A kind of preparation method of SERS chip

A chip, pit technology

Active Publication Date: 2022-04-12
苏州英菲尼纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is cumbersome to transfer the template and wash with hydrochloric acid, and it is difficult to transfer AAO to other substrates to achieve large-scale preparation, and the cost is high

Method used

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  • A kind of preparation method of SERS chip
  • A kind of preparation method of SERS chip
  • A kind of preparation method of SERS chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of nano-sol:

[0062] Add 1mL of 1% silver nitrate aqueous solution into a 100mL three-necked flask and dilute to 100ml; heat the solution to boiling, and add 1% sodium citrate solution under constant reflux and vigorous stirring. The solution gradually changed from colorless to light blue. Start timing after discoloration, keep the system in a boiling state for 15 minutes under stirring, and then naturally cool to room temperature to obtain silver sol.

Embodiment 2

[0064] Preparation of nano-sol:

[0065] In a 100mL three-necked flask, add 1mL of an aqueous solution with a mass concentration of 1% silver nitrate and chloroauric acid (feeding molar ratio is 1:4) and dilute to 100ml; heat the solution to boiling, and add the concentration under continuous reflux and vigorous stirring. 1% sodium citrate solution. The solution gradually turned from light yellow to wine red. Start timing after discoloration, keep the system in a boiling state for 15 minutes under agitation, and then naturally cool to room temperature to obtain a gold-silver alloy sol.

Embodiment 3

[0067] Preparation of nano-sol:

[0068] In a 100mL three-necked flask, add 1mL of 1% chloroauric acid aqueous solution and dilute to 100ml; heat the solution to boiling, and add 1% sodium citrate solution under continuous reflux and vigorous stirring. The solution gradually turned from light yellow to wine red. Start timing after discoloration, keep the system in a boiling state for 15 minutes under stirring conditions, and then naturally cool to room temperature to obtain gold sol.

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Abstract

The invention provides a method for preparing a SERS chip, which includes the following steps of forming a plurality of disorderly distributed first conductive materials on a substrate by a self-assembly method; growing in situ on the surface of the first conductive materials second conductive material. The present invention assembles nanoparticles with small particle size disorderly on the substrate, and then grows the same or different elements at the position of the originally assembled nanoparticles through the method of in-situ growth. By controlling the secondary growth elements or growth dosage, it can A stable SERS chip with orderly and controllable morphology, high repeatability, uniform hot spots, stable properties, large-area growth, and high sensitivity is obtained. The chip has a simple preparation process, high efficiency, low cost, and can be used on a large scale The production of high-performance SERS chips can well meet the needs of commercialization. The SERS chip prepared by the invention can realize the detection of various low-concentration organic substances.

Description

technical field [0001] The invention relates to Surface-Enhanced Raman Scattering (SERS) technology, in particular to a method for preparing a SERS chip. Background technique [0002] In 1974, Fleischmann and others obtained high-quality Raman spectra of pyridine molecules on the surface of rough silver electrodes, which laid the foundation for the application of Raman spectroscopy to surface science research. Van Duyne et al found through detailed experiments and theoretical calculations that the Raman scattering signal of pyridine adsorbed on the rough silver surface is about 6 orders of magnitude stronger than that of the same amount of pyridine in the solution phase, and this The surface enhancement effect is called the SERS effect. SERS is like a magnifying glass, which magnifies trace information to the limit and presents it to people. Therefore, as an important research tool of surface and interface, SERS has great application prospects in the fields of materials sc...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor孙海龙郭清华
Owner苏州英菲尼纳米科技有限公司