Method for determining palladium metal residues in dezocine raw materials

A metal residue and determination method technology, applied in the field of chemical detection, can solve the problems of low safety and long time consumption, and achieve the effect of saving time
CN108444984AInactive Publication Date: 2018-08-24南京明捷生物医药检测有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
南京明捷生物医药检测有限公司
Publication Date
2018-08-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for determining palladium metal residues in dezocine raw materials and specifically relates to the field of chemical detection. According to the method, the content ofpalladium in the dezocine raw materials is controlled, a sample is directly dissolved with an acetonitrile water liquor with proper concentration, a liquor is diluted with 2% HNO3 to required concentration, and the content of palladium elements is determined with a one-point external standard method by use of an ICP-MS (inductively coupled plasma source mass spectrometer). Compared with microwavedigestion or graphite digestion, the treatment method is safer and time-saving.
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Description

technical field

[0001] The invention belongs to the field of chemical detection, and in particular relates to a method for determining palladium metal residues in dezocine raw materials. Background technique

[0002] In recent years, domestic and foreign restrictions on heavy metals in various synthetic drugs, animal and plant extracts, nutritional products and food have become increasingly stringent, and the export of related domestic industries is facing huge challenges. Synthetic pharmaceuticals also face the same problem. Metal catalysts are often used in the synthesis process of pharmaceutical raw materials, and countries also have strict requirements on the limits of metal reagent residues. The United States Pharmacopoeia USP has also made major revisions to the heavy metal testing of pharmaceuticals, and regulations have become more stringent.

[0003] Dezocine is a drug for relieving postoperative pain, muscular tissue and organ and cancer analgesia; it has the char...

Claims

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