A pharmaceutical composition for preventing and treating diabetic neuropathy

A technology for neuropathy and a composition, which is applied in the field of drugs for the prevention and treatment of chronic complications of diabetes, can solve problems such as unsatisfactory prevention and treatment effects of diabetic neuropathy, and achieve the effects of significant synergistic antagonism of toxicity, good prevention and treatment, and obvious effects.

Active Publication Date: 2021-01-05
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a pharmaceutical composition for preventing and treating diabetic neuropathy, so as to solve the technical problem of unsatisfactory prevention and treatment effect of existing diabetic neuropathy

Method used

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  • A pharmaceutical composition for preventing and treating diabetic neuropathy
  • A pharmaceutical composition for preventing and treating diabetic neuropathy
  • A pharmaceutical composition for preventing and treating diabetic neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Zanthoxylum bungeanum extract: Take Zanthoxylum bungeanum, crush it into coarse powder, add 4 times the amount of 95% ethanol, heat and reflux extraction for 3 times, each time for 1 hour, combine the extracts, filter, and recover the solvent under reduced pressure at 50°C until there is no alcohol smell, 50°C After drying under reduced pressure for 24 hours, the Zanthoxylum bungeanum extract was obtained as a brown oil with a yield of 26.4% (g / g).

Embodiment 2

[0029] Preparation of rattan pepper extract: rattan pepper, directly squeezed rattan pepper oil with a press machine, filtered and separated for equipment, it is a yellow-brown oily substance with a yield of 8.3% (g / g).

Embodiment 3

[0031] Preparation of capsicum extract: crush capsicum into coarse powder, add 4 times the amount of vegetable oil, heat and reflux for extraction 3 times, 1 hour each time, combine the extracts, filter, and set aside, it is a reddish-brown oily substance.

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating diabetic neuropathy, and relates to the field of preventing and treating pharmaceuticals for chronic complication of diabetes mellitus. The pharmaceutical composition is prepared by using Sichuan pepper or zanthoxylum armatum fruits, fructus capsici and rhizoma chuanxiong or an extract thereof as raw materials, and formed in the following compatibility proportion in parts by weight: 0.5-5.0 parts of the Sichuan pepper or the zanthoxylum armatum fruits, 0.01-0.1 parts of the fructus capsici, and 5.0-50.0 parts of the rhizoma chuanxiong. The pharmaceutical composition has the apparent synergistic interaction effect while the three parties of the Sichuan pepper or the zanthoxylum armatum fruits, the fructus capsici and the rhizoma chuanxiong are combined, and has the remarkable synergistic antagonistic toxicity effect at the same time, so the composition has the good preventing and treating effect to the diabetic neuropathy finally.

Description

technical field [0001] The invention relates to the field of drugs for preventing and treating chronic complications of diabetes, in particular to a pharmaceutical composition for preventing and treating diabetic neuropathy. Background technique [0002] According to the survey, the incidence of diabetes among the current urban population in my country has reached about 10%. According to this calculation, the existing population of diabetes in my country has reached about 130 million. Due to the widespread use of hypoglycemic drugs, the damage of diabetes itself to the human body has been reduced to a very low level. However, many chronic complications of diabetes, especially diabetic neuropathy, have seriously affected the quality of life and life expectancy of diabetic patients. According to reports, diabetes The incidence of neuropathy accounts for more than 70%. [0003] Diabetic neurological complications are diseases involving the entire nervous system, including diab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61P3/10A61P25/00A61P17/02
CPCA61K9/0014A61K36/236A61K36/758A61K36/81A61P3/10A61P17/02A61P25/00A61K2300/00
Inventor 谭正怀张爱军苟文伊唐大轩熊静悦陈园园张秀刘琪张莉
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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