171 results about "Nasopharynx carcinoma" patented technology

The invention provides a drug loading system of a tetrahedral structure. The structure of the drug loading system is Aptamer-AS1411-DNA. The structure of the drug loading system is Aptamer1-AS1411-DNA, and particularly the structure is formed by simultaneously connecting one Aptamer1 and three AS1411 onto a DNA tetrahedral body in an alkali complementary pairing way. The drug loading system is applied to a nasopharynx cancer drug, and is particularly applied to a drug targeting CD44<+> nasopharynx cancer cells; and meanwhile, the drug loading system is applied to a drug inhibiting the multiplication of nasopharynx cancer 5-8F cells.

The invention discloses an application of EB virus encoded microRNA BART10 (EBV-miR-BART10) in preparing a prediction preparation for recurrence and metastasis of nasopharyngeal carcinoma. The research proves that the expression level of EBV-miR-BART10 in the nasopharyngeal carcinoma tissue is in positive correlation with the lymphatic metastasis and the distant metastasis of the nasopharyngeal carcinoma patient; if the expression of the EBV-miR-BART10 in the nasopharyngeal carcinoma tissue is up-regulated, the nasopharyngeal carcinoma patient with higher EBV-miR-BART10 expression have larger possibilities of recurrence and metastasis than the nasopharyngeal carcinoma patient with lower EBV-miR-BART10 expression, and the prognosis is worse, therefore, the application of the expression of the EBV-miR-BART10 in the predication of recurrence and metastasis of the nasopharyngeal carcinoma patient can provide powerful biomolecular basis for the prognosis of the nasopharyngeal carcinoma patient, and thus the application method has profound clinical significances and important popularization and application prospects.

The invention relates to the field of biology, and discloses a double-gene co-expression recombinant plasmid pAdTrack-CMV-IL-24-polyA-promoter-OSM with the preservation number as China center for type culture connection number (CCTTCC NO.): M2011378, and a recombinant adenovirus Ad-IL-24-polyA-promoter-OSM prepared by the plasmid. An IL-24 gene and an OSM gene are subcloned between Ad-polyA-promoter empty carriers to construct the IL-24 and OSM double-gene co-expression recombinant plasmid, homologous recombination is performed between the recombinant plasmid and an adenovirus pAdEasy-1 to generate the recombinant adenovirus in packaging mode in a QBI-293A cell. The recombinant adenovirus has synergistic effect on inhibition of melanoma and cancer cells of nasopharyngeal darcinoma, and simultaneously has synergistic effect on radiosensitivity of the cancer cells of the nasopharyngeal darcinoma.

The invention discloses application of indeno triazine compounds as a substrate of quinone oxidoreductase depending on NAD (P) H. The indeno triazine compounds are catalyzed through the quinone oxidoreductase depending on the NAD (P) H to generate an oxidation reduction cycle reaction, a large number of reactive oxide free radicals are generated, strong oxidative stress is induced, and the obvious lethal effect on lung cancer, liver cancer, cervical cancer, pancreatic cancer, breast cancer, prostate cancer, nasopharynx cancer, kidney clear cell carcinoma, oral epidermoid carcinoma, chronic myelogenous leukemia, intestinal cancer, brain cancer, gastric cancer, esophagus cancer and other cancer cells expressed by the quinone oxidoreductase depending on the NAD (P) H is achieved. The indeno triazine compounds used as the substrate of the quinone oxidoreductase depending on the NAD (P) H can also be used as sensitizers for treating the cancer with radiotherapy, and have the obvious anticancer synergistic effect. In addition, the indeno triazine compounds used as the substrate of the quinone oxidoreductase depending on the NAD (P) H have antibacterial and antifungal activity.

The invention discloses a mouth opening training device for nasopharynx cancer. The mouth opening training device is composed of a trainer held in the mouth and a fixing device, wherein the trainer held in the mouth is fixedly arranged on the fixing device. When the mouth opening training device is used, a patient holds the trainer in the mouth, a fixing belt is fixed to the head of the patient, according to the conditions of the patient, a handle is rotated, a rotation rod rotates, a first tooth occluding block and a second tooth occluding block move vertically for controlling the mouth opening size of the patient, then the mouth opening training is carried out on the patient, after the mouth opening training of the patient is finished, the device is taken down, and a first silicon rubber case and a second silicon rubber case can be replaced, so that the operation is clean and sanitary. The mouth opening training device is simple in structure and convenient to operate, and is safe and comfortable, the replacement is convenient and sanitary during use each time, the patient is passively treated and complies with the treatment for a long term, the complications of the patient are effectively reduced, the mouth opening size can be finely adjusted, the mouth opening training device is applicable to patients in different disease conditions, the training purpose is achieved, the patients can carry out operation independently, the treatment effects are improved, the device has great significant for preventing the generation of mouth opening difficulty of the patients, and the cost is low.