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Nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion

A nano-emulsion and nasopharyngeal cancer technology, which is applied in the field of anti-nasopharyngeal cancer traditional Chinese medicine nano-emulsion, can solve the problems of poor treatment effect of nasopharyngeal cancer and can not be well matched with radiotherapy, so as to improve the stability and use efficacy, Guaranteed storage time and curative effect, maintaining stability

Active Publication Date: 2018-11-06
云南根之然生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicines in the prior art have poor therapeutic effects on nasopharyngeal carcinoma, and they cannot cooperate well with radiotherapy to produce a synergistic effect and improve the effective rate of nasopharyngeal carcinoma

Method used

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  • Nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion
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  • Nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion

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preparation example Construction

[0051] The preparation method of n-hexanoyl carboxymethyl chitosan is: dissolve 0.50 g of carboxymethyl chitosan in 10 g of water, stir for 12 hours until completely dissolved, add 10 mL of methanol and stir for 30 min, add 0.33 mL of n-hexanoic anhydride under rapid stirring Reaction 12h. After the reaction, the solution was dialyzed with 25% ethanol aqueous solution for 24h with a mass fraction, and then dialyzed with pure water for 24h, and the dialysate was vacuum freeze-dried to finally obtain n-hexanoyl carboxymethyl chitosan; the vacuum freeze-drying condition was controlled The thickness of the material is 8mm, the pre-freezing temperature is set at -22°C, when the sample temperature drops to -22°C, keep for 2h, the sublimation temperature is set at 15°C, the analysis temperature is 35°C, the absolute pressure is 35Pa, and dried for 24h; the dialysis The dialysis bags used had a molecular weight cut-off of 3500 Da.

[0052] Carboxymethyl chitosan: CAS: 83512-85-0, mol...

Embodiment 1

[0070] An anti-nasopharyngeal cancer traditional Chinese medicine nanoemulsion, comprising the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Gynostemma pentaphyllum, 6 parts of Dendrobium, 15 parts of iron-coated gold, 8 parts of Pteris vulgaris, 10 parts of Wulingzhi, 3 parts of dry lacquer, and 3 parts of cypress, 5 parts of mountain bean root, 7 parts of soil fritillary, 4 parts of centipede, 8 parts of magnolia, 14 parts of Ophiopogon japonicus, 9 parts of French pinellia, 11 parts of licorice, 9 parts of bletilla, 12 parts of Hedyotis diffusa .

[0071] The preparation method of described anti-nasopharyngeal cancer traditional Chinese medicine nanoemulsion comprises the following steps:

[0072] S1 crushing the raw materials of Chinese medicines to 40 meshes respectively, weighing the raw materials of Chinese medicines after being pulverized according to the proportion and mixing them uniformly to obtain coarse powder of Chinese medi...

Embodiment 2

[0081] An anti-nasopharyngeal cancer traditional Chinese medicine nanoemulsion, comprising the following traditional Chinese medicine raw materials in parts by weight: 10 parts of Gynostemma pentaphyllum, 6 parts of Dendrobium, 15 parts of iron-coated gold, 8 parts of Pteris vulgaris, 10 parts of Wulingzhi, 3 parts of dry lacquer, and 3 parts of cypress, 5 parts of mountain bean root, 7 parts of soil fritillary, 4 parts of centipede, 8 parts of magnolia, 14 parts of Ophiopogon japonicus, 9 parts of French pinellia, 11 parts of licorice, 9 parts of bletilla, 12 parts of Hedyotis diffusa .

[0082] The preparation method of described anti-nasopharyngeal cancer traditional Chinese medicine nanoemulsion comprises the following steps:

[0083] S1 crushing the raw materials of Chinese medicines to 40 meshes respectively, weighing the raw materials of Chinese medicines after being pulverized according to the proportion and mixing them uniformly to obtain coarse powder of Chinese medi...

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Abstract

The invention discloses nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion. The nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion is prepared from the following traditional Chinese medicine raw materials: fiveleaf gynostemma herb, herb dendrobii, radix berchemiae lineatae, herba pteridis multifidae, trogopterus dung, resina toxicodendri, herba selaginellaedoederleinii, radix sophorae tonkinensis, rhizoma bolbostemmae, scolopendra, flos magnoliae, radix ophiopogonis, rhizoma pinelliae praeparata, radix glycyrrhizae, bittersweet herb and herba hedyotidisdiffusae. The traditional Chinese medicine raw materials are subjected to superfine grinding by wet processing, and then extracted, thus extraction is more thorough, the active ingredients are more and safer, a chitosan derivative is taken as a carrier, and then the nanoemulsion is prepared and obtained. The nanoemulsion can go direct to the lesions and improves the curative effect. Compared withthe prior art, the nasopharynx cancer-resistant traditional Chinese medicine nanoemulsion can make up defects of operative treatment, radiotherapy and chemical treatment, not only can consolidate theeffects of radiation therapy and chemotherapy, but also can eliminate the toxic and side effects of chemoradiotherapy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a nanoemulsion of anti-nasopharyngeal cancer traditional Chinese medicines. Background technique [0002] Nasopharyngeal carcinoma is the most common malignant tumor of the head and neck that occurs in the nasopharynx. It has a high degree of malignancy and an insidious onset. It often has no obvious symptoms in the early stage, and cervical lymph node enlargement and systemic organ metastasis are common in the late stage. Its etiology includes genetic susceptibility, dietary environment and Epstein-Barr virus infection, etc. Its carcinogenesis process is relatively long, involving a variety of oncogenes, tumor suppressor genes and their interactions. [0003] The basic etiology mainly includes the following aspects: 1. Genetic factors: 1. The disease has racial heterosensitivity, and there are more people of yellow race than Caucasians, and the incidence of nasophary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/107A61P35/00A61K35/24A61K35/648
CPCA61K9/1075A61K35/24A61K35/648A61K36/11A61K36/12A61K36/22A61K36/42A61K36/424A61K36/484A61K36/489A61K36/575A61K36/72A61K36/748A61K36/81A61K36/8888A61K36/8968A61K36/8984A61K47/36A61P35/00A61K2300/00
Inventor 骆漫
Owner 云南根之然生物科技有限公司
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