32 results about "Biochemical testing" patented technology

The present disclosure provides a biochemical test chip, including an insulating substrate, an electrode unit, a first insulating septum, a reactive layer and a second insulating septum. The electrode unit is located on the insulating substrate. The electrode unit includes a working electrode and a counter electrode. A current density of the counter electrode is greater than a current density of the working electrode. The first insulating septum is located on the electrode unit. The first insulating septum has an opening, which at least partially exposes the electrode unit. The reactive layer is located in the opening and is electrically connected to the electrode unit. The second insulating septum is located on the first insulating septum.

The utility model relates to the technical field of biochemical detection, in particular to a disposable convenient hemostix which comprises a blood sampling test tube, and a simple component is arranged on one side of the blood sampling test tube. The simple and convenient assembly comprises a sealing rubber cover, the sealing rubber cover is clamped to one end of the blood sampling test tube, the inner wall of the sealing rubber cover is fixedly connected with a first connecting tube and penetrates through one end of the blood sampling test tube, and the inner wall of the sealing rubber cover is fixedly connected with a second connecting tube and penetrates through one end of the blood sampling test tube. The other end of the first connecting pipe fixedly communicates with a liquid one-way valve. According to the utility model, through the disposable connecting strip and the connecting tube I in the simple and convenient assembly, the needle cylinder can be detached from the blood sampling test tube by manual tearing after the blood sampling is finished, and the needle tube and the test tube are integrally communicated in the blood sampling process, so that the condition that the blood is polluted can be prevented, and in the process, the assembly step before the blood sampling can be avoided; and the blood sampling time of the device is shortened.

Alzheimer's disease, the most common cause of dementia in older individuals, is a debilitating neurodegenerative disease for which there is currently no cure. In the past, AD could only be definitively diagnosed by brain biopsy or upon autopsy after a patient died. These methods, which demonstrate the presence of the characteristic plaque and tangle lesions in the brain, are still considered the gold standard for the pathological diagnoses of AD. However, in the clinical setting brain biopsy is rarely performed and diagnosis depends on a battery of neurological, psychometric and biochemical tests, including the measurement of biochemical markers such as the ApoE and tau proteins or the beta-amyloid peptide in cerebrospinal fluid and blood. The present invention discloses and describes panels of makers that are differentially expressed in the disease state relative to their expression in the normal state and, in particular, identifies and describes panels of makers associated with neurocognitive disorders. Such biomarker panel might have considerable value in triaging patients with early memory disorders to yet more specific but more invasive and costly approaches such as molecular markers in CSF and on PET imaging in clinical trials and possibly in clinical practice.

The invention discloses an actinomycete strain YC3041 and application of the actinomycete strain YC3041 in preparation of a biological preparation for preventing and treating tobacco phytophthora root rot. The actinomycete strain YC3041 is classified and named as Streptomyces pratensis; the strain is preserved in Guangdong Microbial Culture Collection Center (GDMCC), and the preservation address is the 5th floor, No. 59 building, No. 100 Courtyard, Xianlie Middle Road, Guangzhou; the preservation date is July 4, 2024; the preservation number of the strain is GDMCC No: 64828. Physiological and biochemical tests show that the YC3041 has the capabilities of gelatin liquefaction, milk dissolution and the like, can utilize various glycogens, and has the potassium dissolving capability. The YC3041 also has a certain inhibition effect on other pathogenic bacteria, such as YC1026 and YC1265. The invention provides a novel efficient biocontrol strain YC3041 for biological control of phytophthora root rot of tobacco, and the strain has a wide application prospect.

The invention relates to a general butt joint module for a production-free integrated assembly line, and relates to the field of medical instruments. Comprising a bottom plate, a portal frame, a test tube transfer manipulator assembly, a universal transfer trolley for butt joint of biochemical sample racks and a universal transfer trolley for butt joint of immune sample racks, a biochemical sample rack universal temporary storage position is arranged in the middle of the bottom plate; immune sample rack universal temporary storage positions are arranged on the two sides of the bottom plate; a track I and a track II are respectively arranged on two sides of the bottom plate, the universal transfer trolley for butting the biochemical sample frame is arranged on the track I in a sliding manner, and the universal transfer trolley for butting the immune sample frame is arranged on the track II in a sliding manner; the portal frame is mounted on the bottom plate, and the test tube transfer manipulator assembly is mounted on the portal frame and is used for accurately carrying samples needing biochemical detection in the immune sample frame into the biochemical sample frame. The device is exquisite in design, can effectively coordinate differences of biochemical and immune sample racks in the aspects of tracks and hole numbers, and realizes smooth connection and efficient transmission of the sample racks.

