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Application of soybean peptide to preparing heart protection drugs

A cardioprotective, soybean peptide technology, applied in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve the problem that soybean peptides are not reported

Inactive Publication Date: 2018-09-18
河南省南街村(集团)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Soybean peptide (soybean peptide, SP), also known as soybean protein hydrolyzed peptide, contains 8 kinds of essential amino acid components required by the human body. 500Da to 3000Da, it has the effects of regulating immunity, promoting muscle growth, anti-tumor, and lowering blood lipids, but there is no report on whether soybean peptide has other effects

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  • Application of soybean peptide to preparing heart protection drugs
  • Application of soybean peptide to preparing heart protection drugs
  • Application of soybean peptide to preparing heart protection drugs

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with some specific examples.

[0023] 1 Materials and methods

[0024] 1.1 Main reagents

[0025] Soybean peptide, superoxide dismutase (SOD), malondialdehyde (Malondialdehyde, MDA), glutathione peroxidase (GSH-Px), catalase (CAT), Lactate dehydrogenase (Lactate dehydrogenase, LDH), creatine kinase (Creatinekinase, CK) and creatine kinase MB isoenzyme (CK-MB) detection kit; NF-κB, IKK-β, IκB- α, LC3, Beclin-1, Atg7 and β-actin antibodies; RIPA lysate, BCA protein concentration determination kit, SDS-PAGE gel preparation kit, BeyoColor TM Color pre-stained protein molecular weight standard (10-170KDa), HRP-labeled goat anti-rabbit IgG secondary antibody, BeyoECL Plus ultra-sensitive ECL chemiluminescence kit, BeyoRT TM II M-MLV Reverse Transcriptase, BeyoRT TM II cDNA First Strand Synthesis Kit and Trizol Total RNA Extraction Reagent;

[0026] 1.2 Animals and grouping

[0027] SPF grade healthy ma...

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Abstract

The invention discloses application of soybean peptide to preparing heat protection drugs. The invention discovers that soybean peptide can obviously enhance the SOD, GSH-Px and CAT activity in serumof an exhaustive exercise mice, reduce the content of MDA, LDH, CK and CK-MB, decrease the cardiac muscle tissue NF-kappaB, IKK-beta mRNA and protein expression level, and increase IkappaB-alpha mRNAand protein expression level, so that soybean peptide has the relatively good protection effect on the exhaustive exercise heart, soybean peptide protecting the heart of the exhaustive exercise mice is related to anti-oxidative stress and inhibition of NF-kappaB signal route, soybean peptide improving the cardiac function of the exhaustive exercise mice and the hemodynamic mechanism action is related to inhibition of cell autophagy, and so that soybean peptide can serve as a potential heart protection drug.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the use of a soybean peptide in the preparation of cardioprotective medicine. Background technique [0002] Soybean peptide (soybean peptide, SP), also known as soybean protein hydrolyzed peptide, contains 8 kinds of essential amino acid components required by the human body. 500Da to 3000Da, it has the effects of regulating immunity, promoting muscle growth, anti-tumor, and lowering blood lipids, but there is no report on whether soybean peptide has other effects. [0003] Exhaustive exercise (EE) refers to the continuous overloading of the body on the basis of fatigue until exhaustion and no longer activities. It is a kind of super-intensity and overloading exercise. Exhaustive exercise is a kind of excessive exercise, the body's demand for blood, oxygen and energy increases sharply, and the products of anaerobic glycolysis and free radicals continue to increase, which...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61P9/00A61P43/00A61P9/10A61P39/06
CPCA61K38/011A61P9/00A61P9/10A61P39/06A61P43/00
Inventor 徐松涛金少举马永超李盘欣黄亚男李丹阳史咏华王培英彭丽李晓玲
Owner 河南省南街村(集团)有限公司
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