Micro blood detector and detection method for rapid detection of acute myocardial infarction markers

A technology for acute myocardial infarction and markers, which can be used in biological tests, instruments, measuring devices, etc., and can solve problems such as time-consuming and long-term

Active Publication Date: 2022-04-26
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the clinical detection of acute myocardial infarction markers needs to go through the steps of whole blood anticoagulation collection, serum extraction, etc., before they can be sent to the immune analyzer for biochemical testing, which takes a long time and requires professional operators to intervene and participate in the detection intermittently process

Method used

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  • Micro blood detector and detection method for rapid detection of acute myocardial infarction markers
  • Micro blood detector and detection method for rapid detection of acute myocardial infarction markers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A miniature blood detector for rapid detection of acute myocardial infarction markers, characterized in that it consists of a blood sampling port 1, a blood separator 2, a serum sampling port 3, an immunoadsorption reactor 4, and a pH sensitive field effect tube 5 and a micro-current detection circuit 6; the blood sampling port 1 is located on the top of the blood separator 2; the blood separator 2 is an airtight cylindrical tube inserted above the top cover of the immunoadsorption reactor 4, and the upper and lower ends are sealed by the upper end 7 and the lower end sealing plug 8 are sealed, and a blood separation membrane 9 is placed inside, and the bottom of the blood separator 2 is a serum outlet 3; a pH sensitive field effect tube 5 is placed at the bottom of the immunoabsorption reactor; the pH sensitive field effect tube 5 is composed of drain 10, source 11, gate 12 and pH sensitive film 13; the drain, source and gate of the field effect transistor 5 are respect...

Embodiment 2

[0029] The structure of the miniature blood detector for rapid detection of acute myocardial infarction markers in the present invention is the same as that in Example 1.

[0030] The blood separator 2 is an airtight cylindrical tube. The material is plastic. The bottom diameter is 1.5cm and the height is 4cm.

[0031] The blood separation membrane inside the blood separator is an ultra-thin nano-structure membrane layer prepared on a hollow fiber support body, and its material is alumina ceramics, and its structure is a hollow tubular structure. The outer diameter size is 2.5mm, the inner diameter is 0.7mm, the length is 5cm, and the pore diameter is 0.06μm.

[0032]The structure of the immunoadsorption reactor is a columnar reaction pool made of plastic, with a bottom diameter of 3 cm, an inner diameter of 2.5 cm, and a height of 2.5 cm.

[0033] The bottom of the immune adsorption reactor is equipped with a pH-sensitive field effect transistor 5. The gate material is InG...

Embodiment 3

[0037] A miniature blood detector (built-in type) for rapid detection of markers of acute myocardial infarction, characterized in that it consists of a blood sampling port 1, a blood separation membrane 9, an immunoadsorption reactor 4, a pH sensitive field effect tube 5 and The microcurrent detection circuit 6 is composed of; the blood sampling port 1 is located at the top of the immunoabsorption reactor 4 and is sealed by the upper sealing plug 7; the blood separation membrane 9 is an ultra-thin sheet membrane placed inside the immunoabsorption reactor 4, and its diameter The inner diameter of the immunoadsorption reactor is the same, the edge is sealed, and it is located below the top cover of the immunoadsorption reactor and above the liquid level; the bottom end of the immunoabsorption reactor 4 is equipped with a pH sensitive field effect tube 5; the pH sensitive field effect tube 5 is formed by a drain electrode 10 , source 11, grid 12, and pH sensitive film 13; the drai...

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Abstract

The invention relates to a micro-blood detector and a detection method for rapid detection of markers of acute myocardial infarction, comprising a blood sample inlet (1), a blood separator (2), a serum sample outlet (3), an immunoadsorption reaction composed of a device (4), a pH sensitive field effect tube (5) and a microcurrent detection circuit (6); the blood sample is injected from the sample inlet (1), flows through the blood separation membrane (9), and the serum enters the immunoadsorption reactor ( 4), the acute myocardial infarction marker antigen in the serum specifically binds to its antibody, and cross-links with the enzyme, resulting in a change in the pH value of the reaction solution, and then a change in the current signal of the pH-sensitive field effect tube (5), which is then detected by microcurrent The output of the circuit (6) shows the concentration of the tested marker. The present invention uses whole blood as a biological sample, combines membrane separation technology with miniature biological sensing elements, integrates blood separation membrane with miniature pH sensitive field effect tube, and measures The concentration of acute myocardial infarction markers can quickly and conveniently realize the clinical detection of acute myocardial infarction.

Description

technical field [0001] The invention belongs to the fields of medical inspection, biosensing principles and microelectronic technology, and relates to a micro-blood detector and a detection method for rapid detection of markers of acute myocardial infarction, aiming to design a fast and convenient A miniature blood detector for accurately detecting markers of acute myocardial infarction. Background technique [0002] Cardiovascular disease is a serious disease that endangers human health and life. Around the world, 17 million people die from cardiovascular disease every year. According to the statistics in the "China Cardiovascular Disease Report 2016", the current number of cardiovascular disease patients in my country is about 290 million, ranking first in the death rate of various diseases, accounting for more than 40% of the residents' disease deaths, and continues to rise. Acute myocardial infarction is a major cardiovascular disease, its onset is sudden, and the morta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/68G01N33/6887G01N2333/4712G01N2800/324
Inventor 金万勤王轶卿储震宇
Owner NANJING TECH UNIV
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