Described herein are interferometric sensors that can be used for biochemical testing. Each interferometric sensor includes an interference layer immobilized along a surface of a monolithic substrate. Analyte binding molecules can be coated along a surface of the interference layer. During biochemical testing, when analyte molecules in a sample bind to the analyte binding molecules, a biological layer will form. The monolithic substrate has a higher refractive index than the interference layer. Furthermore, the interference layer can be designed to have a refractive index that is substantially similar to a refractive index of the biological layer.

The application discloses a biochemical detection device and belongs to the technical field of rapid diagnosis. The biochemical detection device comprises a substrate and is provided with a liquid channel, a calibration channel and a gas channel on the substrate. The liquid channel comprises a liquid inlet channel and a reaction channel which are communicated with each other. The calibration channel is communicated with the reaction channel, and calibration reagent can flow into the reaction channel through the calibration channel. The gas channel is communicated with the liquid inlet channel, and gas can drive the liquid in the liquid inlet channel to flow to the reaction channel through the gas channel. A detection test paper is arranged on the reaction channel. The gas channel and the liquid channel are communicated with each other, so that the sample can conveniently flow from the liquid inlet channel to the reaction channel under the driving action of the gas. The sample flow is driven in a pneumatic mode, and the operation is simple and convenient. Meanwhile, the manufacturing process of the biochemical detection device is simplified, and the cost is reduced.

The present invention relates to an Os-Rh nanozyme, a preparation method thereof and an application thereof in detecting glyphosate. The present invention provides a novel Os-Rh nanozyme having peroxidase properties. The present invention also provides a method for preparing the Os-Rh nanozyme, which is obtained by reducing an aqueous solution of K2OsCl6, RhCl3·3H2O and glycine under ascorbic acid. The present invention also provides a dual-mode colorimetric platform based on the Os-Rh nanozyme to achieve high-sensitivity detection of glyphosate within a wide linear concentration range. The detection reagent or test paper for detecting glyphosate provided by the present invention can be used in the fields of chemical industry, environment, food and biochemical detection, and has high application value and good market prospects.

Introduced here is an approach to programmatically addressing the absorbance of light by analyte molecules whose binding, for example, to an interferometric sensor, is being monitored by an interferometric sensing system. A first light signal may be shone upon a biolayer over the course of a biochemical test, and the light reflected by the biolayer may form a second light signal that is detectable by a detector of an interferometric sensing system. Through analysis of the second light signal, the second light signal can be deconvolved into a reflection component and an absorbance component. If the principal component of the second light signal is the reflection component, then one algorithm may be employed to establish the binding magnitude. If the principal component of the second light signal is the absorbance component, then another algorithm may be employed to establish the binding magnitude.

The invention relates to the technical field of biochemical detection equipment, in particular to automatic sample treatment equipment and a use method thereof. The sample processing equipment comprises a consumable library; and the loading and unloading carrying mechanism is arranged on the working platform, is matched with the consumable library operation mechanism, and is used for receiving the new material rack sent by the consumable library or sending the old material rack back to the consumable library. A plurality of sample processing areas are sequentially arranged in the extension direction of a transfer slide rail of the loading and unloading carrying mechanism; and the executing mechanism is used for picking up the material rack at any position on the transferring slide rail and transferring the material rack to a sample processing area. The feeding and discharging carrying mechanism is matched with the consumable library to convey the material frame. And then the material rack is transferred to the positions, corresponding to different blood sample treatment areas, on the working platform through the transfer sliding rail, and the material rack is transferred to the corresponding blood sample treatment areas through the execution mechanism. According to the structural arrangement, each blood sample treatment area can work independently, and the working efficiency of the sample treatment equipment is effectively improved.

