Aorticorenal ganglion detection

A kidney and catheter technology, applied in the field of catheter components, devices for the treatment of hypertension and related conditions, can solve problems such as limited

Inactive Publication Date: 2018-08-31
HALCYON MEDICAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Renal nerve denervation based on percutaneous hyperthermia devices can achieve such goals, but are limited to appropriate renal vascular anatomy

Method used

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  • Aorticorenal ganglion detection
  • Aorticorenal ganglion detection
  • Aorticorenal ganglion detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0167] consider Figure 22 As a schematic diagram of the setup to implement method 1 using unipolar selection. As previously discussed, the device may be configured to connect any electrode on the catheter distal assembly to the terminals (153 and 154) of the stimulation generator 63 . In this example, specific electrodes on the catheter distal assembly will be connected to terminals 153 . Throughout the described procedure, terminal 154 is connected to the dispersion pad. For this discussion, sensor element 58 measures blood flow velocity and is connected to monitoring unit 66 . The catheter distal assembly is positioned such that electrodes 42 - 49 are in good electrical contact with the upper side wall of renal artery 59 .

[0168] The following is an example of a search algorithm for searching for a target location. For a flowchart of the algorithm, see Figure 38 . It begins by stimulating the catheter electrode closest to the ostium, ie, electrode 42, and then sele...

Embodiment approach 2

[0195] consider Figure 23 and Figure 24 As a schematic diagram of the apparatus used to implement method 2.

[0196] Measuring the RSNA at a location is done by selecting two electrodes adjacent to that location. If no significant RSNA is measured, there is no nerve within range of the receiver. Such as image 3 As shown, the ARG13 postganglionic nerve begins to innervate the renal artery just below the ARG. The segment of the superior renal artery between the target site and the ostium has little or no innervation; therefore, electrodes adjacent to this segment will detect little or no RSNA. Electrodes farther from the target location will detect RSNA, but as the nerve branches progressively toward the kidney, the amplitude decreases due to the dispersion of nerve activity. The example search algorithm shown below (for a flowchart of the algorithm, see Figure 40 ) to measure the RSNA of the two groups of electrodes located on the upper side to detect significant chan...

specific example

[0303] Renal artery spasm can be induced by applying mechanical pressure on the renal artery wall using a probe. Reduced responsiveness of the renal arteries to intravascular mechanical stimuli is a sign that renal afferents and / or ARGs have been damaged and are unable to transmit receptor signals to the CNS.

[0304] By applying electrical stimulation to afferent nerves surrounding the renal arteries, researchers (P. Gal et al., Journal of Hypertension 2014: 1-4) have reported changes in systemic blood pressure and / or heart rate. Reduced responsiveness of systemic blood pressure and / or heart rate to intravascular electrical stimulation along the renal arteries is a sign that renal afferents and / or ARGs have been damaged and are unable to transmit receptor signals to the CNS.

[0305] Depending on the nature of the stimulating signal (ie, pulse shape, pulse amplitude, pulse frequency, pulse duty cycle, monophasic versus biphasic), intravascular electrical stimulation of the AR...

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Abstract

Devices and methods that regulate the innervation of the kidney by detection and modification of the aorticorenal ganglion. Devices for percutaneous detection and treatment of the aorticorenal ganglion via a blood vessel to modify renal sympathetic activity.

Description

[0001] related application [0002] This application claims priority to US Provisional Application No. 62 / 237,966, entitled Aortorenal Ganglion Detection, filed October 6, 2015, the entire contents of which are incorporated herein by reference. Background technique [0003] Hypertension, or abnormally high blood pressure, is a growing public health problem for which successful treatment is often elusive. 67 million Americans—about one-third of the adult population—have high blood pressure, and these numbers are increasing as the population ages and obesity rises. [0004] High blood pressure is more common in men than women, and affects about 50 percent of people over the age of 65. High blood pressure is serious because people with the condition are at higher risk for heart disease and other medical problems than people with normal blood pressure. If left untreated, high blood pressure can lead to hardening of the arteries, heart attack, stroke, enlarged heart, and kidney d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/00A61N1/05A61N1/36
CPCA61B5/40A61B5/6852A61B5/6886A61B18/1492A61B18/1815A61B18/24A61B2018/0016A61B2018/00214A61B2018/00267A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00577A61B2018/00702A61B2018/00791A61B2018/00839A61B2018/00875A61B2018/1425A61B2018/1435A61N1/0551A61N1/0558A61N1/36007A61N1/36017A61N7/02A61N2007/003A61B18/1206A61B2018/0022A61B2018/00589A61B2018/1253A61B2018/126A61B2018/143
Inventor 道格拉斯·克里斯多夫·哈林顿马克·托马斯威廉·大卫·霍尔特
Owner HALCYON MEDICAL INC
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