EBV capture probe and method for acquiring EBV genome sequence information in sample

A genome sequence and capture probe technology, applied in biochemical equipment and methods, recombinant DNA technology, microbial measurement/testing, etc., can solve the problems of low probe capture efficiency, low probe coverage, no special design, etc. , to achieve the effect of avoiding non-specific data, high capture efficiency and uniform coverage
CN107858451AInactive Publication Date: 2018-03-30SUN YAT SEN UNIV CANCER CENT
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV CANCER CENT
Publication Date
2018-03-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an EBV capture probe and a method for acquiring EBV genome sequence information in a sample. The capture probe designed by the invention has the following advantages: the capture efficiency on various EBV infection-associated diseases such as lymphoma, nasopharynx cancer and gastric cancer as well as EBV-containing cell lines (C666, Raji and snu179) is relatively high, the coverage degree is close to 100 percent and the sequencing data coverage is uniform, so that the chip can capture the information of the EVB genome well and has important significance in deep researchon the virus.
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Description

technical field

[0001] The invention relates to an EBV capture probe and a method for obtaining EBV genome sequence information in a sample. Background technique

[0002] Epstein-Barr virus (EBV), also known as human herpesvirus 4 (Human herpesvirus 4, HHV-4), commonly infects the global population. Studies have shown that EBV is closely related to nasopharyngeal carcinoma, lymphoma, gastric cancer and other tumors, mononucleosis and autoimmune diseases, suggesting that there may be specific pathogenic subtypes of EBV, and the specific mechanism has not yet been clarified. Therefore, the study of the EBV genome will help to reveal the pathogenic mechanism of EBV infection-induced diseases, and to screen out more effective clinical diagnosis and treatment-related virus molecular markers.

[0003] The current capture probe products designed for EBV have some common shortcomings: in various diseases related to EBV, such as lymphoma, nasopharyngeal carcinoma, gastric cancer, et...

Claims

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