Novel medical application of Nifuroxazide

A drug, psoriasis technology, applied in the field of new medical application of Nifuroxazide

Inactive Publication Date: 2018-12-21
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on the application of Nifuroxazide in the treatment of psoriasis. The present invention has found through research that Nifuroxazide has a significant inhibitory effect on the occurrence and development of psoriasis.

Method used

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  • Novel medical application of Nifuroxazide
  • Novel medical application of Nifuroxazide
  • Novel medical application of Nifuroxazide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] This example provides the effect of Nifuroxazide on the proliferation of skin keratinocytes HaCaT cells, and has a certain therapeutic effect on imiquimod-induced mouse psoriasis-like skin lesions. The mouse psoriasis-like model induced by imiquimod is a classic preparation method. The drug used, Nifuroxazide, was commercially available from Sigma (46494).

[0023] For the application of Nifuroxazide in the treatment of psoriasis described in this example, the effective dose range of Nifuroxazide is 2-10 μg / mL at the cellular level, the dosage for mice is 50-200 mg / kg, and the optimal dosage range is 4 μg at the cellular level / mL, the dosage for mice is 100mg / kg.

[0024] This example studies the effect of Nifuroxazide on the proliferation of skin keratinocytes HaCaT cells, and found that Nifuroxazide can significantly inhibit the proliferation of HaCaT cells and inhibit the phosphorylation of HaCaT cell stat3, the results are as follows Figure 1~2 shown.

[0025] ...

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Abstract

The invention discloses novel medical application of Nifuroxazide, namely the novel application of the Nifuroxazide as a medicine for treating psoriasis. The Nifuroxazide disclosed by the invention adopts peritoneal injection for treatment; the result shows that the Nifuroxazide can obviously relieve the formation of local scale of psoriasis sample skin lesion, erythema and incrassation induced byimiquimod, and inhibits the phosphorylation of stat3 in skin lesion tissues and the generation of TNF-alpha in serum. The Nifuroxazide is used to treat skin keratinocytes to form HaCaT cells; the result shows that the Nifuroxazide can significantly inhibit the proliferation of the HaCaT cells and inhibit the phosphorylation of HaCaT cell stat3. Therefore, the Nifuroxazide is used for treating thepsoriasis, and can be used for effectively inhibiting the proliferation of skin keratinocytes and relieving the inflammation degree of skin; in addition, a Nifuroxazide preparation has the advantagesof safety, no toxicity and convenience in use.

Description

technical field [0001] The invention belongs to the technical field of new medical applications, and in particular relates to the new medical applications of Nifuroxazide. Background technique [0002] Psoriasis is a common clinical chronic inflammatory skin disease, and its incidence accounts for 2%-3% of the world's population. At present, its pathogenesis has not been fully elucidated, but the excessive proliferation and abnormal differentiation of skin keratinocytes caused by various reasons and the infiltration of inflammatory cells in skin lesions are the direct reasons for the clinical manifestations and pathological changes of psoriasis patients. [0003] Signal transducers and activators of transcription 3 (STAT3) is an important nuclear transcription factor. Studies have found that it can strongly inhibit cell apoptosis, promote cell proliferation, and play a role in cell survival, transformation and migration. play an important role in the process. In recent yea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/345A61P17/06
CPCA61K31/345A61P17/06
Inventor 田中伟段亚菊田晨睿郭胜胡华付丹丹
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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