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Application of acellular allogeneic dermal matrix in penile augmentation

A dermal matrix and decellularization technology, applied in the field of tissue engineering of biomedical materials, can solve the problems of undetected specific effects, different effects, complicated operations, etc., achieve stable scaffold or template effect, improve mechanical properties, and in vivo phase good capacitive effect

Active Publication Date: 2018-08-07
BEIJING JAYYALIFE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the middle of the 1980s, autologous fat injections began to be used to thicken the penis, but due to the different fat preparations, injection methods and injection volumes, the effects are also different, so the controversy is relatively large
However, these materials are generally expensive except for silicone rubber prostheses, and some methods are more complicated to operate
Although these techniques are occasionally reported, the specific effects have not yet been found in statistics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation method of acellular allodermal matrix

[0047] Put allogeneic leather raw materials into 0.3g / L phospholipase and 0.1g / L trypsin solution, the pH value of the enzyme solution is 7.0, the temperature is 37°C, shake at 100rpm for 2 hours, replace the enzyme solution once, repeat this process once, The semi-finished product A is obtained; the phospholipase is a mixture of phospholipase A1: phospholipase A2: phospholipase C: phospholipase D according to the mass ratio of 1:1:1:1.

[0048] The semi-finished product A was taken out, put into a container filled with physiological saline solution, soaked in physiological saline, oscillated 3 times, each time for 2 hours, the oscillation speed was 80 rpm, and the temperature was 2°C to obtain the semi-finished product B.

[0049] Put the semi-finished product B into the solution containing 0.2g / LTritonX-100, 50KHz, 220W, ultrasonic for 5 minutes, soak for 3 hours, repeat this process 3 times, and get the se...

Embodiment 2

[0055] Example 2 Preparation method of acellular allogeneic dermal matrix

[0056] Put allogeneic leather raw materials into 0.2g / L phospholipase and 0.2g / L trypsin solution, the pH value of the enzyme solution is 7.0, the temperature is 37°C, shake at 100rpm for 2 hours, replace the enzyme solution once, repeat this process once, The semi-finished product A is obtained; the phospholipase is a mixture of phospholipase A1, phospholipase A2, phospholipase C and phospholipase D according to the mass ratio of 1:1:1:1.

[0057] The semi-finished product A was taken out, put into a container filled with physiological saline solution, soaked in physiological saline, oscillated 3 times, each time for 2 hours, the oscillation speed was 80 rpm, and the temperature was 2°C to obtain the semi-finished product B.

[0058] Put the semi-finished product B into a solution containing 0.2g / LSDS, 10mM EDTA, 50KHz, 220W, ultrasonic for 7 minutes, soak for 2 hours, repeat this process 3 times, and...

experiment example 1

[0066] Experimental example 1 Acellular allogeneic dermal matrix (built-in biological sleeve) used in penis enlargement surgery

[0067] Surgical method: make a circular incision about 1 cm away from the coronal sulcus, incise the superficial fascia and deep fascia to the surface of the albuginea, dissociate downward along the surface of the albuginea to the root of the penis, and ungaze the penis. The acellular allogeneic dermal matrix was prepared as required into a built-in biological sleeve, sutured and fixed on the tunica albuginea, the distal end was under the coronal sulcus, and both sides were to the sulcus between the corpus cavernosum and the urethral corpus cavernosum, the incision was sutured layer by layer, and the penis was moderately pressurized and bandaged .

[0068] Postoperative treatment:

[0069] 1. The penis is moderately pressurized and bandaged for 1-3 weeks after the operation.

[0070] 2. Pay attention to the edema of the foreskin after the operatio...

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Abstract

The invention relates to application of an acellular allogeneic dermal matrix in penile augmentation. In order to adapt to the penile augmentation and provide an appropriate built-in biological sleevematerial, the novel acellular allogeneic dermal matrix material is prepared by the coordination of multiple steps such as enzyme treatment, surfactant ultrasonic treatment and DNA degradation treatment and prepared into the built-in biological sleeve which is used for treating premature ejaculation and small and short penis. The acellular allogeneic dermal matrix or built-in biological sleeve isused for penile augmentation or lengthening or dorsal nerve isolation surgery while dorsal nerve cutting is not needed, and psychogenic erectile dysfunction caused by the fact that a patient worries about the dorsal nerve cutting is avoided.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering of biomedical materials, in particular to an acellular allogeneic dermal matrix and its application in penis thickening. Background technique [0002] In the past, there were many methods for penis enlargement, but they were mainly aimed at patients with small penises. It was not until the 1990s that penis enlargement was used for cosmetic plastic surgery of normal penis. At present, penis enlargement surgery is usually used for congenital or idiopathic penile dysplasia and small penis, or the quality of sexual life is not high because of the loose vagina after the wife gave birth, or is not satisfied with the thickness of the own penis. Penis enlargement surgery in order to improve the quality of sexual life. [0003] The popular injection of liquid silicone used to thicken the penis decades ago has been banned because liquid silicone is prone to rejection, formation of nodules, abnor...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/362A61L27/3633A61L27/3687A61L27/3691A61L27/50A61L2430/34A61L2430/40
Inventor 孙继煌王海曾昂白明张海林吴元翼张晓威王伟李雪银刘文进李卫强石清东
Owner BEIJING JAYYALIFE BIOTECH CO LTD
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