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Two steroids and one triterpenoid and extraction method and application thereof

A technology of compounds and steroids, applied in the field of triterpenoids and their extraction, can solve the problem of incomplete research on the chemical components of Lagerstroemia indica

Active Publication Date: 2019-02-01
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its main active ingredients are triterpenes and steroidal components, but the existing research on the chemical components of Lagerstroemia indica is still not thorough enough, so the triterpenes and steroidal chemical components in Lagerstroemia indica still deserve further research and development use

Method used

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  • Two steroids and one triterpenoid and extraction method and application thereof
  • Two steroids and one triterpenoid and extraction method and application thereof
  • Two steroids and one triterpenoid and extraction method and application thereof

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Embodiment 1

[0090] 1. Extraction of steroidal compounds and triterpenoids

[0091] (1) Take 20 kg of dried Lagerstroemia grandiflora fruit, divide it into two equal batches for extraction, and extract each batch with 60 liters of 70% ethanol at 60°C for four times under reflux, combine all the extracts and concentrate under reduced pressure until the volume of the extract is 15 L ;

[0092] (2) extracting solution in step 1) is extracted successively with cyclohexane, chloroform, ethyl acetate and n-butanol of equal volume, obtains 109.5g chloroform layer;

[0093] (3) The chloroform layer (114.9g) was subjected to silica gel column chromatography, and eluted with chloroform-methanol gradient (100:1, 80:1, 50:1, 30:1, 20:1, 15:1, 10:1 , 5:1, 3:1, 1:1, 0:1; v / v), the sample A (26.7863g) of the 80:1 elution part was obtained;

[0094] (4) A was subjected to silica gel column chromatography, eluted with chloroform-acetone gradient (100:1~0:1:v / v), divided into 10 parts, and analyzed by rev...

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Abstract

The invention discloses two steroids and a triterpenoid and an extraction method and application thereof, and belongs to the field of medicine. The compounds are novel steroids and a triterpenoid, andare identified by physicochemical constants and modern spectroscopy. The physicochemical properties and chemical structure are clarified, thus providing powerful reference data for further research and development and utilization of triterpenoid and steroid chemical components in lagerstroemia speciosa. The separation and purification method of the invention is simple, efficient and mild; meanwhile, the pharmacodynamic test shows that the two novel steroids provided by the invention have better in-vitro anti-inflammatory activity and have anti-inflammatory activity against BV-2 cells, and itindicates that the compounds and tautomers and pharmaceutically acceptable salts thereof have great potential as a novel anti-inflammatory or Alzheimer's disease drug, which lays the foundation for further development of the anti-inflammatory or Alzheimer's disease drug.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to two kinds of steroidal compounds and one kind of triterpenoid compound and their extraction method and application. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to injury factors. Most diseases are accompanied by inflammation. Inflammation will aggravate the occurrence and development of diseases. Some chronic inflammations can lead to tumors. Therefore, the protection against inflammation Control and treatment are of great importance. Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. It is one of the main killers that threaten human health. At present, there is no effective cure. For the treatment of tumors, it has always been a Scientific research is constantly researching content. [0003] Natural medicines, especially those derived ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00C07J9/00C07J63/00A61P29/00A61P35/00A61P25/28A61K31/56A61K31/58A61K31/575A23L33/105
CPCA23V2002/00A23L33/105A61P25/28A61P29/00A61P35/00C07J9/00C07J63/008C07J71/001A23V2200/30A23V2200/308A23V2200/322A23V2250/21
Inventor 何祥久王宜海严飞黄雨颖
Owner GUANGDONG PHARMA UNIV
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