Novel mouse tail intravenous injection needle, manufacturing method thereof and experimental application

Abstract

The invention relates to the technical field of applications of experimental mice to in-vivo experiments, and particularly discloses a novel mouse tail intravenous injection needle, a manufacturing method thereof and an experimental application. The novel injection needle is used for mouse tail intravenous injection. On the basis of an existing medical 25G syringe needle, bilaterally symmetric side wings are added downwards from the midpoint of the needle to manufacture the novel needle. The novel needle is used for mouse tail intravenous injection, so that mouse tail intravenous injection success rate can be greatly increased. Compared with the traditional medical 25G syringe needle, the novel needle has the advantages that the novel needle is used for performing tail intravenous injection experiments on the mice, needle angles and needle lengths can be effectively controlled, and punching failure or piercing of tail veins caused by incorrect needle angles is maximally avoided.

Description

technical field [0001] The invention relates to the technical field of using experimental mice for in vivo experiments, in particular to a novel mouse tail vein injection needle and its manufacturing method and experimental application. Background technique [0002] Experimental mice are small in size, not aggressive, and easy to feed and operate. They are one of the most commonly used experimental animals for in vivo experiments. They are often used in experiments such as pharmacology, toxicology, tumors, immunity, and biochemistry. The experimental methods of mice mainly include intragastric administration, intraperitoneal injection, subcutaneous injection, tail vein injection, etc. Among them, tail vein injection is an important and commonly used experimental method. However, because the tail vein of the mouse is thin, it is difficult to puncture. During the injection process, the mouse twisted its body due to pain, causing the needle to slip out or puncture the tail vein...

AI Technical Summary

Problems solved by technology

Advantages of this method: there is no need to purchase a mouse fixation device, saving costs; Disadvantages: During the process of puncturing and pushing the needle, the mouse tends to twist its body, resulting in unstable needle fixation, which can easily slip out or puncture the tail vein

Advantages of this method: The body parts other than the tail of the mouse are relatively fixed, which reduces the range of its twisting body to a certain extent, which is beneficial to puncture and needle pushing; Disadvantage: Depending on the number of experimental mice, one or more commercial mice need to be purchased for fixation device, increasing the cost of experiments

[0004] The above two conventional mouse tail vein injection methods have both advantages and disadvantages, but the goal is to successfully complete the tail vein injection operation of each experimental mouse in order to obtain real and effective in vivo experimental data

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