Lactobacillus sialicus and application thereof in down-regulating gene expression of streptococcus mutans biofilm formation
A technology of Lactobacillus salivarius and Streptococcus mutans, applied in the field of microorganisms, can solve the problems of increased risk of drug resistance and low specificity of bactericidal effect
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[0031] Lactobacillus salivarius ZM06 is directly isolated from oral samples of healthy people. It is a Gram-positive bacillus that does not form spores and can grow in both aerobic and anaerobic environments.
[0032] Collect the thalli of logarithmic phase of MRS culture, adopt DNA extraction kit to extract DNA, carry out 16SrRNA gene sequencing, its sequence is shown in SEQ ID NO.31, this sequence is compared with GenBank database, can be identified as Lactobacillus salivarius ( Lactobacillus salivarius).
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