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Application of butyl p-hydroxybenzoate in preparing candida albicans resistant drugs

A technology of butyl hydroxybenzoate and Candida albicans, applied in the field of biomedicine, can solve problems such as drug resistance and seriousness, and achieve the effects of low toxicity and difficulty in producing drug resistance

Inactive Publication Date: 2018-11-06
SOUTH CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, there are limited types of antifungal drugs in clinical practice, among which azole drugs (fluconazole) are widely used, and fluconazole acts as a bacteriostasis by inhibiting fungal replication effect, but with the abuse of antibiotics, the phenomenon of drug resistance is becoming more and more serious

Method used

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  • Application of butyl p-hydroxybenzoate in preparing candida albicans resistant drugs
  • Application of butyl p-hydroxybenzoate in preparing candida albicans resistant drugs
  • Application of butyl p-hydroxybenzoate in preparing candida albicans resistant drugs

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Embodiment 1

[0022] Embodiment 1 butyl p-hydroxybenzoate antibacterial activity detection

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Abstract

The invention discloses an application of butyl p-hydroxybenzoate in preparing candida albicans resistant drugs. According to the application, the inventor takes candida albicans as the test object toscreen effective and low-toxicity chemical compound not easy to generate drug resistance, and finds that butyl p-hydroxybenzoate have good suppression effect to adhesion and pathogenicity of candidaalbicans. Besides, the chemical compound has low toxicity which cannot affect growth of human cells. Meanwhile, no influence is caused to normal growth of candida albicans, that is to say, the chemical compound suppresses adhesion, hypha formation, biofilm formation and pathogenicity of candida albicans rather than kills candida albicans mainly, and accordingly is not easy to generate drug resistance. The development of the novel antifungal drug, especially the development of the candida albicans resistant drugs has good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of butyl p-hydroxybenzoate in the preparation of anti-candida albicans drugs. Background technique [0002] Candida albicans (Candida albicans) is a fungal disease widely spread in humans. It is an important opportunistic pathogenic fungus, usually causing acute, subacute or chronic infections, and it is also one of the most important pathogens of hospital-acquired infections. . On healthy human mucosal surfaces, such as the oral cavity and intestinal tract, Candida albicans usually does not cause disease, but in patients with compromised or suppressed immune systems, such as chemotherapy patients, organ transplant patients or AIDS patients, it can cause serious systemic damage. Sexual infection, the fatality rate is as high as 40%. [0003] At present, there are limited types of antifungal drugs clinically, among which azole drugs (fluconazole) a...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61P31/10
CPCA61K31/235A61P31/10
Inventor 邓音乐宋施豪孙秀云李康陈俐
Owner SOUTH CHINA AGRI UNIV
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