Biochemical Testing Device with Integrated Micro Pipettes

The present invention discloses a microfluidic chip, its preparation method, and application. The microfluidic chip includes a base layer; a detection layer disposed on the surface of the base layer and having a microfluidic channel disposed therein; and a sample feed strip disposed between the base layer and the detection layer, intersecting the microfluidic channel. The number of sample feed strips is at least one. The microfluidic chip of the present invention utilizes only one liquid drive control to perform biochemical testing on at least one sample, simplifying the microfluidic chip and reducing its liquid drive control requirements.

1. Name of the product in this design: suction head holder. 2. Purpose of this design: For use in biochemical testing instruments. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application provides a dry biochemical test card, a method and a test card system capable of identifying detection items, wherein a plurality of holes with different colors are arranged in the test card, the colors in the holes are corresponded to categories of the detection items, and threshold values of the colors in the holes are stored in an ID card; when the colors in the holes are identified, the corresponding categories of the detection items can be obtained; in order to prevent the ID card corresponding to the test card from being inconsistent, the identified color information in the holes is compared with the threshold values stored in the ID card to determine consistency. The application can reduce the complexity in identifying the detection items of the test card, improve the identification efficiency, prevent inconsistency and improve effectiveness.

This utility model discloses a motion module for a biochemical testing instrument, comprising: a mounting base, a mounting side plate fixedly mounted on one end of the mounting base, a lifting slide arm slidably mounted on one end of the inner side of the mounting side plate, and a telescopic slide block slidably mounted on one end of the inner side of the lifting slide arm; in this utility model, a stepper motor controls the rotation of a rotating lead screw, which drives the fixed lead screw sleeve screwed to it to slide up and down, thereby driving the lifting slide arm and the telescopic slide block to rise and fall. Simultaneously, during the upward and downward sliding of the fixed lead screw sleeve, the telescopic adjustment gear is connected to the fixed lead screw sleeve via a transition ring, thus controlling the rotation of the lead screw through the lead screw hole connected to the rotating lead screw while it is rising and falling. At this time, the internal rack meshing with the telescopic adjustment gear drives the telescopic slide block to synchronously slide horizontally within the lifting slide arm, thereby achieving more efficient synchronous lifting and telescopic positioning of the sample tube.

The present disclosure provides a reagent for biochemical testing that exhibits excellent long-term storage stability. The present disclosure also provides a method for suitably producing such a reagent for biochemical testing. The reagent according to the present disclosure includes heated catalase and is used in biochemical testing.

The present invention belongs to the field of medical detection and intelligent diagnosis and treatment technology, and specifically relates to a leg thrombosis detection and evaluation method, system and storage medium. The system integrates a main control device and a blood flow velocity detection device, a vascular ultrasound detection device, a hemodynamic detection device, a blood sample collection and analysis device, a risk level assessment device and a corresponding strategy generation device. Through the integration of the above devices, progressive risk level determination can be achieved. The thrombosis risk level is first determined through preliminary physical testing, and corresponding risk elimination strategies are formulated for different risk levels. Biochemical testing is performed on high-risk patients with third-level thrombosis risk, and the pathological pathogen and specific type of thrombosis are determined in combination with the patient's clinical symptoms and signs to generate a treatment plan. The thrombosis monitoring and judgment method process combines the advantages of physical methods and biochemical methods, which not only ensures the accuracy and scientific nature of the detection, but also reduces the patient's pain and medical burden.

Described herein is a method of programmatically addressing the absorption of light by an analyte molecule that is monitored by an interferometric sensing system, for example, in combination with an interferometric sensor. The first light signal may impinge on the biological layer during biochemical testing, and light reflected by the biological layer may form a second light signal detectable by a detector of the interferometric sensing system. By analyzing the second optical signal, the second optical signal can be deconvolved into a reflection component and an absorption component. If the principal component of the second optical signal is a reflected component, an algorithm may be employed to establish the bonding amplitude. If the principal component of the second optical signal is an absorption component, another algorithm may be employed to establish the binding amplitude.

The invention relates to the technical field of biomedicine, in particular to a blood biomarker for early coronary heart disease diagnosis and a screening method and application thereof. The blood biomarker comprises blood clinical indexes and plasma metabolome characteristics, the blood clinical indexes comprise direct bilirubin, aspartate aminotransferase and high-density lipoprotein, and the plasma metabolome characteristics comprise pyroglutamic acid, N-formyl-L-methionine, hypoxanthine, pinose and L-valyl-alanine. According to the method, blood clinical indexes are incorporated by using plasma metabolome characteristics and blood routine and blood biochemical detection, and compared with other methods, the physiological and pathological states of an organism are more comprehensively reflected, and the possibility of result deviation is reduced, so that the multi-dimensional blood biomarkers are adopted, and the detection accuracy is improved. And the early coronary heart disease risk can be predicted more accurately. In addition, by adopting the multi-dimensional blood biomarker, the specificity and sensitivity of screening and diagnosing the early coronary heart disease can be improved.

