Two kinds of steroidal compounds and one kind of triterpenoids and their extraction method and application

A technology for compounds and steroids, applied in the field of triterpenoids and their extraction, can solve the problems such as insufficient research on chemical components of Lagerstroemia grandis, achieve good in vitro anti-inflammatory activity, simple separation and purification methods, and controllable quality Effect

Active Publication Date: 2021-05-25
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its main active ingredients are triterpenes and steroidal components, but the existing research on the chemical components of Lagerstroemia indica is still not thorough enough, so the triterpenes and steroidal chemical components in Lagerstroemia indica still deserve further research and development use

Method used

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  • Two kinds of steroidal compounds and one kind of triterpenoids and their extraction method and application
  • Two kinds of steroidal compounds and one kind of triterpenoids and their extraction method and application
  • Two kinds of steroidal compounds and one kind of triterpenoids and their extraction method and application

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Embodiment 1

[0090] 1. Extraction of steroidal compounds and triterpenoids

[0091] (1) Take 20 kg of dried Lagerstroemia grandiflora fruit, divide it into two equal batches for extraction, and extract each batch with 60 liters of 70% ethanol at 60°C for four times under reflux, combine all the extracts and concentrate under reduced pressure until the volume of the extract is 15 L ;

[0092] (2) extracting solution in step 1) is extracted successively with cyclohexane, chloroform, ethyl acetate and n-butanol of equal volume, obtains 109.5g chloroform layer;

[0093] (3) The chloroform layer (114.9g) was subjected to silica gel column chromatography, and eluted with chloroform-methanol gradient (100:1, 80:1, 50:1, 30:1, 20:1, 15:1, 10:1 , 5:1, 3:1, 1:1, 0:1; v / v), the sample A (26.7863g) of the 80:1 elution part was obtained;

[0094] (4) A was subjected to silica gel column chromatography, eluted with chloroform-acetone gradient (100:1~0:1:v / v), divided into 10 parts, and analyzed by rev...

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Abstract

The invention discloses two steroidal compounds and one triterpenoid compound, an extraction method and application thereof, and belongs to the field of medicine. The compound is a new type of steroidal compound and triterpenoid compound, and has been identified through physical and chemical constants and modern spectroscopy, and its physical and chemical properties and chemical structure have been clarified. The value of steroidal chemical composition provides powerful reference data; The separation and purification method of the present invention is simple, efficient, and gentle; Anti-inflammatory activity in vitro, has anti-inflammatory activity on BV‑2 cells, indicating that the compound, its tautomers, and pharmaceutically acceptable salts thereof have great potential as a novel anti-inflammatory or drug for the treatment of Alzheimer's disease , laying the foundation for the further development of anti-inflammatory or Alzheimer's disease drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to two kinds of steroidal compounds and one kind of triterpenoid compound and their extraction method and application. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to injury factors. Most diseases are accompanied by inflammation. Inflammation will aggravate the occurrence and development of diseases. Some chronic inflammations can lead to tumors. Therefore, the protection against inflammation Control and treatment are of great importance. Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. It is one of the main killers that threaten human health. At present, there is no effective cure. For the treatment of tumors, it has always been a Scientific research is constantly researching content. [0003] Natural medicines, especially those derived ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00C07J9/00C07J63/00A61P29/00A61P35/00A61P25/28A61K31/56A61K31/58A61K31/575A23L33/105
CPCA23V2002/00A23L33/105A61P25/28A61P29/00A61P35/00C07J9/00C07J63/008C07J71/001A23V2200/30A23V2200/308A23V2200/322A23V2250/21
Inventor 何祥久王宜海严飞黄雨颖
Owner GUANGDONG PHARMA UNIV
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