Application of ulinastatin in preparations of anti-nasopharyngeal carcinoma metastasis medicines

A technology for ulinastatin and nasopharyngeal carcinoma, which is applied in the field of medicine to achieve the effects of strong inhibitory effect, inhibition of migration and invasion, and low toxicity

Active Publication Date: 2020-08-14
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for the metastasis of nasopharyngeal carcinoma, there is no clear ...

Method used

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  • Application of ulinastatin in preparations of anti-nasopharyngeal carcinoma metastasis medicines
  • Application of ulinastatin in preparations of anti-nasopharyngeal carcinoma metastasis medicines
  • Application of ulinastatin in preparations of anti-nasopharyngeal carcinoma metastasis medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, a kind of anti-nasopharyngeal carcinoma metastasis drug preparation

[0031] Take filtered sterilized ulinastatin 1000U and mannitol 10g, add it to an appropriate amount of water for injection to dissolve, adjust the pH to 6.8, add water for injection to 1000ml, add sodium chloride to adjust isotonicity, filter aseptically, and dispense Freeze-dried under aseptic conditions in 1000 vials to obtain the product.

Embodiment 2

[0032] Embodiment 2, a kind of anti-nasopharyngeal carcinoma metastasis drug preparation

[0033] Take ulinastatin 2000U, 7g of stachydrine hydrochloride, 2.8g of dextran, and 10g of mannitol after filtration sterilization and add them to an appropriate amount of water for injection to dissolve, adjust the pH to 7.1, add water for injection to 1000ml, add chlorine Sodium chloride is used to adjust isotonicity, filtered aseptically, divided into 1000 vials, and freeze-dried under sterile conditions to obtain the product.

Embodiment 3

[0034] Embodiment 3, a kind of anti-nasopharyngeal carcinoma metastasis drug preparation

[0035] Take ulinastatin 5000U, 17.5g of stachydrine hydrochloride, 7g of dextran, and 5g of mannitol after filter sterilization and add them to an appropriate amount of water for injection to dissolve, adjust the pH to 6.9, add water for injection to 1000ml, add chlorine Sodium chloride is used to adjust isotonicity, filtered aseptically, and divided into 1000 vials to obtain the product.

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PUM

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Abstract

The present invention belongs to the technical field of medicines and specifically relates to an application of ulinastatin in preparations of anti-nasopharyngeal carcinoma metastasis medicines. Through cell in-vitro tests, the ulinastatin is found to be capable of inhibiting metastasis of nasopharyngeal carcinoma cells, does not inhibit growth of the nasopharyngeal carcinoma cells, and is less toxic and more conducive to rehabilitation of patients with nasopharyngeal carcinoma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of ulinastatin in the preparation of nasopharyngeal carcinoma metastasis-resistant medicine. Background technique [0002] Ulinastatin (UTI) was isolated and purified from the fresh urine of healthy adult males. It is a glycoprotein composed of 143 amino acids and is a broad-spectrum protease inhibitor. Experimental studies have found that it has the function of inhibiting the activities of various enzymes such as plasmin, hyaluronidase, granulocyte elastase, α-chymotrypsin, and trypsin. Ulinastatin is mainly synthesized by the liver, metabolized by the kidneys, and then excreted in the urine. Its decomposed small molecular components also have a strong activity of inhibiting hydrolase. In addition to inhibiting trypsin, ulinastatin can also inhibit a variety of pancreatic enzyme activities, so it has a good therapeutic effect on acute pancreatitis ...

Claims

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Application Information

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IPC IPC(8): A61K38/57A61K9/08A61K9/19A61P35/04A61K31/40A61K31/721
CPCA61K9/0019A61K9/08A61K9/19A61K31/40A61K31/721A61K38/57A61P35/04A61K2300/00
Inventor 钱朝南李长志宋建东
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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