The present invention belongs to the technical field of biochemical testing, and specifically provides a streptavidin-coupled antibody capture CTC detection kit and a preparation method thereof, wherein the kit includes components such as biotin-modified EpCAM monoclonal antibody and Vimentin monoclonal antibody, a pretreatment agent, a separation liquid, a fixative, a permeabilization agent, a blocking agent, a fluorescent staining liquid and a microfluidic chip. The bottom layer of the chip channel is solidified with streptavidin, and the upper layer is an asymmetric herring bone structure, which can enhance the binding efficiency between cells and antibodies. The kit achieves efficient capture of CTCs of different phenotypes through multi-antibody composite recognition, and combines immunofluorescence staining for multi-marker detection, with both sensitivity and specificity. The method has a standardized process flow and stable components, and is suitable for the enrichment and analysis of CTCs in clinical samples.

A biochemical reaction device and a biochemical test system relate to the field of biochemical test technology, and include a first shell, a second shell and a clamping assembly. The first shell has a accommodating chamber, and a partition assembly is arranged in the accommodating chamber to divide the accommodating chamber into a first sub-chamber and a second sub-chamber. The first sub-chamber is used to store samples. The second shell is accommodated in the second sub-chamber. The second shell has a accommodating chamber, and the accommodating chamber is used to store reagents. A transport assembly is arranged on the second shell, one end of the transport assembly extends into the second shell and communicates with the accommodating chamber, and the other end of the transport assembly extends toward a direction close to the partition assembly; one end of the clamping assembly extends into the second sub-chamber and abuts against the second shell, and pressing the other end of the clamping assembly can push the second shell to move relative to the first shell, so as to drive the other end of the transport assembly to pass through the partition assembly and communicate with the first sub-chamber, so that the sample in the first sub-chamber enters the accommodating chamber through the transport assembly and reacts with the reagent in the accommodating chamber.

The invention discloses plant disease resistance inducing activity of a thyme extract and application of the thyme extract in preparation of a plant immune resistance inducer. The resistance inducer disclosed by the invention can activate systematic resistance of tobacco, and has a good prevention and control effect on various diseases. The thyme extract accounts for 10-50% of the plant resistance inducer in percentage by mass, and can be prepared into soluble liquid, soluble powder, water dispersible granules, emulsion in water, microemulsion and other preparation types. The bactericidal composition is used for preventing and controlling or relieving various plant fungi, bacteria and virus diseases such as tobacco mosaic virus diseases, strawberry gray mold, cucumber powdery mildew and the like on crops such as tobacco, strawberries and cucumbers. According to the present invention, the change of the thyme extract in vivo physiological indexes and disease resistance related genes caused by the thyme extract is determined by using biological activity determination, physiological and biochemical test and other methods, the plant disease resistance inducing activity of the thyme extract is determined, and the plant immune resistance inducer using the thyme extract as the active component is prepared and is used in the field.

Introduced here is an approach to programmatically addressing the absorbance of light by analyte molecules whose binding, for example, to an interferometric sensor, is being monitored by an interferometric sensing system. A first light signal may be shone upon a biolayer over the course of a biochemical test, and the light reflected by the biolayer may form a second light signal that is detectable by a detector of an interferometric sensing system. Through analysis of the second light signal, the second light signal can be deconvolved into a reflection component and an absorbance component. If the principal component of the second light signal is the reflection component, then one algorithm may be employed to establish the binding magnitude. If the principal component of the second light signal is the absorbance component, then another algorithm may be employed to establish the binding magnitude.

