A Chinese medicinal composition for invigorating kidney and promoting blood circulation, and its preparation method

A technology of invigorating the kidney and activating blood, traditional Chinese medicine, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antidote, etc., can solve the problems of insufficient extraction of resveratrol, low solubility of resveratrol, etc., to achieve optimal treatment The effect, the preparation method is simple, and the effect of the effective ingredient is improved

Active Publication Date: 2019-01-18
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of resveratrol in water is low, so decoction cannot fully extract the resveratrol in Chinese medicinal materials

Method used

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  • A Chinese medicinal composition for invigorating kidney and promoting blood circulation, and its preparation method
  • A Chinese medicinal composition for invigorating kidney and promoting blood circulation, and its preparation method
  • A Chinese medicinal composition for invigorating kidney and promoting blood circulation, and its preparation method

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Experimental program
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preparation example Construction

[0026] 3. Preparation of the standard curve of resveratrol in the extract: Accurately weigh an appropriate amount of the reference substance of resveratrol, add methanol to dissolve it, and make a stock solution of the reference substance with a mass concentration of 0.234 mg / ml, and dilute it equally to prepare A series of reference solution (concentrations of resveratrol are 0.234, 0.117, 0.058 5, 0.029 25, 0.014 63, 0.0073 125, 0.0036 563 mg / ml). Precisely measure 5 μl of each of the above-mentioned series of reference substance solutions, detect according to the above-mentioned HPLC method, obtain the peak area of ​​each concentration sample, and draw a standard curve. The regression equation is Y =3.92×10 7 X -55939.2 (r=0.9999, detection range: 36.56~234.00µg / ml).

[0027] 4. Preparation of reference substance (A) solution: resveratrol reference substance, the concentration is 0.234 mg / ml.

[0028] 5. Preparation of sample solution (B):

[0029] Take 10g of medlar, ...

Embodiment example

[0061] Case number one:

[0062] The traditional Chinese medicine preparation disclosed by the invention can be used for preventing and treating premature ovarian failure caused by the tripterygium wilfordii preparation.

[0063] In this study, 40 female patients with chronic nephritis were selected and randomly divided into a treatment group and a control group of 20 cases each. The treatment group was treated with tripterygium glycosides tablet 20 mg three times a day and the traditional Chinese medicine preparation disclosed by the present invention, and the control group was treated with tripterygium glycosides tablet 20 mg three times a day. If the menstrual cycle is shortened, the menstrual volume is reduced, or even amenorrhea occurs after 3 months, the tripterygium glycosides tablets should be stopped, and regular follow-up visits should be made to track the recovery of menstruation. The results show that the preparation of the present invention can effectively reduce...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation containing resveratrol and a preparation method thereof. Generally speaking, the traditional Chinese medicine preparation is decocted in water, which can not extract the effective ingredients from the medicinal materials effectively. However, the content of resveratrol inthe compound prescription is directly related to the curative effect, and the solubility of resveratrol in water is small for many prescriptions with remarkable curative effect in treating nephropathy and delaying senility. Therefore, the invention provides a prescription for tonifying kidney and promoting blood circulation, which is composed of the following traditional Chinese medicines in parts by weight: 5-15 parts of Lycium barbarum, 4-8 parts of rhizoma Polygoni Cuspidati, 5-15 parts of mulberry, 5-15 parts of Angelica sinensis, and 2-6 parts of Panax pseudo-ginseng. A Chinese medicinalextract is prepared by pretreating radix Et rhizoma Rhei, extract with ethanol, and making into extract. Bushen Huoxue Recipe has the effects of invigorating the spleen and kidney, promoting blood circulation, removing turbidity, anti-aging, and so on. Resveratrol can be extracted to the maximum extent by ethanol extraction, which can improve the effective ingredients of traditional Chinese medicine and optimize the therapeutic effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation containing resveratrol and a preparation method thereof. Background technique [0002] Resveratrol (Resveratrol, referred to as Res) is a non-flavonoid polyphenol compound, the chemical name is (E)-3,5,4-trihydroxystilbene, and the molecular formula is C 14 h 12 0 3 , with a relative molecular mass of 228.25g / mol, is a white needle-like crystal, exists in many plants, and is a phytoalexin produced when plants are subjected to biotic or abiotic stress (Song Hainan, Qian Shanjun, Liu Wei. Polygonum cuspidatum Research progress on extraction, analysis and detection technology of resveratrol [J] Guangzhou Chemical Industry, 2014, 42(21): 18-19.). High doses of resveratrol have anti-inflammatory, free radical scavenging, antibacterial and anti-cancer effects in the body. In our country, Chinese herbal medicine Polygonum cuspid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P13/12A61P39/06A61P15/08A61P29/00
CPCA61K36/232A61K36/258A61K36/605A61K36/704A61K36/815A61K2236/333A61K2236/53A61P13/12A61P15/08A61P29/00A61P39/06A61K2300/00
Inventor 祁爱蓉刘小燕刘宴娟李顺民李雨彦陈剑平
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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