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Injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel and preparation method thereof

A technology of magnetic water and self-controlling temperature, which can be used in liquid delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. It can solve the problems of temperature measurement and control of magnetic induction hyperthermia due to loss of nanoparticles, and low viscosity of delivery medium, and achieves the scope of application. The effect of wide range, improved targeting, and easy control of process quality

Active Publication Date: 2019-02-22
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems existing in the nanoparticle magnetic induction hyperthermia technology, the present invention proposes a self-temperature-controlling magnetic hydrogel based on room temperature injectable and body temperature curable. The temperature-controlled magnetic nanoparticles realize the locking of magnetic nanoparticles and the automatic control of the temperature of magnetic induction hyperthermia, which effectively solves the problem of loss of nanoparticles caused by the low viscosity and high fluidity of the transport medium and the difficulty of measuring and controlling the temperature of magnetic induction hyperthermia. problems, improving the targeting, safety and efficacy of hyperthermia

Method used

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  • Injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel and preparation method thereof
  • Injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel and preparation method thereof
  • Injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a) 5g Zn 0.54 co 0.46 Cr 0.6 Fe 1.4 o 4 Pour the self-temperature-controlling magnetic nanoparticles into 50 mL of deionized water, ultrasonically disperse them for 15 minutes, then add 286 μL of pure acetic acid solution, the concentration of self-temperature-controlling magnetic nanoparticles is 100 mg / mL, and the concentration of acetic acid is 0.1 mol / L .

[0023] b) Weighing 1.5 g of chitosan powder was added to the self-temperature-controlling magnetic nanoparticle acetic acid dispersion, and stirred with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the self-temperature-controlling magnetic nanoparticle dispersion A was obtained, and it was placed in a thermostat at 4° C. for 1 hour for later use. The concentration of chitosan in dispersion A was 30 mg / mL.

[0024] c) Weigh 2.4g of sodium glycerophosphate and 40mg of sodium hyaluronate powder, mix them evenly in a sample bottle, then add 4mL of de...

Embodiment 2

[0028] a) 7.2g Zn 0.54 co 0.46 Cr 0.6 Fe 1.4 o 4 Pour the self-temperature-controlling magnetic nanoparticles into 50 mL of deionized water, ultrasonically disperse them for 15 minutes, then add 286 μL of pure acetic acid solution, the concentration of self-temperature-controlling magnetic nanoparticles is 144 mg / mL, and the concentration of acetic acid is 0.1 mol / L .

[0029] b) Weigh 1 g of chitosan powder and add it to the self-temperature-controlling magnetic nanoparticle acetic acid dispersion, and stir with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the self-temperature-controlling magnetic nanoparticle dispersion A was obtained, which was put into a constant temperature box at 4° C. and left to stand for 2 hours for use. The concentration of chitosan in dispersion A was 20 mg / mL.

[0030] c) Weigh 600 mg of sodium glycerophosphate and 30 mg of sodium hyaluronate powder, mix them evenly in a sample bot...

Embodiment 3

[0034] a) 14.4g Zn 0.54 co 0.46 Cr 0.6 Fe 1.4 o 4 Pour the self-temperature-controlling magnetic nanoparticles into 100mL of deionized water, ultrasonically disperse them for 15 minutes, then add 286μL of pure acetic acid solution, the concentration of self-temperature-controlling magnetic nanoparticles is 144mg / mL, and the concentration of acetic acid is 0.05mol / L .

[0035] b) Weigh 500 mg of chitosan powder and add it into the acetic acid dispersion of self-temperature-controlling magnetic nanoparticles, and stir with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the self-temperature-controlling magnetic nanoparticle dispersion A was obtained, and it was placed in a thermostat at 4° C. and left to stand for 1.5 hours for use. The concentration of chitosan in dispersion A was 5 mg / mL.

[0036] c) Weigh 600 mg of sodium glycerophosphate and 80 mg of sodium hyaluronate powder, mix them evenly in a sample bottle...

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Abstract

The invention discloses an injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel and a preparation method thereof and belongs to the technical field of biomedicalmaterials. The injectable body-temperature-cured temperature-self-control thermotherapy magnetic hydrogel is prepared by taking an injectable body-temperature-cured hydrogel as a matrix and carrying magnetic nanoparticles, the hydrogel has the characteristics of room-temperature liquid injectability and body-temperature gel formation and curing, can be stabilized between the appointed thermotherapy temperatures (40-45 DEG C) and cannot be liquefied again even if being further heated after gel formation and curing. The preparation method comprises the steps: adding chitosan powder into a temperature-self-control magnetic nanoparticle dispersion solution to obtain a dispersion solution A; adding sodium glycerophosphate and sodium hyaluronate powder into deionized water obtain a mixed solution B; and dropwise adding the mixed solution B into the dispersion solution A in an ice bath state to obtain a product. The preparation process is simple, and the process quality is easy to control; and the obtained product is capable of avoiding the problem that the magnetic nanoparticles are easy to diffuse and lose after being injected into a human body, and the product is capable of heating under the action of an alternating magnetic field to reach the temperature required by thermotherapy so as to be wide in application range.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a self-controlling thermotherapy magnetic hydrogel injectable at room temperature and solidified at body temperature and a preparation method thereof. Background technique [0002] Because the temperature tolerance of normal cells is higher than that of tumor cells, by heating tumor tissue to an appropriate temperature (42-45°C), it can effectively kill cancer cells and effectively control the damage to surrounding normal cells, so hyperthermia is considered It is a greener and safer tumor treatment method than chemotherapy and radiotherapy. Among the hyperthermia methods, the magnetic hyperthermia method utilizes the characteristics of magnetic substances to heat up and generate heat in an alternating magnetic field. By implanting or intervening a magnetic medium into the target area of ​​the treatment, it uses magnetic induction to generate heat to selectively kill c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K41/00A61K47/24A61K47/36
CPCA61K9/0024A61K9/06A61K41/0052A61K47/24A61K47/36
Inventor 张伟丁帅文吴承伟
Owner DALIAN UNIV OF TECH
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