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An injectable body temperature curing thermotherapy magnetic hydrogel and its preparation method

A magnetic water and hydrogel technology, which is applied in the fields of pharmaceutical formulations, liquid transportation, wave energy or particle radiation treatment materials, etc., can solve the problems of difficult to achieve precise targeted therapy and limit clinical application, and achieve a wide range of applications and technological advantages. The effect of easy quality control and simple preparation process

Active Publication Date: 2021-01-19
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The high fluidity of nanoparticle ferrofluid makes it difficult for this hyperthermia method to achieve precise targeted therapy, which greatly limits its clinical application.

Method used

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  • An injectable body temperature curing thermotherapy magnetic hydrogel and its preparation method
  • An injectable body temperature curing thermotherapy magnetic hydrogel and its preparation method
  • An injectable body temperature curing thermotherapy magnetic hydrogel and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a) Pour 5g of ferroferric oxide magnetic nanoparticles into 50mL of deionized water, ultrasonically disperse it for 15 minutes, then add 286μL of pure acetic acid solution, the concentration of magnetic nanoparticles is 100mg / mL, and the concentration of acetic acid is 0.1mol / L.

[0023] b) Weighing 1.5 g of chitosan powder was added to the magnetic nanoparticle acetic acid dispersion, and stirred with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the magnetic nanoparticle dispersion A was obtained, and it was placed in a thermostat at 4° C. for 1 hour for later use. The concentration of chitosan in dispersion A was 30 mg / mL.

[0024]c) Weigh 2.4g of sodium glycerophosphate and 40mg of sodium hyaluronate powder, mix them evenly in a sample bottle, then add 4mL of deionized water, and stir with a magnetic stirrer until completely dissolved to obtain a mixed solution B, which is placed at 4°C Stand in an incu...

Embodiment 2

[0028] a) Pour 7.2g of ferroferric oxide magnetic nanoparticles into 50mL of deionized water, ultrasonically disperse it for 15 minutes, then add 286μL of pure acetic acid solution, the concentration of magnetic nanoparticles is 144mg / mL, and the concentration of acetic acid is 0.1mol / L.

[0029] b) Weighing 1 g of chitosan powder was added to the magnetic nanoparticle acetic acid dispersion, and stirred with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the magnetic nanoparticle dispersion A was obtained, and it was placed in a thermostat at 4° C. for 2 hours for later use. The concentration of chitosan in dispersion A was 20 mg / mL.

[0030] c) Weigh 600 mg of sodium glycerophosphate and 30 mg of sodium hyaluronate powder, mix them evenly in a sample bottle, then add 4 mL of deionized water, and stir with a magnetic stirrer until completely dissolved to obtain a mixed solution B, which is placed in a 4°C Stand in ...

Embodiment 3

[0034] a) Pour 14.4g of ferroferric oxide magnetic nanoparticles into 100mL of deionized water, ultrasonically disperse it for 15 minutes, then add 286μL of pure acetic acid solution, the concentration of magnetic nanoparticles is 144mg / mL, and the concentration of acetic acid is 0.05mol / L.

[0035] b) Weigh 500 mg of chitosan powder and add it into the magnetic nanoparticle acetic acid dispersion, and stir with a magnetic stirrer to accelerate the dissolution of chitosan. After the chitosan was completely dissolved, the magnetic nanoparticle dispersion A was obtained, and it was placed in a thermostat at 4°C for 1.5 hours for later use. The concentration of chitosan in dispersion A was 5 mg / mL.

[0036] c) Weigh 600 mg of sodium glycerophosphate and 80 mg of sodium hyaluronate powder, mix them evenly in a sample bottle, then add 4 mL of deionized water, and stir with a magnetic stirrer until completely dissolved to obtain a mixed solution B, which is placed in a 4°C Stand i...

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Abstract

The invention relates to an injectable body temperature cured thermal therapy magnetic hydrogel and a preparation method thereof and belongs to the technical field of biomedical materials. The hydrogel is prepared from an injectable body temperature cured hydrogel as a matrix carrying magnetic nano particles. The hydrogel has the characteristics of room temperature liquid injectability and body temperature gel curing, and can be stabilized at an appointed thermal therapy temperature (42-70 DEG C); and the hydrogel is not liquefied again in the thermal therapy heating process after gel formation. The preparation method comprises the following steps: firstly, adding a chitosan powder into a magnetic nano particle acetic acid dispersion liquid to obtain a dispersion liquid A; then, adding sodium glycerophosphate and sodium hyaluronate powder into deionized water to obtain a mixed solution B; and finally, dropwise adding the mixed solution B into the dispersion liquid A in an ice bath state to obtain a product. The preparation process is simple and easy to control quality. The obtained product can solve the problem that the magnetic nano particles injected to a human body are easy to diffuse and lose, can be heated under the action of an alternating magnetic field to achieve the thermal therapy needed temperature, and has a wide application range.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a thermotherapy magnetic hydrogel injectable at room temperature and solidified at body temperature and a preparation method thereof. Background technique [0002] Hyperthermia is a greener and safer tumor treatment method than chemotherapy and radiotherapy. In the hyperthermia method, the magnetic hyperthermia method uses the characteristics of magnetic materials to heat up and generate heat in an alternating magnetic field, and selectively kills cancer cells by implanting or intervening in the treatment target area without affecting normal tissues. , can achieve targeted therapy. Compared with ultrasonic thermotherapy, magnetic hyperthermia is not affected by air cavity, bone reflection, and bone resorption. Compared with microwave hyperthermia, it can heat deep areas in the body. Compared with radio frequency hyperthermia with electric field divergence, it can Pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K41/00A61K47/24A61K47/36A61P35/00
CPCA61K9/0009A61K9/0019A61K9/06A61K41/0052A61K47/24A61K47/36A61P35/00
Inventor 张伟丁帅文吴承伟马建立
Owner DALIAN UNIV OF TECH
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