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Ethanol extracting solution of desmodium renifolium and application thereof

A kind of kidney leaf leech alcohol and kidney leaf leech technology, applied in the field of kidney leaf leech alcohol extract, can solve the problems of exacerbating anemia indications and physical injuries of patients

Inactive Publication Date: 2018-11-27
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But from a health point of view, long-term dialysis will aggravate the signs of anemia of the patient and cause some damage to the body; and in terms of treatment costs, it is not acceptable to most patients, and due to their limited medical conditions, etc. For some reasons, not all patients can receive timely and effective treatment

Method used

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  • Ethanol extracting solution of desmodium renifolium and application thereof
  • Ethanol extracting solution of desmodium renifolium and application thereof
  • Ethanol extracting solution of desmodium renifolium and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A kind of alcohol extracting solution of leech locust, which is prepared according to the following steps:

[0046] Grinding the leech locust (whole herb) into a coarse powder, using 90-95% ethanol for continuous reflux extraction to obtain an ethanol extract.

[0047] Make a coarse powder, add 95% ethanol 8 times the volume of the medicinal materials for continuous reflux extraction, 5 times the amount for the second time, 3 times the amount for the third time, repeat 3 times in total, 45 minutes each time, combined extraction The solution was suction filtered while it was hot, and the final obtained total extract was placed on a rotary evaporator to concentrate and recover ethanol until the smell of ethanol could not be smelled, and the alcohol extract was obtained.

Embodiment 2

[0049] A kidney leaf leeches tablet, prepared by the following steps:

[0050] 1) After immersing the leech leech (whole herb) in normal water for 30 minutes, decoct twice, the decoction time of the two times is 1.5h and 1h respectively, let stand and filter respectively, and combine the filtrates of the two times;

[0051] 2) Concentrate the filtrate under reduced pressure into a clear paste with a relative density of about 1.2, place and cool to 40-50°C;

[0052] 3) Carry out alcohol precipitation treatment to clear ointment, make alcohol content reach 50%, stand still; After 48h, reclaim ethanol and continue to concentrate into the thick ointment that relative density is about 1.3, temperature is 40-50 ℃, vacuum drying, obtain dry paste;

[0053] 4) Grind the dry paste powder into 14 mesh particles with a swinging granulator or pulverizer, spray 70% ethanol to adjust the moisture content of the particles, add 0.5% magnesium stearate and 5% talcum powder and mix evenly with...

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Abstract

The invention relates to ethanol extracting solution of desmodium renifolium and an application thereof and belongs to the field of medicines. The ethanol extracting solution has the beneficial effects that the desmodium renifolium as a Dai medicine has an effect of preventing and treating chronic renal failure, and the mechanism is associated with improvement of renal anemia of a rat with chronicrenal failure and reduction of renal injury and renal interstitial fibrosis degree. The invention provides an application direction of the desmodium renifolium, the ethanol extracting solution and water extracting solution thereof in preventing and treating the chronic renal failure, provides a preparation method of desmodium renifolium tablets and provides pharmacodynamic basis for further research and development of the desmodium renifolium tablets.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to an alcohol extract of the licorice root and application thereof. Background technique [0002] CRF is a severe stage of chronic renal insufficiency, which has seriously threatened people's life and health. In the terminal stage (ie, the uremia stage), dialysis and kidney transplantation are effective treatments to maintain the patient's survival at this stage, and play an escort role in the terminal stage of treatment. But from a health point of view, long-term dialysis will aggravate the signs of anemia of the patient and cause some damage to the body; and in terms of treatment costs, it is not acceptable to most patients, and due to their limited medical conditions, etc. For some reasons, not all patients can receive timely and effective treatment. Therefore, finding suitable prevention and treatment drugs is the key to current clinical treatment. [0003] Dai medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/28A61P13/12
CPCA61K9/28A61K36/48A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61P13/12
Inventor 段小花冯德强王艳妮
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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