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Method for producing astragalus notoginseng mycoplasm by cordyceps-related fungi co-fermentation

A technology of co-fermentation of Cordyceps sinensis, which is applied in the field of co-fermentation and transformation of fungi related to Cordyceps sinensis to produce Astragalus notoginseng fungus, to achieve the effect of enhancing drug efficacy

Inactive Publication Date: 2019-01-18
GUIZHOU NORMAL UNIVERSITY
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Problems solved by technology

[0005] At present, there is no method on the market that uses traditional Chinese medicinal materials such as Astragalus membranaceus and Panax notoginseng as solid fermentation substrates, and co-cultures and ferments two fungi, Mortierella chinensis and Paecilomyces spp.

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  • Method for producing astragalus notoginseng mycoplasm by cordyceps-related fungi co-fermentation
  • Method for producing astragalus notoginseng mycoplasm by cordyceps-related fungi co-fermentation
  • Method for producing astragalus notoginseng mycoplasm by cordyceps-related fungi co-fermentation

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Embodiment Construction

[0010] In order to make the technical means, innovative features, goals and functions achieved by the present invention clearer and easier to understand, the present invention will be further elaborated below in conjunction with specific embodiments:

[0011] The present invention provides a kind of method for co-fermentation conversion of Cordyceps sinensis-related fungi to produce Astragalus notoginseng mycoplasm, the steps are as follows:

[0012] 1. Configure traditional Chinese medicine solid fermentation medium: oat 10-15g, astragalus 5-10g, panax notoginseng 5-10g, bee pupa powder 2-5g, soybean powder 6-10g, corn flour 3-5g and bran 2-6g, Mix the above raw materials with a pulverizer, pass through a 10-mesh sieve, put in a clean 1000mL beaker, add 60-75ml of water, sterilize in an autoclave at 121°C for 30min, take it out, let it stand, and cool to obtain solid fermentation of traditional Chinese medicine The culture medium is ready for use; the addition of traditional ...

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Abstract

The invention discloses a method for producing astragalus notoginseng mycoplasm by cordyceps-related fungi co-fermentation and application thereof. The technical scheme adopted includes: preparation of solid fermentation culture medium of traditional Chinese medicine, preparation of liquid culture medium, culture of liquid mother species, co-fermentation and transformation, drying of fermentationproducts, and ultrafine grinding. The bacterial substance cultured according to the technical scheme of the invention comprises astragalus membranaceus or notoginseng, All active constituents of Paecilomyces dauricus and Trichosporon chinensis, in a co-fermentation proces, Chinese medicinal herbs can activate the expression of silent secondary metabolic biosynthetic gene clusters of fungi, The invention simulates the formation process of natural Cordyceps sinensis, and converts radix astragali and radix notoginseng. Therefore, the bacterial quality cultured in the technical scheme of the invention is high in efficiency, stable, and the co-fermentation product has good immune enhancement effect, and the curative effect is good, which is far superior to the simple compatibility compound combination.

Description

technical field [0001] The invention relates to the field of microorganism cultivation and transformation, in particular to a method for co-fermenting and transforming fungi related to Cordyceps sinensis to produce Astragalus notoginseng mycoplasm. Background technique [0002] Cordyceps sinensis is a traditional valuable nourishing Chinese herbal medicine unique to my country, and its formation mechanism is complex. The microbial diversity of the surrounding environment of natural Cordyceps sinensis (membrane, surrounding soil) is very rich, forming a complex micro-ecosystem, in which Trichosporum sinensis is an anamorph of Cordyceps sinensis, and Paecilomyces batalis is an important associated fungus formed by natural Cordyceps sinensis. They play an important role in the quality formation of Cordyceps sinensis, and they compete with each other during the ripening process of Cordyceps sinensis, and have dynamic changes in different periods. Paecilomyces bat moth and Morti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068C12N1/14C12R1/79C12R1/645
CPCA61K36/068A61K2236/19C12N1/14
Inventor 张传博王艳丽杜静
Owner GUIZHOU NORMAL UNIVERSITY
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