Hollow fiber membrane, hollow fiber membrane type blood purifier

A technology of fiber membranes and purifiers, applied in the field of hollow fiber membranes and hollow fiber membrane blood purifiers, which can solve the problems that the performance of membrane components cannot be said to be sufficient

Inactive Publication Date: 2018-10-23
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the removal of DEHP depends on the adsorption on the surface of the membrane. Therefore, there is a possibility of reaching adsorption saturation with a small amount of adsorption. When considering the use in CRRT accompanied by long-term contact with blood, the performance of the above-mentioned membrane components cannot say enough

Method used

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  • Hollow fiber membrane, hollow fiber membrane type blood purifier
  • Hollow fiber membrane, hollow fiber membrane type blood purifier
  • Hollow fiber membrane, hollow fiber membrane type blood purifier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] The film spinning stock solution was prepared by dissolving 17 wt% of polysulfone (manufactured by Solvay, P-1700) and 4 wt% of polyvinylpyrrolidone (manufactured by BASF Corporation, K-90) in dimethylacetamide (Kishida Chemical Co., Ltd., Special Grade Reagent) 79 wt%. A 60 wt% aqueous solution of dimethylacetamide was used as the hollow inner liquid.

[0157] Make the film-making spinning dope and the hollow inner liquid spray out from the spinneret with the tubular shape in the orifice. The temperature of the film-forming spinning stock solution at the time of discharge was set to 40°C. The ejected spinning dope for film forming was immersed in a 60° C. coagulation bath containing water through a falling portion covered with a cover to be coagulated. At this time, the air gap length was 400 mm, and the spinning speed was 30 m / min. After coagulation, it is washed with water and dried to obtain a blood purification membrane. Here, the drying temperature was set to ...

Embodiment 2

[0163] The blood purifier of Example 2 was obtained in the same manner as in Example 1 except that the concentration of α-tocopherol (Wako Pure Chemical Industries special grade) in the coating solution was changed to 0.25 wt%.

Embodiment 3

[0165] The blood purifier of Example 3 was obtained in the same manner as in Example 1 except that the concentration of α-tocopherol (Wako Pure Chemical Industries special grade) in the coating liquid was changed to 2.0 wt%.

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Abstract

The invention relates to hollow fiber membrane, hollow fiber membrane type blood purifier. The present invention provides a hollow fiber membrane and a blood purifier which have the same anti-oxidation property as in the related art, and also have an effect of suppressing the oxidative stress from the dialysate side and an effect of adsorbing the plasticizer. A hollow fiber membrane which is a hollow fiber membrane comprising a fat-soluble antioxidant. The amount of the fat-soluble antioxidant in the unit effective membrane area of 1 m 2 is 50 mg / m 2 or more and 600 mg / m 2 or less. The cut surface of the hollow fiber membrane was removed from both ends by 5 [mu]m, and the remaining film thickness was halved. When the TOF-SIMS normalized peak intensities in each of the inner region, the intermediate region, and the outer region are Ii, Ic, and Io, respectively, Ii is 0.18 or more, and Ic / Ii is 0.80 or more and 1.0 or less, and Io / Ii is 0.70 or more and 1.0 or less.

Description

technical field [0001] The invention relates to a hollow fiber membrane and a hollow fiber membrane blood purifier. Background technique [0002] So far, blood purification methods using membrane separation techniques such as hemodialysis, hemofiltration, and hemofiltration dialysis have been examined. These blood purification therapies are widely applicable not only to patients with chronic renal insufficiency but also to patients with acute renal insufficiency, and in recent years, they have been widely practiced in life-saving and emergency care, ICU and the like. [0003] For patients with acute renal insufficiency, when complicated with multiple organ insufficiency, or circulatory dynamic instability, compared with patients with chronic renal insufficiency, most of them are serious morbid conditions. Therefore, when blood purification treatment using membrane separation is performed on patients with acute renal insufficiency, the circulation flow rate is lowered compar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D69/02B01D71/68A61M1/16A61M1/36
CPCA61M1/3621A61M2202/0413A61M1/1623B01D69/02B01D69/08B01D71/68B01D2325/36A61M2202/0021
Inventor 溝田萌佐佐木亮助川威
Owner ASAHI KASEI MEDICAL CO LTD
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