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Application of crocetin or derivative thereof in preparing medicine for treating heart failure

A technology of crocus acid and derivatives, applied in the field of biomedicine, can solve problems such as the effect of crocus acid that has not been studied yet

Inactive Publication Date: 2018-09-21
杏林中医药科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that crocetin is a natural pigment and antioxidant, which can be used as a skin singlet oxygen scavenger, a collagen synthesis stimulator and a skin immune booster, and has multiple biological functions, but so far, no research has clarified The role of crocetin in the treatment of heart failure

Method used

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  • Application of crocetin or derivative thereof in preparing medicine for treating heart failure
  • Application of crocetin or derivative thereof in preparing medicine for treating heart failure
  • Application of crocetin or derivative thereof in preparing medicine for treating heart failure

Examples

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Effect test

Embodiment 1

[0058] An embodiment of the medicine for treating heart failure according to the present invention, the medicine is a tablet, and every 1000 tablets comprises the following components: 20 g of crocetin shown in formula (II), 150 g of microcrystalline cellulose, carboxymethyl Appropriate amount of sodium starch 6g, magnesium stearate 2g and 70% medicinal ethanol.

[0059] The preparation method of described medicine is: above-mentioned raw material is passed through 100 mesh sieves respectively, takes by weighing crocetin, carboxymethyl starch sodium, microcrystalline cellulose shown in the formula (II) after sieving according to above-mentioned recipe quantity, mixes Evenly, use 70% medicinal ethanol to make a soft material, pass through a 20-mesh sieve to make wet granules, dry at 55°C for 4 hours, granulate with a 24-mesh sieve, add magnesium stearate, mix evenly, and press into tablets. 940 tablets were prepared.

Embodiment 2

[0061] An embodiment of the drug for treating heart failure according to the present invention, the drug is a tablet, and every 1000 tablets contains the following components: 50 g of crocetin derivatives shown in formula (III), 40 g of microcrystalline cellulose, hydroxyl Promellose 70g, magnesium stearate 5g and 70% medicinal ethanol in right amount.

[0062] The preparation method of the medicine is as follows: the above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve, and the crocetin derivatives, microcrystalline cellulose and hypromellose shown in the sieved formula (III) are weighed according to the above-mentioned prescription quantity. , mix evenly, use 70% medicinal ethanol to make a soft material, pass through a 20-mesh sieve to make wet granules, dry at 55°C for 4 hours, granulate with a 24-mesh sieve, add magnesium stearate, mix evenly, and press into tablets , a total of 945 tablets were prepared.

Embodiment 3

[0064] An embodiment of the medicine for treating heart failure according to the present invention, the medicine is a capsule, and every 1000 capsules contains the following components: 5 g of crocetin shown in formula (II), 100 g of microcrystalline cellulose, carboxymethyl 5g of sodium starch, 1g of magnesium stearate and 70% medicinal ethanol in an appropriate amount.

[0065] The preparation method of described medicine is: above-mentioned raw material is passed through 100 mesh sieves respectively, takes by weighing crocetin, carboxymethyl starch sodium, microcrystalline cellulose shown in the formula (II) after sieving according to above-mentioned recipe quantity, mixes Evenly, use 70% medicinal ethanol to make a soft material, pass through a 20-mesh sieve to make wet granules, dry at 55°C for 4 hours, granulate with a 24-mesh sieve, add magnesium stearate to mix evenly, fill capsules, and 932 capsules were prepared.

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Abstract

The invention discloses application of crocetin or a derivative thereof in preparing a medicine for treating heart failure. The crocetin or the derivative thereof has a structural formula (I) as shownin the specification. The inventor of the invention finds that for a first time the crocetin or the derivative is capable of remarkably improving cardiac functions of ventriculus sinister of a rat suffering from chronic heart failure caused by coronary artery ligation, inhibiting secretion of angiotensin II, a neuroendocrine factor NT-ProBNP and a heart failure regulatory factor IL-6 in a rennin-angiotensin-aldosterone system (RAAS) which is over-activated in the heart failure process, and inhibiting myocardium pathology reconstitution, and in addition, effects of a part of indexes are betterthan those of astragalus membranaceus-draba nemorosa heart strengthening capsules.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of crocetin or its derivatives in the preparation of medicines for treating heart failure. Background technique [0002] Heart failure, referred to as heart failure (HF), also known as cardiac insufficiency, is due to myocardial damage induced by various etiologies, causing cardiac systolic and / or diastolic dysfunction, unable to fully discharge the venous blood return to the heart, and cardiac output Absolute or relative reduction, leading to blood stasis in the venous system, insufficient blood perfusion in the arterial system, and a syndrome of cardiac circulation disorders. Clinically, pulmonary circulation and (or) systemic circulation congestion and tissue blood perfusion are the main features; the overall prognosis of the disease is poor, It is a clinical critical symptom, the final destination and main cause of death of various cardiovascular disea...

Claims

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Application Information

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IPC IPC(8): A61K31/557A61K31/7024A61P9/04C07C57/13C07H13/06
CPCA61K31/557A61K31/7024A61P9/04C07C57/13C07H13/06
Inventor 马仁强王廷春周清杜铁良王宁丁徐鸿方哲
Owner 杏林中医药科技(广州)有限公司
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