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Application of heparin iron in preparation of medicine for treating renal anemia

A technology of renal anemia and heparin, which is applied in the field of biomedicine to achieve the effect of increasing hemoglobin level and improving iron metabolism

Pending Publication Date: 2021-12-31
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Endothelial glycocalyx is shedding in patients with renal anemia, but there is no research report on the changes of erythrocyte glycocalyx in renal anemia

Method used

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  • Application of heparin iron in preparation of medicine for treating renal anemia
  • Application of heparin iron in preparation of medicine for treating renal anemia
  • Application of heparin iron in preparation of medicine for treating renal anemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Correlation between erythrocyte glycocalyx and erythrocyte lifespan in renal anemia mice

[0045] 1. Experimental method

[0046] 1.1 Establishment of renal anemia mouse model

[0047] Five-week-old C57BL / 6J male mice were balancedly fed for one week and randomly divided into two groups, model group and control group. The mice in the model group were fed with adenine every day at a dose of 50 mg / kg, and the mice in the control group were fed with 0.5% CMC-Na (10 mL / kg) every day for 28 days. At the same time, the mice in the model group were injected with turpentine (0.05 mL / 20 g) in the fat pads of the back scapula, and the mice in the normal group were given the same volume of normal saline, once every two weeks.

[0048] 1.2 Detection of mouse erythrocyte glycocalyx

[0049] Blood was collected from normal mice and renal anemia model mice by tail-cutting method, and plasma and red blood cells were obtained by centrifugation. Part of the normal mouse ery...

Embodiment 2

[0065] Example 2 Investigation of the effect of heparin iron targeting the glycocalyx-erythrocyte lifespan axis in improving renal anemia in mice

[0066] 1. Experimental method

[0067] 1.1 Preparation of heparin iron

[0068] With reference to Chinese patent CN201810128694.5, the specific steps are as follows: slowly add NaOH solution into FeCl3 solution, according to the molar ratio of Fe 3+ :OH - = After 1:2 mixing, adjust the pH to about 2.8 to form ferrous ions [Fe(OH) 2 ] + solution. According to the number of uronic acids in the heparin disaccharide structure, the number of sulfate groups and carboxylate groups contained in the heparin disaccharide structure, and [Fe(OH) 2 ] + Ion binding, prepared into heparin: [Fe(OH) 2 ] + = 1:2 complex solution, namely heparin iron. Slowly add the ferrous ion solution into the heparin sodium solution under ultrasonic conditions, and continue ultrasonication for half an hour after the addition is completed to prepare hepari...

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Abstract

The invention discloses application of heparin iron in preparation of a medicine for treating renal anemia. It is found that heparin iron can inhibit heparanase and matrix metalloproteinase 9 so as to relieve falling of glycocalyx and maintain the normal life of red blood cells, that is, the life axis of glycocalyx-red blood cells is targeted, and anemia is improved; meanwhile, heparin iron can improve the hemoglobin level, inhibit plasma hepcidin and improve iron metabolism.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of heparin iron in the preparation of medicine for treating renal anemia. Background technique [0002] Chronic kidney disease (chronic kidney disease, CKD) has become a major global public health problem due to its high incidence, strong concealment and low cure rate, which seriously threatens human health, especially in developing countries. my country is currently the country with the largest number of CKD patients in the world, with a total of 132 million patients. Anemia is a common complication of CKD. Anemia not only reduces the quality of life of CKD patients and increases medical costs, but is also closely related to the progression of CKD and the occurrence of cardiovascular events, leading to a corresponding increase in hospitalization and mortality. The pathogenesis of renal anemia is complex, and the common causes include EPO deficien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61K33/26A61P7/06A61P13/12
CPCA61K31/727A61K33/26A61P7/06A61P13/12
Inventor 崔慧斐李刘香
Owner SHANDONG UNIV
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