Method for detecting contents of carcinonitrile, quaternary ammonium salt and ammonium, potassium and calcium impurity ions thereof by adopting cation exchange suppressed conductance method

A technology of cation exchange and conductance suppression, applied in the field of analytical chemistry, can solve the problems of high detection limit, high cost, cumbersome operation, etc., and achieve low detection limit, good precision and good reproducibility

Active Publication Date: 2019-02-15
ZHEJIANG SHUREN UNIV
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Problems solved by technology

High-performance liquid chromatography-mass spectrometry uses expensive equipment and high cost; the titration end point of the titration method is difficult to observe and determine, and the detection limit is high and the operation is cumbersome; the spectrophotometric method is only applicable to a single quaternary ammonium salt or Total analysis of compound

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  • Method for detecting contents of carcinonitrile, quaternary ammonium salt and ammonium, potassium and calcium impurity ions thereof by adopting cation exchange suppressed conductance method
  • Method for detecting contents of carcinonitrile, quaternary ammonium salt and ammonium, potassium and calcium impurity ions thereof by adopting cation exchange suppressed conductance method
  • Method for detecting contents of carcinonitrile, quaternary ammonium salt and ammonium, potassium and calcium impurity ions thereof by adopting cation exchange suppressed conductance method

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[0026] The present invention will be further elaborated and illustrated below in conjunction with the accompanying drawings and specific embodiments. The technical features of the various implementations in the present invention can be combined accordingly on the premise that there is no conflict with each other.

[0027] 1. Instruments and reagents

[0028] Such as figure 1 As shown, it is a device for detecting the content of carnenitrile, quaternary ammonium salt and its impurities ammonium, potassium, and calcium ions by using the cation exchange suppression conductometric method. Including ion chromatography pump 6, six-way valve, sampling loop, IonPac CS 17 guard column 8, IonPacCS 17 analysis column 9, cation suppressor 10, conductivity detector 11 and workstation 12; ion chromatography pump 6 is connected with six-way valve, IonPac CS 17 guard column 8, IonPac CS 17 analysis column 9, cation suppressor 10 and conductivity detector 11; The sample injection loop is con...

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Abstract

The invention discloses a method for detecting the contents of carcinonitrile, quaternary ammonium salt and ammonium, potassium and calcium impurity ions thereof by adopting a cation exchange suppressed conductance method. The quaternary ammonium salt is N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride; the sample injection volume of a sample is 25[mu]L; after sample injection thereof, the sample is brought by an eluent into an IonPac CS 17 (4mm*50mm) guard column and an IonPac CS 17 (4mm*250mm) analytical column which are connected to an ion chromatograph for separation; 2mmol/Lof methanesulfonic acid is used as the eluent; at a flow rate of 1.0mL/min, conductance detection shows that the separation degrees of the carcinonitrile, 3-chloro-2-hydroxypropyltrimethylammonium chloride, NH4<+>, K<+> and Na<+> are greater than 1.5. By the method, the overall stability and the reproducibility are ideal and determination data are accurate and reliable; the method can be widely applied to food production, biomedicines and other industries.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a method for detecting carnenitrile, quaternary ammonium salts, and impurity ammonium, potassium, and calcium ion contents using a cation exchange-inhibited conductometric method, wherein the quaternary ammonium salt is N-(3-chloro- 2-Hydroxypropyl)-N,N,N-trimethylammonium chloride. Background technique [0002] (R)-3-cyano-2-hydroxy-N,N,N-trimethyl-1-propylammonium chloride, commonly known as carnenitrile, is mainly used in the production of L-carnitine and its derivatives, and L-carnitine Alkali is a kind of amino acid that promotes the conversion of fat into energy. It is widely found in various tissues of the human body. It is often added to infant milk powder and athlete's food, because it can transport fat to the mitochondria for burning. It can also be used as an important nutritional supplement for the human body. N-(3-chloro-2-hydroxypropyl)-N,N,N-trimet...

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Application Information

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IPC IPC(8): G01N30/96
CPCG01N30/96G01N2030/965
Inventor 叶明立陈梅兰林洋周晚晴
Owner ZHEJIANG SHUREN UNIV
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