Temperature control device of liposome extrusion device and application of temperature control device

A technology for a temperature control device and an extruder, which is applied in the field of temperature control devices for liposome extruders, can solve problems such as inconvenient temperature control, and achieve the effects of reducing the temperature fluctuation range, being beneficial to stability, and preventing high temperature

Pending Publication Date: 2019-02-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a liposome extruder temperature control device for solving the problem of inconvenient temperature control of the liposome extruder in the prior art

Method used

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  • Temperature control device of liposome extrusion device and application of temperature control device
  • Temperature control device of liposome extrusion device and application of temperature control device
  • Temperature control device of liposome extrusion device and application of temperature control device

Examples

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Embodiment 1

[0046] Example 1 as Figure 1~3 As shown, the present invention provides a liposome extruder temperature control device, the temperature control device at least includes an upper box body 1 and a lower box body 2, and the upper box body 1 and the lower box body 2 are all hollow case. In this embodiment, both the upper box body 1 and the lower box body 2 are regular hexahedrons. The bottom surface of the upper box body and the top surface of the lower box body form a cavity suitable for accommodating a liposome extruder with syringes installed at both ends after fastening.

[0047] Generally, the bottom surface of the upper box body 1 is a plane, the top surface of the lower box body 2 is a plane, and the bottom surface of the upper box body and the top surface of the lower box body are respectively provided with an upper groove 103 and a lower groove. Groove 203, the cavity surrounded by the upper groove 103 and the lower groove 203 is elongated and the two ends form the out...

Embodiment 2

[0057] Example 2 A certain amount of HSPC lipid was weighed, sucked into a micro-syringe, and a polycarbonate membrane with a pore size of 100 nm was loaded into a micro-extruder. The same preparation operation was performed with the traditional electric heating plate plus heat conduction block and the device in Example 1, and the temperature of the constant temperature water bath was set at 59°C. The result is as Figure 4 , it can be seen that both can successfully complete the membrane-passing operation, and their effect on particle size control is basically the same.

[0058] Figure 5 It shows that the surface temperature of the electric heating plate fluctuates between 50°C and 85°C, and the high temperature area is likely to cause burns to the operator. The heat on the electric heating plate is transferred to the heat conduction block, and the syringe is heated by the heat conduction block.

[0059] From Figure 6 It can be seen that the temperature of the heat cond...

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Abstract

The invention provides a temperature control device of a liposome extrusion device and application of the temperature control device. The temperature control device at least comprises an upper box body and a lower box body. The upper box body and the lower box body are both hollow shells. A groove formed after the bottom face of the upper box body and the top face of the lower box body are buckledis suitable for containing the liposome extrusion device, with injectors installed at the two ends, in a matched manner. The upper box body is provided with an upper water inlet and an upper water outlet. The lower box body is provided with a lower water inlet and a lower water outlet. The upper box body and the lower box body are each made of a heat conduction material. Due to the adoption of the device, the temperature of the liposome extrusion device can be effectively controlled during extrusion.

Description

technical field [0001] The invention relates to a liposome extruder temperature control device and application thereof. Background technique [0002] Liposomes are hollow vesicle assemblies made of lipids, which have a bilayer structure and can encapsulate drugs inside. The drug efficacy and toxicity of liposome are affected by many factors, and its particle size is one of its important parameters. The liposome can be prepared by extrusion method: the preparation raw material is passed through an extrusion device, and then passed through a polycarbonate membrane with a certain pore size to obtain a small and uniform liposome. Temperature has a great influence on the extrusion process. When the temperature is lower than the phase transition temperature of the preparation material, liposomes are difficult to extrude, so the extrusion process needs to control the temperature of the extruder above the phase transition temperature. [0003] At present, the temperature control d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29B9/06B29C48/92
CPCB29B9/06
Inventor 陈剑李君妍孙宝玲
Owner SHANGHAI JIAO TONG UNIV
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