium and low reliabili...

Embodiment 2

[0074] For in vitro test data, a rapid evaluation channel has been established. After the evaluation indicators of the rapid evaluation channel are met and confirmed by further verification, it can be directly evaluated as a high reliability level, otherwise specific index evaluation is required.

[0075] For data that has not passed the rapid evaluation channel, the reliability evaluation is carried out from five parts: test substance, test system, test design, test operation and method, test result and conclusion. It includes 15 specific evaluation indicators. Comparing with the scoring elements and suggested scores listed in the evaluation indicators, score each item according to whether the scoring elements are satisfied, multiply by the weight corresponding to each evaluation indicator, and calculate the percentage. Percentage = actual score / The total score divides the reliability of the data into three levels of high, medium and low reliability according to the percenta...

Embodiment 3

[0095] For human data, the reliability evaluation is carried out from five parts: research type and research object, measurement, quality control, bias control, results and conclusion. It includes 12 specific evaluation indicators. Comparing with the scoring elements and suggested scores listed in the evaluation indicators, according to whether the scoring elements are satisfied or not, the scores are scored one by one, multiplied by the weight corresponding to each evaluation indicator, and the percentage is calculated. Percentage = actual score / The total score divides the reliability of the data into three levels of high, medium and low reliability according to the percentage.

[0096] For example, for a human data.

[0097] First, enter the basic information such as the name, title, and work unit of the evaluator; and enter the basic information such as the author's name, title, publication year, and author's institution for the toxicological data.

[0098] Scores are ma...

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PUM

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Abstract

The invention discloses a method and system for evaluating the reliability of toxicological data. For the animal test data, the reliability evaluation is carried out from five parts: the test substance, experimental animals, test design, test operation and method, test results and conclusions. For in vitro test data, reliability evaluation is carried out from five parts: test substance, test system, test design, test operation and method, test result and conclusion. For human data, the reliability evaluation is carried out from five parts: research type and research object, measurement, quality control, bias control, results and conclusion. Aiming at the gap in the prior art, the invention designs a set of detailed and quantitative evaluation method and system for reliability evaluation of toxicological data.

Description

technical field [0001] The invention belongs to the technical field of data information processing, and in particular relates to an evaluation method and system for the reliability of toxicological data. Background technique [0002] In addition to obtaining data from toxicological tests, toxicological safety evaluation requires the use of a large number of reported toxicological data to illustrate the toxicity and potential hazards of a specific substance, identify hazards, and predict the degree of safety after human exposure. At the same time, the risk assessment of existing hazards that may cause adverse effects on human health also requires reliable and high-quality toxicological data (data, reports, etc.) important role in this link. [0003] At present, the evaluation of the reliability of toxicological data is mainly based on the experience value and subjective judgment of the evaluators, which may result in completely different evaluation conclusions for the same d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16C20/00G06Q10/06
CPCG06Q10/0639G16C99/00
Inventor 卞倩刘兆平吴俊俞萍宋雁吕中明朱宝立
Owner JIANGSU PROVINCIAL CENT FOR DISEASE PREVENTION & CONTROL
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