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Medicine composition for treating urgent and chronic myelocytic leukemiaia

A myeloid leukemia and composition technology, which is applied in the field of pharmaceutical compositions for the treatment of acute and chronic myeloid leukemia, and can solve the problems of strong antispasmodic effect

Inactive Publication Date: 2009-06-10
天津金世制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ② Antispasmodic effect Chinese kudzu root (species not specified) and Japanese kudzu root both contain astragalus flavonoids, which have papaverine-like antispasmodic effect on isolated intestines of mice and guinea pigs, but Chinese kudzu root is more antispasmodic than Japanese kudzu root The strong effect may be related to the large amount of flavonoids contained in it. This antispasmodic component can resist the effects of histamine and acetylcholine; other isoflavone derivatives isolated from Japanese kudzu root have no obvious effect on expanding acetylcholine

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 30 parts of kudzu root were heated or percolated twice, the two extracts were combined, the ethanol was recovered under reduced pressure, and the crude extract was obtained, and the dregs were discarded. The crude extract is adjusted to pH 7-8 with 5% NaOH solution to obtain an alkaline liquid, which is extracted with chloroform (or petroleum ether). Separate the solvent layer, discard it, adjust the pH of the water layer to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify the precipitate for later use. After drying, 30g (C) is obtained, and the solution is extracted with chloroform (or petroleum ether). The layers were separated, the water layer was concentrated to obtain 86g, and the solvent layer was concentrated to obtain an extract, which was dried to obtain 40g of (D), which was uniformly mixed with the acidic precipitate to obtain 70g of the mixture. Mix the extract with 10 parts of dehydrated dulcitol evenly, add 250 ml of 5% sodium chloride saline f...

Embodiment 2

[0025]15 parts of Pueraria root were extracted twice with 18 times the amount of 50% ethanol, the two extracts were combined, and the ethanol was recovered under reduced pressure to obtain a crude extract, and the dregs were discarded. Adjust the pH of the crude extract to 7-8 with 5% NaOH solution to obtain an alkaline liquid, filter, discard the precipitate, adjust the pH of the supernatant to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify Standby, after drying, 34g was obtained. The solution was extracted with ethyl acetate (or n-butanol), separated into layers, the water layer was discarded, and the solvent layer was concentrated to obtain the extract, which was dried to obtain 45g, and mixed with the acidic precipitate to obtain a mixture of 79g. The extract and 5 parts of dehydrodulcitol are uniformly mixed, 20 parts of starch and 5 parts of magnesium stearate are added, mixed and pressed into tablets.

Embodiment 3

[0027] 50 parts of kudzu root were extracted twice with 18 times the amount of 1% sodium hydroxide (or sodium carbonate) solution, the two extracts were combined, concentrated under reduced pressure to obtain a crude extract, and the dregs were discarded. The crude extract was applied to a silica gel column, eluted with chloroform (or ethyl acetate, methanol), and each fraction was collected for qualitative identification with magnesium powder-hydrochloric acid. The positive fractions were combined and concentrated under reduced pressure to obtain 30 g of the mixture. Mix the extract with 15 parts of dulcitol evenly, add No. 2 capsules, and make capsules.

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Abstract

The invention discloses a pharmaceutical composition for treating acute or chronic myeloblastic leukemia, which is characterized in that: it is made of dehydrated galactitol, kudzuvine root and pharmaceutical auxiliary materials. The composition in the invention has evident effect for treating leukemia, has an undoubted effect for treating lung cancer, multiple myeloma and nasopharyngeal carcinoma, especially has a preferable near term effect for treating chronic myeloblastic leukemia with a remission rate of 86%, has a higher effect for treating various lung cancer, and has lower poisonous and side effects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing dulcitol for treating acute and chronic myeloid leukemia Background technique [0002] Leukemia is a malignant disease of the hematopoietic system, characterized by extensive and uncontrolled proliferation of a large number of leukemia cells in the body, appearing in the bone marrow and many other organs and tissues, and entering the peripheral blood. Acute leukemia is characterized by rapid onset, rapid progress, and dangerous condition, which seriously endangers human health. With the advancement of medicine, most patients with acute leukemia can achieve remission after active treatment. Now remission of leukemia is no longer the ultimate goal of treatment. How to improve the cure rate so that most leukemia patients can be cured has become the focus of current hematology research . [0003] The medicinal use of kudzu root was first rec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P35/02A61K31/047
Inventor 宋富智
Owner 天津金世制药有限公司
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