Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Immune score for predicting nasopharyngeal carcinoma metastasis and application thereof

A nasopharyngeal carcinoma and risk prediction technology, applied in the field of biomedicine, can solve the problems of lack of verification, limited number of markers, small sample size, etc., and achieve accurate prediction and good clinical drug effect

Active Publication Date: 2020-03-20
SUN YAT SEN UNIV CANCER CENT
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previous studies on the tumor microenvironment of nasopharyngeal carcinoma had small sample sizes, lacked independent validation, and limited the number of major focus markers
In addition, co-expression of markers and characterization of non-malignant cells is often overlooked

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Immune score for predicting nasopharyngeal carcinoma metastasis and application thereof
  • Immune score for predicting nasopharyngeal carcinoma metastasis and application thereof
  • Immune score for predicting nasopharyngeal carcinoma metastasis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] In order to demonstrate the technical solutions, objectives and advantages of the present invention more concisely and clearly, the present invention will be further described in detail below in conjunction with experiments and accompanying drawings.

[0020] 1. Case screening:

[0021] The inventor selected 498 cases of nasopharyngeal carcinoma patient samples (training group, n=194; verification group, n=304) through radical radiotherapy for the initial treatment of non-metastatic nasopharyngeal carcinoma, wherein 37.6% (187 / 498) of the patients received Cisplatin-based concurrent therapy, 40.4% (201 / 498) patients received induction plus concurrent chemoradiotherapy. The median follow-up time was 62.0 months (quartile IQR 26.1-60.2), and 62 of 498 patients (12.4%) developed distant metastases during the follow-up period. Tissue microarrays were made from the paraffin tissue specimens of the newly diagnosed biopsies of these 498 patients. Each patient was guaranteed t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a group of markers for predicting the metastasis risk of nasopharyngeal carcinoma. The markers comprise PDL1, CD163, CXCR5 and CD117. The molecular label formed by expression ofthe four immune molecules can reflect the biological specificity of a nasopharyngeal carcinoma patient, can more accurately predict the metastasis risk and prognosis of the nasopharyngeal carcinoma patient and better guide clinical medication, and the prediction efficiency of the molecular label for non-distant survival is superior to that of traditional N stages.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a group of markers for predicting the metastasis risk of nasopharyngeal carcinoma and establishing an immune scoring model for predicting the metastasis of nasopharyngeal carcinoma by using the markers. Background technique [0002] Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in China, with the highest incidence in South China and Hong Kong, and the age-standardized incidence rate can reach more than 20 / 100,000. Nasopharyngeal carcinoma is most likely to occur in the prime of life between 40 and 50 years old, and it is likely to have a major impact on society, economy, labor force and family. With the advancement of radiotherapy technology, the local control rate of nasopharyngeal carcinoma has been significantly improved, and distant metastasis is the main reason for the failure of nasopharyngeal carcinoma treatment. [0003] Clinically, the distant meta...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N33/574G01N33/68G06Q10/06G16H50/30
CPCG01N33/57407G01N33/57484G01N33/68G06Q10/06393G16H50/30G01N2333/70532G01N2333/70596G01N2333/70503G01N2333/715G01N2800/50
Inventor 麦海强唐林泉刘赛兰焦磊
Owner SUN YAT SEN UNIV CANCER CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com