Application of composition of folium cortex eucommiae and broadleaf holly leaf to preparation of medicament for preventing and treating diabetes and complications thereof

A technology of Kuding tea and Eucommia ulmoides leaves, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as the inability to clearly define the leading role in regulating blood sugar.

Inactive Publication Date: 2018-10-12
GUIZHOU MAQIKA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, 200910186104.5 health preparation containing Gastrodia elmoides ulmoides leaves and Kudingcha is made of Gastrodia elata, Eucommia leaves, and kudingcha as the main components, which discloses the effect of lowering blood pressure and blood fat; 201410289120.8 A kind of regulating blood fat and blood pressure , blood sugar Chinese medicine composition and its preparation method, although it has the effect of regulating the three highs, but the ingredients include gynostemma, cassia seed, hawthorn, kudingcha and other 15 ingredients, it is not very clear which medicinal material is responsible for regulating blood sugar to the leading role; and our company's previous research mainly focused on product process optimization, quality testing or compatibility, such as 201310270311.5 A health tea for lowering blood pressure and blood fat and its preparation method consists of 10-15 parts of Eucommia leaves, Kuding 30-50 parts of tea and 20-30 parts of Pu'er tea are made of raw materials, focusing on compatibility research, while 201310268359.2 A method of making teabags for lowering blood pressure and blood lipids focuses on the improvement of Eucommia double-lowering bagging agent technology optimization

Method used

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  • Application of composition of folium cortex eucommiae and broadleaf holly leaf to preparation of medicament for preventing and treating diabetes and complications thereof
  • Application of composition of folium cortex eucommiae and broadleaf holly leaf to preparation of medicament for preventing and treating diabetes and complications thereof
  • Application of composition of folium cortex eucommiae and broadleaf holly leaf to preparation of medicament for preventing and treating diabetes and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Eucommia leaves 500g, Kudingcha 400g

[0074] Kudingcha is dried under reduced pressure, crushed into a fine powder passing through a 40-mesh sieve, take 70% of the total amount, add 10 times the amount of water to decoct and extract 3 times, each time for 1 hour, combine the extracts, filter and concentrate to relative density The clear paste with a temperature of 1.15 at 80°C was subjected to microwave vacuum drying, and pulverized into fine powder to obtain Kudingcha extract;

[0075] Eucommia leaves were decocted and extracted 3 times with 10 times the amount of water, 1 hour each time, combined the extracts, filtered and concentrated to a clear paste with a relative density of 1.10 at 60°C, added ethanol to make the alcohol content reach 75%, and stirred evenly. Stand still for 12 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a clear paste with a relative density of 1.15 at 80°C, dry it in a microwave vacuum...

Embodiment 2

[0078] Eucommia leaves 1000g, Kudingcha 150g

[0079] Kudingcha is dried under reduced pressure, crushed into fine powder passing through a 60-mesh sieve, take 60% of the total amount, add 8 times the amount of water to decoct and extract twice, each time for 2 hours, combine the extracts, filter and concentrate to relative density The clear paste with a temperature of 1.20 at 70°C was subjected to microwave vacuum drying, and pulverized into fine powder to obtain Kudingcha extract;

[0080] Eucommia leaves were decocted with 8 times the amount of water and extracted twice, each time for 2 hours. The extracts were combined, filtered and concentrated to a clear paste with a relative density of 1.20 at 50°C. Add ethanol to make the alcohol content reach 65%, and stir evenly. Stand still for 12 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a clear paste with a relative density of 1.20 at 70°C, carry out microwave vacuum dr...

Embodiment 3

[0083] Eucommia leaves 700g, Kudingcha 300g

[0084] Kudingcha is dried under reduced pressure, crushed into a fine powder passing through a 60-mesh sieve, take 70% of the total amount, add 8 times the amount of water to decoct and extract twice, each time for 1.5 hours, combine the extracts, filter and concentrate to relative density The clear paste with a temperature of 1.20 at 80°C was subjected to microwave vacuum drying, and pulverized into fine powder to obtain Kudingcha extract;

[0085] Eucommia ulmoides leaves were decocted and extracted twice with 8 times the amount of water, each time for 1.5 hours. The extracts were combined, filtered and concentrated to a clear paste with a relative density of 1.20 at 60°C. Add ethanol to make the alcohol content reach 70%, and stir evenly. Stand still for 12 hours, filter with suction, recover ethanol from the filtrate under reduced pressure and concentrate to a clear paste with a relative density of 1.20 at 80°C, dry it in a mic...

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Abstract

The invention discloses application of a composition of folium cortex eucommiae and broadleaf holly leaf to preparation of a medicament for preventing and treating diabetes and complications thereof.The composition is prepared from extracts of the folium cortex eucommiae and the broadleaf holly leaf. The invention provides novel medicinal application of the composition containing the folium cortex eucommiae and the broadleaf holly leaf, thereby providing a new medicine option for patients.

Description

technical field [0001] The invention relates to the application of the composition, especially the application of the composition of Eucommia leaves and Kudingcha in the preparation of medicines for preventing and treating diabetes and its complications. Background technique [0002] Diabetes Mellitus (DM) is a common endocrine and metabolic disorder and frequently-occurring disease. Prolonged illness can cause multi-system damage, leading to eye, kidney, nerve, heart, blood vessel and other diseases. With the aging of the population, the economic development of various countries and the change of people's lifestyle, the prevalence of diabetes is increasing rapidly around the world, seriously threatening human health. Currently, there are 150 million DM patients worldwide, and it is predicted that the number will reach 300 million in 2025. In recent years, the prevalence of DM in my country has increased rapidly. In 2002, there were about 40 million DM patients, of which mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61P3/10A61P9/00A61P9/14A61P17/02A61P25/00
CPCA61K36/185A61K36/46A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P3/10A61P9/00A61P9/14A61P17/02A61P25/00A61K2300/00
Inventor 张芝庭何莉华张涛涛
Owner GUIZHOU MAQIKA PHARMA
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