The invention discloses an inflammation-diminishing Zhuang medicine preparation which is prepared from the following components in parts by weight: 10-50 parts of smilax scobinicaulis, 10-40 parts of cyclea hypoglauca, 10-40 parts of dichondra repens, 5-30 parts of abrus mollis and 5-30 parts of camellia chrysantha. The inflammation-diminishing Zhuang medicine preparation inherits the Zhuang medicine theory of toxic deficiency pathopoiesia and the treatment principle of regulating qi, removing toxin and tonifying deficiency, and with the combination of the traditional Chinese medicine theories and modern medicine techniques, Zhuang medicines such as smilax scobinicaulis, cyclea hypoglauca, dichondra repens, abrus mollis and camellia chrysantha are finely selected and matched to prepare the preparation, and the preparation has remarkable effects of clearing heat, removing toxin, removing swelling, relieving pain, removing stone, relieving spasm, stopping bleeding and diarrhea, converging wound, generating muscle, and the like, can be used for treating gynecologic inflammation, urinary tract infection, odynuria, hematuria, nephritis, enteritis, hepatitis, trachitis and the like, and is free of adverse reaction or toxic or side effect, controllable in process quality, easy to carry over and take and relatively wide in applicable people. The inflammation-diminishing Zhuang medicine preparation has great significance for prevention and treatment on global epidemic diseases.