The present disclosure relates to a method, device, medium and equipment for predicting the amount of selenium addition using pig blood biochemical indicators, belonging to the field of data processing technology. The method comprises: extracting blood biomarker data related to the immune response mechanism by performing biochemical testing on collected pig blood samples; integrating the blood biomarker data, quantitative parameters of pig growth performance and dynamic ecological variables of the pig breeding environment into a multidimensional feature vector and inputting it into a selenium demand prediction model, obtaining the pig's physiological requirement for selenium output by the selenium demand prediction model, the selenium demand prediction model using the multidimensional feature vector of historical samples as input data and the corresponding reference selenium requirement as a supervision label, and being constructed through multi-layer neural network architecture training; calculating and adjusting the ratio of selenium addition in pig feed based on the pig's physiological requirement for selenium. In this way, the problem of excess or insufficient selenium caused by the traditional fixed addition method is avoided.

The invention discloses citral-amino-oligosaccharide Schiff base and application of the citral-amino-oligosaccharide Schiff base as a plant resistance inducer. The citral-amino-oligosaccharide Schiff base disclosed by the invention can activate systematic resistance of tobaccos, and has a good prevention and control effect on various diseases. According to the present invention, the plant disease resistance inducing activity, the plant stress resistance inducing activity and the plant growth promoting activity of the citral-amino-oligosaccharide Schiff base are determined by using biological activity determination, physiological and biochemical testing and other methods, and the pesticide preparation, the auxiliary agent and the biostimulant using the citral-amino-oligosaccharide Schiff base as the active component are prepared; the method is applied in fields.

The utility model discloses a sample separation and extraction device for biochemical inspection, and belongs to the technical field of separation and extraction. Comprising a separation body, a separation groove is formed in one side of the separation body, a taking device is arranged in the separation groove and comprises a partition plate and a motor, two sliding sleeves are embedded in the top of the partition plate, supporting rods are slidably connected to the inner walls of the two sliding sleeves, and the bottoms of the two supporting rods are connected with the same moving plate; a nut is embedded in the moving plate, the inner wall of the nut is in threaded connection with a threaded rod, and one end of the threaded rod is connected with an output shaft of the motor; according to the test tube taking device, the taking device is arranged, a motor drives a threaded rod to rotate, the threaded rod drives a movable plate to move upwards through a nut, then a supporting rod is driven to move upwards, the supporting rod drives a lifting plate to move upwards, the lifting plate drives a test tube to move upwards by a certain distance, and then personnel can take the test tube conveniently; therefore, the use convenience of the device is improved.

The invention relates to the field of biochemical detection, in particular to application of 3, 4-diaminobenzophenone in detection of alpha-keto acid and a detection method of the 3, 4-diaminobenzophenone. The invention discloses a reagent for detecting alpha-keto acid. The preparation method comprises the following steps: adding 2, 3, 4-diaminobenzophenone and a solvent; the detection method comprises the following steps: oscillating and uniformly mixing a to-be-detected sample and a reagent, then carrying out derivatization reaction, and after the derivatization reaction is finished, carrying out analysis by adopting matrix-assisted laser desorption / ionization time-of-flight mass spectrometry equipment, the reactive substrate 3, 4-diaminobenzophenone used in the invention can be subjected to a rapid derivatization reaction with alpha-keto acid under a heating condition, the problem of low ionization efficiency of alpha-keto acid is improved, other conventional substrates are not needed, and the sample pretreatment process is simplified; in addition, the reactive matrix shows good crystallinity on the MALDI target plate, and quantitative analysis of alpha-keto acid is facilitated.

Introduced here are rotors that can be placed inside of microplate wells that include liquid samples. Each rotor can be comprised of a ferromagnetic material. Accordingly, when a rotor is subjected to an external rotational magnetic field, the rotor spins and agitates the liquid sample inside the corresponding well. The spin speed may be adjusted by changing the rotation speed, direction, and / or orientation of the external rotational magnetic field. The rotor typically includes a central cavity within which a probe can be suspended during the biochemical test.

Introduced here is an approach to programmatically addressing the absorbance of light by analyte molecules whose binding, for example, to an interferometric sensor, is being monitored by an interferometric sensing system. A first light signal may be shone upon a biolayer over the course of a biochemical test, and the light reflected by the biolayer may form a second light signal that is detectable by a detector of an interferometric sensing system. Through analysis of the second light signal, the second light signal can be deconvolved into a reflection component and an absorbance component. If the principal component of the second light signal is the reflection component, then one algorithm may be employed to establish the binding magnitude. If the principal component of the second light signal is the absorbance component, then another algorithm may be employed to establish the binding magnitude.